LTA | OmnibusX

Name	Number of supported studies	Average coverage
regulatory T cell	9 studies	32% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	5 studies	32% ± 27%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LTA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	94%	41.57	545 / 578	64%	1.91	742 / 1155
breast	67%	14.03	307 / 459	56%	2.06	627 / 1118
ovary	74%	22.09	134 / 180	46%	1.03	197 / 430
intestine	64%	46.00	615 / 966	44%	1.88	231 / 527
uterus	59%	13.21	100 / 170	47%	1.30	218 / 459
skin	53%	10.82	951 / 1809	52%	2.59	245 / 472
kidney	65%	17.44	58 / 89	39%	1.04	352 / 901
prostate	84%	36.38	206 / 245	18%	0.41	89 / 502
lymph node	0%	0	0 / 0	100%	88.77	29 / 29
spleen	100%	402.41	241 / 241	0%	0	0 / 0
brain	77%	28.75	2027 / 2642	23%	0.60	163 / 705
peripheral blood	100%	3177.34	926 / 929	0%	0	0 / 0
thymus	57%	19.50	372 / 653	41%	2.70	249 / 605
bladder	57%	17.57	12 / 21	39%	1.13	199 / 504
stomach	42%	9.13	150 / 359	52%	1.64	148 / 286
tonsil	0%	0	0 / 0	80%	4.94	36 / 45
esophagus	43%	9.94	624 / 1445	32%	0.68	58 / 183
adipose	72%	17.92	862 / 1204	0%	0	0 / 0
liver	45%	8.81	102 / 226	22%	0.65	89 / 406
muscle	60%	16.39	485 / 803	0%	0	0 / 0
pancreas	9%	1.44	28 / 328	43%	1.48	77 / 178
heart	36%	6.44	306 / 861	0%	0	0 / 0
blood vessel	34%	8.99	458 / 1335	0%	0	0 / 0
adrenal gland	22%	3.60	58 / 258	3%	0.04	6 / 230
eye	0%	0	0 / 0	10%	0.26	8 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0002925	Biological process	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO_0048535	Biological process	lymph node development
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0007165	Biological process	signal transduction
GO_0007267	Biological process	cell-cell signaling
GO_0006959	Biological process	humoral immune response
GO_0002876	Biological process	positive regulation of chronic inflammatory response to antigenic stimulus
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0001666	Biological process	response to hypoxia
GO_0006915	Biological process	apoptotic process
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0032496	Biological process	response to lipopolysaccharide
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0005102	Molecular function	signaling receptor binding
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	LTA
Protein name	Lymphotoxin alpha transcript variant 3 Lymphotoxin alpha Lymphotoxin alpha transcript variant 8 Truncated lymphotoxin alpha Lymphotoxin alpha transcript variant 4 Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)
Synonyms	TNFSF1 TNLG1E hCG_43681 TNFB
Description	FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM . In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. . FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. .
Accessions	P01374 Q5STV3 Q6WQV7 Q6WQV6 ENST00000383499.2 Q6FG55 ENST00000426845.1 Q45NE8 ENST00000383303.6 Q5ST95 ENST00000454550.2 A0A286SD73 Q45NE7 W6A1P7 ENST00000418386.3 ENST00000432632.5 Q45NE4 Q6WQV4 A0A286SD61 ENST00000456789.5 ENST00000383304.2 A0A286SD66 Q45NE5 A0A286SD60 Q45NE3 Q45NE9 Q6WQT9 ENST00000441939.2 Q45NE6 A0A286SD62 ENST00000454783.5 ENST00000448630.2 ENST00000436519.5 Q6WQU7 ENST00000412851.6 ENST00000400272.5

LTA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review