ALKBH5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0010793Biological processregulation of mRNA export from nucleus
GO_0007283Biological processspermatogenesis
GO_0006397Biological processmRNA processing
GO_0050684Biological processregulation of mRNA processing
GO_0061157Biological processmRNA destabilization
GO_0006417Biological processregulation of translation
GO_0006406Biological processmRNA export from nucleus
GO_0030154Biological processcell differentiation
GO_0001666Biological processresponse to hypoxia
GO_0046630Biological processgamma-delta T cell proliferation
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0042382Cellular componentparaspeckles
GO_0005634Cellular componentnucleus
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity
GO_0035515Molecular functionoxidative RNA demethylase activity
GO_1990931Molecular functionmRNA N6-methyladenosine dioxygenase activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameALKBH5
Protein nameRNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)
AlkB homolog 5, RNA demethylase
SynonymsOFOXD1
ABH5
DescriptionFUNCTION: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes . Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) . Requires molecular oxygen, alpha-ketoglutarate and iron . Demethylation of m6A mRNA affects mRNA processing and export . Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). .

AccessionsENST00000399138.5 [Q6P6C2-2]
K7ER58
ENST00000541285.1
Q6P6C2