TRPV4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0047484Biological processregulation of response to osmotic stress
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0045989Biological processpositive regulation of striated muscle contraction
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0070509Biological processcalcium ion import
GO_0030036Biological processactin cytoskeleton organization
GO_0097497Biological processblood vessel endothelial cell delamination
GO_0001666Biological processresponse to hypoxia
GO_0009612Biological processresponse to mechanical stimulus
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0006816Biological processcalcium ion transport
GO_0071651Biological processpositive regulation of chemokine (C-C motif) ligand 5 production
GO_2000340Biological processpositive regulation of chemokine (C-X-C motif) ligand 1 production
GO_0006884Biological processcell volume homeostasis
GO_0046785Biological processmicrotubule polymerization
GO_0071477Biological processcellular hypotonic salinity response
GO_0071470Biological processcellular response to osmotic stress
GO_0071642Biological processpositive regulation of macrophage inflammatory protein 1 alpha production
GO_0030103Biological processvasopressin secretion
GO_0050729Biological processpositive regulation of inflammatory response
GO_0070588Biological processcalcium ion transmembrane transport
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0007043Biological processcell-cell junction assembly
GO_0043622Biological processcortical microtubule organization
GO_0002024Biological processdiet induced thermogenesis
GO_0042538Biological processhyperosmotic salinity response
GO_1902656Biological processcalcium ion import into cytosol
GO_0050891Biological processmulticellular organismal-level water homeostasis
GO_0031117Biological processpositive regulation of microtubule depolymerization
GO_0010977Biological processnegative regulation of neuron projection development
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0071476Biological processcellular hypotonic response
GO_0034605Biological processcellular response to heat
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032868Biological processresponse to insulin
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0007015Biological processactin filament organization
GO_0007231Biological processosmosensory signaling pathway
GO_1903715Biological processregulation of aerobic respiration
GO_1903444Biological processnegative regulation of brown fat cell differentiation
GO_0060351Biological processcartilage development involved in endochondral bone morphogenesis
GO_0042593Biological processglucose homeostasis
GO_0043117Biological processpositive regulation of vascular permeability
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0009986Cellular componentcell surface
GO_0005881Cellular componentcytoplasmic microtubule
GO_0030175Cellular componentfilopodium
GO_0005912Cellular componentadherens junction
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005929Cellular componentcilium
GO_0005783Cellular componentendoplasmic reticulum
GO_0032587Cellular componentruffle membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0030426Cellular componentgrowth cone
GO_0048487Molecular functionbeta-tubulin binding
GO_0042802Molecular functionidentical protein binding
GO_0042169Molecular functionSH2 domain binding
GO_0005524Molecular functionATP binding
GO_0005080Molecular functionprotein kinase C binding
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0046872Molecular functionmetal ion binding
GO_0005516Molecular functioncalmodulin binding
GO_0003779Molecular functionactin binding
GO_0008289Molecular functionlipid binding
GO_0051015Molecular functionactin filament binding
GO_0005034Molecular functionosmosensor activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity
GO_0015275Molecular functionstretch-activated, monoatomic cation-selective, calcium channel activity
GO_0019901Molecular functionprotein kinase binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameTRPV4
Protein nameTransient receptor potential cation channel subfamily V member 4
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)
SynonymsVRL2
VROAC
DescriptionFUNCTION: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity . Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification . Also activated by heat, low pH, citrate and phorbol esters . Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism . Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes . Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 . Together with PKD2, forms mechano- and thermosensitive channels in cilium . Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage . In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus . In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). .; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. .; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. .; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. .; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. .; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. .; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. .; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. .; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. .

AccessionsENST00000418703.7 [Q9HBA0-1]
ENST00000537083.5 [Q9HBA0-2]
ENST00000538125.5
ENST00000536838.1 [Q9HBA0-5]
ENST00000675670.1 [Q9HBA0-1]
Q9HBA0
ENST00000261740.7 [Q9HBA0-1]
ENST00000544971.5 [Q9HBA0-6]
A0A6Q8PFZ3
F5H6Q4
ENST00000541794.5 [Q9HBA0-4]
ENST00000674908.1