TGFB3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TGFB3 at tissue level.

III. Associated gene sets

GO_0030879Biological processmammary gland development
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0051781Biological processpositive regulation of cell division
GO_0048286Biological processlung alveolus development
GO_0042476Biological processodontogenesis
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0043627Biological processresponse to estrogen
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0062009Biological processsecondary palate development
GO_0048839Biological processinner ear development
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0007565Biological processfemale pregnancy
GO_0042704Biological processuterine wall breakdown
GO_0045216Biological processcell-cell junction organization
GO_0050714Biological processpositive regulation of protein secretion
GO_0060364Biological processfrontal suture morphogenesis
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0070483Biological processdetection of hypoxia
GO_0001666Biological processresponse to hypoxia
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0048565Biological processdigestive tract development
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_1905005Biological processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0034616Biological processresponse to laminar fluid shear stress
GO_0032570Biological processresponse to progesterone
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0060325Biological processface morphogenesis
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_1905075Biological processpositive regulation of tight junction disassembly
GO_0007435Biological processsalivary gland morphogenesis
GO_0042127Biological processregulation of cell population proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0043025Cellular componentneuronal cell body
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0009986Cellular componentcell surface
GO_0030315Cellular componentT-tubule
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0034714Molecular functiontype III transforming growth factor beta receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0034713Molecular functiontype I transforming growth factor beta receptor binding
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0005114Molecular functiontype II transforming growth factor beta receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameTGFB3
Protein nameTransforming growth factor beta 3
Transforming growth factor beta
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
Transforming growth factor-beta 3
SynonymshCG_20489
DescriptionFUNCTION: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. .

FUNCTION: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. .; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity). .; FUNCTION: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). .

AccessionsENST00000555193.1
A0A6Q8PGK5
ENST00000238682.8 [P10600-1]
Q6LDJ6
Q6TV16
A5YM40
Q6TV15
ENST00000556285.1 [P10600-2]
ENST00000556674.2 [P10600-1]
Q6TV14
P10600