Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 5185.34 | 245 / 245 | 100% | 71.42 | 502 / 502 |
| brain | 100% | 6629.90 | 2636 / 2642 | 100% | 57.51 | 702 / 705 |
| liver | 100% | 6968.13 | 226 / 226 | 99% | 62.17 | 400 / 406 |
| kidney | 100% | 6113.74 | 89 / 89 | 98% | 116.79 | 886 / 901 |
| ovary | 100% | 9691.19 | 180 / 180 | 98% | 53.47 | 421 / 430 |
| adrenal gland | 100% | 3685.10 | 258 / 258 | 97% | 62.38 | 224 / 230 |
| breast | 100% | 4193.73 | 459 / 459 | 96% | 33.54 | 1070 / 1118 |
| thymus | 99% | 3037.08 | 647 / 653 | 96% | 22.93 | 578 / 605 |
| lung | 98% | 3216.49 | 565 / 578 | 89% | 47.77 | 1026 / 1155 |
| skin | 100% | 5855.18 | 1801 / 1809 | 82% | 21.84 | 387 / 472 |
| uterus | 100% | 2503.75 | 170 / 170 | 77% | 33.10 | 354 / 459 |
| pancreas | 100% | 23881.59 | 328 / 328 | 64% | 14.20 | 114 / 178 |
| bladder | 100% | 3384.29 | 21 / 21 | 57% | 20.29 | 287 / 504 |
| esophagus | 97% | 2781.72 | 1408 / 1445 | 57% | 22.84 | 105 / 183 |
| stomach | 99% | 2404.63 | 356 / 359 | 38% | 9.07 | 110 / 286 |
| intestine | 86% | 2225.30 | 827 / 966 | 35% | 8.01 | 183 / 527 |
| adipose | 100% | 4905.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 13125.89 | 803 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 28.16 | 77 / 80 |
| heart | 96% | 5902.32 | 825 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 96% | 2360.93 | 1275 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 90% | 1718.73 | 218 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 62% | 21.82 | 28 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 8.53 | 13 / 29 |
| peripheral blood | 36% | 2528.75 | 334 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0090200 | Biological process | positive regulation of release of cytochrome c from mitochondria |
| GO_1903599 | Biological process | positive regulation of autophagy of mitochondrion |
| GO_0140507 | Biological process | granzyme-mediated programmed cell death signaling pathway |
| GO_0050873 | Biological process | brown fat cell differentiation |
| GO_0090141 | Biological process | positive regulation of mitochondrial fission |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0045837 | Biological process | negative regulation of membrane potential |
| GO_0035694 | Biological process | mitochondrial protein catabolic process |
| GO_0009617 | Biological process | response to bacterium |
| GO_0051607 | Biological process | defense response to virus |
| GO_0048678 | Biological process | response to axon injury |
| GO_2000378 | Biological process | negative regulation of reactive oxygen species metabolic process |
| GO_0010666 | Biological process | positive regulation of cardiac muscle cell apoptotic process |
| GO_0043069 | Biological process | negative regulation of programmed cell death |
| GO_0072593 | Biological process | reactive oxygen species metabolic process |
| GO_0051561 | Biological process | positive regulation of mitochondrial calcium ion concentration |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0048102 | Biological process | autophagic cell death |
| GO_0097345 | Biological process | mitochondrial outer membrane permeabilization |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0043653 | Biological process | mitochondrial fragmentation involved in apoptotic process |
| GO_1990144 | Biological process | intrinsic apoptotic signaling pathway in response to hypoxia |
| GO_0055093 | Biological process | response to hyperoxia |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0043068 | Biological process | positive regulation of programmed cell death |
| GO_0016239 | Biological process | positive regulation of macroautophagy |
| GO_0010508 | Biological process | positive regulation of autophagy |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0010917 | Biological process | negative regulation of mitochondrial membrane potential |
| GO_0010659 | Biological process | cardiac muscle cell apoptotic process |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0010637 | Biological process | negative regulation of mitochondrial fusion |
| GO_1903715 | Biological process | regulation of aerobic respiration |
| GO_0000422 | Biological process | autophagy of mitochondrion |
| GO_0046902 | Biological process | regulation of mitochondrial membrane permeability |
| GO_0090649 | Biological process | response to oxygen-glucose deprivation |
| GO_0021987 | Biological process | cerebral cortex development |
| GO_1902109 | Biological process | negative regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0043243 | Biological process | positive regulation of protein-containing complex disassembly |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0071279 | Biological process | cellular response to cobalt ion |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0031966 | Cellular component | mitochondrial membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0030425 | Cellular component | dendrite |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0051020 | Molecular function | GTPase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BNIP3 |
| Protein name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BCL2 interacting protein 3 BCL2/adenovirus E1B interacting protein 3 BNIP3 protein BCL2 interacting protein 3 (cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3) |
| Synonyms | NIP3 |
| Description | FUNCTION: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. . |
| Accessions | Q12983 B4DHJ7 ENST00000633835.2 Q66K24 ENST00000368636.9 ENST00000540159.4 Q6NVY4 A0A2U8ZU93 A0A0J9YW18 |
