CRYAB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042542Biological processresponse to hydrogen peroxide
GO_0032355Biological processresponse to estradiol
GO_0009408Biological processresponse to heat
GO_0031109Biological processmicrotubule polymerization or depolymerization
GO_0010629Biological processnegative regulation of gene expression
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0043067Biological processregulation of programmed cell death
GO_0007021Biological processtubulin complex assembly
GO_0006936Biological processmuscle contraction
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0071480Biological processcellular response to gamma radiation
GO_0051403Biological processstress-activated MAPK cascade
GO_0006457Biological processprotein folding
GO_0032387Biological processnegative regulation of intracellular transport
GO_0060561Biological processapoptotic process involved in morphogenesis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0001666Biological processresponse to hypoxia
GO_1905907Biological processnegative regulation of amyloid fibril formation
GO_0042026Biological processprotein refolding
GO_0007517Biological processmuscle organ development
GO_0002088Biological processlens development in camera-type eye
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030308Biological processnegative regulation of cell growth
GO_0097512Cellular componentcardiac myofibril
GO_0043197Cellular componentdendritic spine
GO_0030018Cellular componentZ disc
GO_0005739Cellular componentmitochondrion
GO_0043204Cellular componentperikaryon
GO_0097060Cellular componentsynaptic membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0031430Cellular componentM band
GO_0032432Cellular componentactin filament bundle
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0001540Molecular functionamyloid-beta binding
GO_0042802Molecular functionidentical protein binding
GO_0005212Molecular functionstructural constituent of eye lens
GO_0005198Molecular functionstructural molecule activity
GO_0051082Molecular functionunfolded protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCRYAB
Protein nameAlpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Alpha-crystallin B chain (Alpha(B)-crystallin)
Crystallin alpha B (Crystallin, alpha B, isoform CRA_c)
Crystallin alpha B
SynonymsCRYA2
HSPB5
HEL-S-101
hCG_1730741
DescriptionFUNCTION: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). .

FUNCTION: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. .

FUNCTION: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. .

AccessionsENST00000527950.5
ENST00000533879.2
A0A140G961
ENST00000526180.6
ENST00000529647.5
E9PJL7
ENST00000528628.5
A0A024R3B9
E9PNH7
E9PS12
C3VMY8
ENST00000528961.6
ENST00000650687.2
ENST00000651164.1
ENST00000227251.7
ENST00000531198.5
E9PRA8
ENST00000616970.5
ENST00000533971.2
ENST00000526167.5
ENST00000533280.6
ENST00000651650.1
ENST00000533475.6
ENST00000527899.6
P02511
ENST00000525823.1
V9HW27