HK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HK2 at tissue level.

III. Associated gene sets

GO_0046835Biological processcarbohydrate phosphorylation
GO_0002931Biological processresponse to ischemia
GO_0006096Biological processglycolytic process
GO_0045766Biological processpositive regulation of angiogenesis
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0006002Biological processfructose 6-phosphate metabolic process
GO_1904925Biological processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0001678Biological processintracellular glucose homeostasis
GO_0008637Biological processapoptotic mitochondrial changes
GO_0061621Biological processcanonical glycolysis
GO_0072656Biological processmaintenance of protein location in mitochondrion
GO_0001666Biological processresponse to hypoxia
GO_0072655Biological processestablishment of protein localization to mitochondrion
GO_0035795Biological processnegative regulation of mitochondrial membrane permeability
GO_0007595Biological processlactation
GO_0051156Biological processglucose 6-phosphate metabolic process
GO_0006006Biological processglucose metabolic process
GO_0046324Biological processregulation of glucose import
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005741Cellular componentmitochondrial outer membrane
GO_0004396Molecular functionhexokinase activity
GO_0005524Molecular functionATP binding
GO_0008865Molecular functionfructokinase activity
GO_0005536Molecular functionD-glucose binding
GO_0005515Molecular functionprotein binding
GO_0004340Molecular functionglucokinase activity

IV. Literature review

[source]
Gene nameHK2
Protein nameHexokinase-2 (EC 2.7.1.1) (Hexokinase type II)
Phosphotransferase (EC 2.7.1.-)
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Synonyms
DescriptionFUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate . Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis . .

AccessionsQ53SG7
E9PB90
P52789
ENST00000290573.7
ENST00000409174.1
Q53QX9