MMP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	58% ± 20%	Explore
connective tissue cell	17 studies	56% ± 24%	Explore
myofibroblast cell	12 studies	50% ± 20%	Explore
endothelial cell of lymphatic vessel	9 studies	30% ± 10%	Explore
smooth muscle cell	9 studies	26% ± 12%	Explore
endothelial cell	8 studies	24% ± 13%	Explore
pericyte	8 studies	23% ± 8%	Explore
adventitial cell	5 studies	68% ± 16%	Explore
endothelial cell of artery	4 studies	49% ± 16%	Explore
neural crest cell	3 studies	26% ± 2%	Explore
vein endothelial cell	3 studies	28% ± 11%	Explore
extravillous trophoblast	3 studies	38% ± 3%	Explore
capillary endothelial cell	3 studies	30% ± 15%	Explore
retinal cone cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	5 studies	35% ± 14%	Explore
lung	4 studies	34% ± 15%	Explore
uterus	4 studies	22% ± 5%	Explore
adipose	4 studies	26% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	99%	54085.45	454 / 459	93%	350.42	1044 / 1118
lung	99%	42285.40	575 / 578	91%	248.38	1052 / 1155
bladder	100%	35541.43	21 / 21	82%	230.88	414 / 504
intestine	96%	24933.68	928 / 966	80%	216.23	423 / 527
esophagus	87%	24013.80	1254 / 1445	84%	213.05	154 / 183
uterus	99%	46769.01	169 / 170	71%	223.45	324 / 459
ovary	100%	39912.85	180 / 180	69%	155.96	298 / 430
skin	98%	72274.01	1776 / 1809	67%	222.07	316 / 472
stomach	75%	16450.30	268 / 359	84%	214.60	241 / 286
thymus	94%	18774.20	614 / 653	56%	64.99	341 / 605
prostate	90%	18977.65	220 / 245	58%	57.79	293 / 502
pancreas	18%	1753.03	58 / 328	93%	460.91	166 / 178
adipose	100%	67478.50	1203 / 1204	0%	0	0 / 0
blood vessel	97%	32653.04	1291 / 1335	0%	0	0 / 0
adrenal gland	65%	7830.69	168 / 258	30%	32.18	70 / 230
heart	88%	17357.97	761 / 861	0%	0	0 / 0
kidney	37%	5243.79	33 / 89	30%	42.66	269 / 901
tonsil	0%	0	0 / 0	60%	111.43	27 / 45
spleen	59%	7832.51	141 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	84.42	13 / 29
brain	0%	0	0 / 2642	36%	45.33	254 / 705
eye	0%	0	0 / 0	35%	37.25	28 / 80
muscle	25%	3283.74	197 / 803	0%	0	0 / 0
liver	0%	44.69	1 / 226	16%	20.91	64 / 406
peripheral blood	0%	9.40	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_0060346	Biological process	bone trabecula formation
GO_1903378	Biological process	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0001525	Biological process	angiogenesis
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0001955	Biological process	blood vessel maturation
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0043627	Biological process	response to estrogen
GO_0001542	Biological process	ovulation from ovarian follicle
GO_0071498	Biological process	cellular response to fluid shear stress
GO_0001553	Biological process	luteinization
GO_0007507	Biological process	heart development
GO_0051602	Biological process	response to electrical stimulus
GO_0001541	Biological process	ovarian follicle development
GO_0001957	Biological process	intramembranous ossification
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0035987	Biological process	endodermal cell differentiation
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0030198	Biological process	extracellular matrix organization
GO_0022617	Biological process	extracellular matrix disassembly
GO_1904645	Biological process	response to amyloid-beta
GO_0071347	Biological process	cellular response to interleukin-1
GO_0014012	Biological process	peripheral nervous system axon regeneration
GO_0014823	Biological process	response to activity
GO_0030574	Biological process	collagen catabolic process
GO_0048771	Biological process	tissue remodeling
GO_0055093	Biological process	response to hyperoxia
GO_0030335	Biological process	positive regulation of cell migration
GO_0060740	Biological process	prostate gland epithelium morphogenesis
GO_0001666	Biological process	response to hypoxia
GO_0006508	Biological process	proteolysis
GO_0035094	Biological process	response to nicotine
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0030163	Biological process	protein catabolic process
GO_0019538	Biological process	protein metabolic process
GO_0032526	Biological process	response to retinoic acid
GO_0045906	Biological process	negative regulation of vasoconstriction
GO_0009612	Biological process	response to mechanical stimulus
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0060325	Biological process	face morphogenesis
GO_1904707	Biological process	positive regulation of vascular associated smooth muscle cell proliferation
GO_0071492	Biological process	cellular response to UV-A
GO_0007567	Biological process	parturition
GO_0007566	Biological process	embryo implantation
GO_0048246	Biological process	macrophage chemotaxis
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0030017	Cellular component	sarcomere
GO_0005634	Cellular component	nucleus
GO_0004175	Molecular function	endopeptidase activity
GO_0008237	Molecular function	metallopeptidase activity
GO_0001968	Molecular function	fibronectin binding
GO_0008270	Molecular function	zinc ion binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	MMP2
Protein name	72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] Matrix metallopeptidase 2
Synonyms	CLG4A
Description	FUNCTION: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Accessions	ENST00000570283.1 ENST00000568715.5 H3BV48 ENST00000564864.5 ENST00000570308.5 [P08253-2] P08253 ENST00000219070.9 [P08253-1] H3BR66 ENST00000566564.1 ENST00000437642.6 [P08253-3] J3KRB7 H3BS34 ENST00000543485.5 [P08253-2]

MMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review