HSPG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007224Biological processsmoothened signaling pathway
GO_0006954Biological processinflammatory response
GO_0006898Biological processreceptor-mediated endocytosis
GO_0007162Biological processnegative regulation of cell adhesion
GO_0031100Biological processanimal organ regeneration
GO_0072359Biological processcirculatory system development
GO_0016525Biological processnegative regulation of angiogenesis
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030154Biological processcell differentiation
GO_0001666Biological processresponse to hypoxia
GO_0007420Biological processbrain development
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0006629Biological processlipid metabolic process
GO_0007566Biological processembryo implantation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005925Cellular componentfocal adhesion
GO_0098797Cellular componentplasma membrane protein complex
GO_0005604Cellular componentbasement membrane
GO_0043202Cellular componentlysosomal lumen
GO_0001540Molecular functionamyloid-beta binding
GO_0070052Molecular functioncollagen V binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0030021Molecular functionextracellular matrix structural constituent conferring compression resistance
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHSPG2
Protein nameBasement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]
Heparan sulfate proteoglycan 2
Perlecan proteoglycan 2
HSPG2 protein
Heparan sulfate proteoglycan
Synonyms
DescriptionFUNCTION: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity.

AccessionsA0A0U1RQT3
ENST00000427897.1
H0Y5A9
ENST00000644714.1
ENST00000635682.1
B6EU51
A0A3B3IT11
H7BYA5
O43834
ENST00000374676.4
A0A2R8YH07
P98160
ENST00000374673.4
ENST00000374695.8
Q2VPA1