Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 10 studies | 32% ± 12% | |
endothelial cell | 10 studies | 22% ± 7% | |
fibroblast | 7 studies | 23% ± 8% | |
B cell | 6 studies | 23% ± 4% | |
CD4-positive, alpha-beta T cell | 6 studies | 19% ± 3% | |
smooth muscle cell | 6 studies | 19% ± 5% | |
pericyte | 5 studies | 19% ± 2% | |
epithelial cell | 5 studies | 33% ± 15% | |
pancreatic A cell | 4 studies | 34% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 21% ± 3% | |
memory B cell | 4 studies | 18% ± 3% | |
naive B cell | 4 studies | 19% ± 2% | |
CD8-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
astrocyte | 4 studies | 26% ± 5% | |
retina horizontal cell | 4 studies | 31% ± 10% | |
type B pancreatic cell | 3 studies | 38% ± 11% | |
conventional dendritic cell | 3 studies | 26% ± 12% | |
neuron | 3 studies | 29% ± 9% | |
retinal bipolar neuron | 3 studies | 30% ± 8% | |
retinal ganglion cell | 3 studies | 60% ± 22% | |
plasmacytoid dendritic cell | 3 studies | 19% ± 3% | |
basal cell | 3 studies | 23% ± 8% | |
retinal cone cell | 3 studies | 44% ± 14% | |
Mueller cell | 3 studies | 22% ± 2% | |
macrophage | 3 studies | 19% ± 1% | |
glutamatergic neuron | 3 studies | 38% ± 17% | |
abnormal cell | 3 studies | 19% ± 2% | |
enteroendocrine cell | 3 studies | 26% ± 10% | |
goblet cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 4671.82 | 459 / 459 | 100% | 103.33 | 1118 / 1118 |
esophagus | 100% | 5794.76 | 1445 / 1445 | 100% | 75.19 | 183 / 183 |
intestine | 100% | 6371.06 | 966 / 966 | 100% | 64.28 | 527 / 527 |
liver | 100% | 3690.69 | 226 / 226 | 100% | 60.51 | 406 / 406 |
ovary | 100% | 5078.70 | 180 / 180 | 100% | 71.03 | 430 / 430 |
pancreas | 100% | 2733.93 | 328 / 328 | 100% | 79.65 | 178 / 178 |
prostate | 100% | 6307.00 | 245 / 245 | 100% | 112.00 | 502 / 502 |
stomach | 100% | 4422.81 | 359 / 359 | 100% | 61.78 | 286 / 286 |
thymus | 100% | 5370.88 | 653 / 653 | 100% | 105.84 | 605 / 605 |
lung | 100% | 4603.34 | 577 / 578 | 100% | 86.97 | 1155 / 1155 |
bladder | 100% | 6491.43 | 21 / 21 | 100% | 76.40 | 503 / 504 |
uterus | 100% | 6298.92 | 170 / 170 | 100% | 111.27 | 458 / 459 |
kidney | 100% | 4862.97 | 89 / 89 | 100% | 105.99 | 899 / 901 |
brain | 100% | 5315.57 | 2636 / 2642 | 100% | 90.75 | 705 / 705 |
skin | 100% | 4200.22 | 1808 / 1809 | 100% | 102.75 | 471 / 472 |
adrenal gland | 100% | 6151.54 | 258 / 258 | 100% | 95.80 | 229 / 230 |
adipose | 100% | 4848.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 101.00 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 91.44 | 29 / 29 |
muscle | 100% | 14264.18 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5009.82 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 93.36 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 31.02 | 1 / 1 |
blood vessel | 100% | 6468.75 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 7439.15 | 854 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 4166.55 | 911 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0140694 | Biological process | non-membrane-bounded organelle assembly |
GO_0010793 | Biological process | regulation of mRNA export from nucleus |
GO_0007283 | Biological process | spermatogenesis |
GO_0006397 | Biological process | mRNA processing |
GO_0050684 | Biological process | regulation of mRNA processing |
GO_0061157 | Biological process | mRNA destabilization |
GO_0006417 | Biological process | regulation of translation |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_0030154 | Biological process | cell differentiation |
GO_0001666 | Biological process | response to hypoxia |
GO_0046630 | Biological process | gamma-delta T cell proliferation |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0042382 | Cellular component | paraspeckles |
GO_0005634 | Cellular component | nucleus |
GO_0016706 | Molecular function | 2-oxoglutarate-dependent dioxygenase activity |
GO_0035515 | Molecular function | oxidative RNA demethylase activity |
GO_1990931 | Molecular function | mRNA N6-methyladenosine dioxygenase activity |
GO_0140693 | Molecular function | molecular condensate scaffold activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | ALKBH5 |
Protein name | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) AlkB homolog 5, RNA demethylase |
Synonyms | OFOXD1 ABH5 |
Description | FUNCTION: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes . Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) . Requires molecular oxygen, alpha-ketoglutarate and iron . Demethylation of m6A mRNA affects mRNA processing and export . Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). . |
Accessions | ENST00000399138.5 [Q6P6C2-2] K7ER58 ENST00000541285.1 Q6P6C2 |