CITED2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	28 studies	30% ± 10%	Explore
natural killer cell	26 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	26 studies	28% ± 8%	Explore
fibroblast	24 studies	38% ± 16%	Explore
macrophage	23 studies	33% ± 13%	Explore
T cell	21 studies	28% ± 12%	Explore
regulatory T cell	18 studies	26% ± 10%	Explore
smooth muscle cell	16 studies	27% ± 7%	Explore
classical monocyte	16 studies	26% ± 11%	Explore
pericyte	16 studies	32% ± 13%	Explore
plasma cell	15 studies	38% ± 16%	Explore
non-classical monocyte	14 studies	26% ± 8%	Explore
mature NK T cell	13 studies	30% ± 9%	Explore
endothelial cell	13 studies	23% ± 6%	Explore
B cell	12 studies	22% ± 9%	Explore
ciliated cell	12 studies	34% ± 21%	Explore
epithelial cell	12 studies	39% ± 18%	Explore
gamma-delta T cell	12 studies	30% ± 12%	Explore
monocyte	11 studies	27% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 8%	Explore
connective tissue cell	11 studies	33% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	24% ± 10%	Explore
mast cell	10 studies	21% ± 6%	Explore
mucosal invariant T cell	10 studies	30% ± 9%	Explore
myofibroblast cell	10 studies	29% ± 9%	Explore
type II pneumocyte	9 studies	42% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	31% ± 11%	Explore
type I pneumocyte	8 studies	32% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	29% ± 15%	Explore
plasmablast	7 studies	36% ± 12%	Explore
conventional dendritic cell	7 studies	32% ± 10%	Explore
mesothelial cell	7 studies	43% ± 19%	Explore
IgA plasma cell	7 studies	30% ± 14%	Explore
IgG plasma cell	7 studies	29% ± 12%	Explore
myeloid cell	7 studies	31% ± 10%	Explore
basal cell	7 studies	34% ± 21%	Explore
T follicular helper cell	7 studies	38% ± 13%	Explore
innate lymphoid cell	7 studies	29% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 10%	Explore
alveolar macrophage	6 studies	46% ± 18%	Explore
CD4-positive helper T cell	6 studies	25% ± 12%	Explore
leukocyte	6 studies	25% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	30% ± 8%	Explore
hematopoietic precursor cell	5 studies	29% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	29% ± 7%	Explore
progenitor cell	5 studies	29% ± 15%	Explore
endothelial cell of vascular tree	5 studies	19% ± 2%	Explore
T-helper 17 cell	5 studies	39% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	32% ± 4%	Explore
memory B cell	5 studies	19% ± 4%	Explore
podocyte	4 studies	58% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	23% ± 9%	Explore
dendritic cell	4 studies	31% ± 4%	Explore
group 3 innate lymphoid cell	4 studies	49% ± 8%	Explore
erythrocyte	4 studies	34% ± 14%	Explore
ionocyte	3 studies	25% ± 4%	Explore
squamous epithelial cell	3 studies	52% ± 18%	Explore
pancreatic A cell	3 studies	25% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	29% ± 4%	Explore
mononuclear phagocyte	3 studies	34% ± 24%	Explore
epithelial cell of proximal tubule	3 studies	31% ± 6%	Explore
enterocyte	3 studies	18% ± 1%	Explore
abnormal cell	3 studies	26% ± 3%	Explore
extravillous trophoblast	3 studies	60% ± 16%	Explore
placental villous trophoblast	3 studies	29% ± 6%	Explore
hematopoietic stem cell	3 studies	20% ± 3%	Explore
neuron	3 studies	52% ± 16%	Explore
retina horizontal cell	3 studies	28% ± 15%	Explore
retinal rod cell	3 studies	43% ± 19%	Explore
intraepithelial lymphocyte	3 studies	24% ± 6%	Explore
GABAergic neuron	3 studies	20% ± 2%	Explore
granulocyte	3 studies	25% ± 11%	Explore
intestinal crypt stem cell	3 studies	18% ± 1%	Explore
glial cell	3 studies	27% ± 8%	Explore
interneuron	3 studies	21% ± 5%	Explore
T-helper 1 cell	3 studies	40% ± 11%	Explore
plasmacytoid dendritic cell	3 studies	17% ± 1%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	3 studies	24% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	27% ± 8%	Explore
peripheral blood	12 studies	25% ± 6%	Explore
intestine	8 studies	31% ± 9%	Explore
kidney	5 studies	23% ± 6%	Explore
liver	5 studies	30% ± 20%	Explore
bone marrow	4 studies	21% ± 5%	Explore
eye	4 studies	35% ± 11%	Explore
uterus	4 studies	32% ± 9%	Explore
lymph node	4 studies	33% ± 6%	Explore
pancreas	3 studies	23% ± 3%	Explore
placenta	3 studies	42% ± 12%	Explore
adipose	3 studies	20% ± 5%	Explore
thymus	3 studies	24% ± 6%	Explore
breast	3 studies	30% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	19651.79	180 / 180	100%	124.70	428 / 430
breast	100%	9793.88	458 / 459	98%	133.18	1092 / 1118
kidney	100%	4901.99	89 / 89	97%	164.36	872 / 901
thymus	100%	13076.49	653 / 653	96%	213.17	580 / 605
lung	99%	10302.67	574 / 578	94%	106.04	1085 / 1155
esophagus	96%	7469.22	1385 / 1445	88%	51.93	161 / 183
pancreas	92%	2864.88	303 / 328	91%	53.45	162 / 178
prostate	84%	2619.65	205 / 245	99%	121.56	495 / 502
bladder	95%	2788.71	20 / 21	87%	59.53	437 / 504
adrenal gland	99%	8107.36	255 / 258	82%	81.81	189 / 230
intestine	99%	5922.82	953 / 966	81%	36.05	428 / 527
skin	100%	16464.89	1807 / 1809	80%	42.80	377 / 472
uterus	96%	11158.25	163 / 170	82%	49.05	376 / 459
stomach	89%	4246.83	321 / 359	82%	42.42	235 / 286
liver	93%	7768.81	210 / 226	69%	35.30	279 / 406
brain	35%	1091.92	916 / 2642	85%	41.61	600 / 705
adipose	100%	7952.42	1201 / 1204	0%	0	0 / 0
spleen	100%	8081.95	240 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	53.34	41 / 45
blood vessel	91%	3661.19	1215 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	35.98	24 / 29
muscle	77%	4520.98	621 / 803	0%	0	0 / 0
heart	77%	2994.71	659 / 861	0%	0	0 / 0
peripheral blood	57%	1601.22	527 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	19%	8.08	15 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0048821	Biological process	erythrocyte development
GO_0060136	Biological process	embryonic process involved in female pregnancy
GO_0003151	Biological process	outflow tract morphogenesis
GO_0035802	Biological process	adrenal cortex formation
GO_0008283	Biological process	cell population proliferation
GO_0060349	Biological process	bone morphogenesis
GO_0070986	Biological process	left/right axis specification
GO_0043627	Biological process	response to estrogen
GO_0048596	Biological process	embryonic camera-type eye morphogenesis
GO_0010629	Biological process	negative regulation of gene expression
GO_0007507	Biological process	heart development
GO_0046697	Biological process	decidualization
GO_0001892	Biological process	embryonic placenta development
GO_0001947	Biological process	heart looping
GO_0007368	Biological process	determination of left/right symmetry
GO_0003156	Biological process	regulation of animal organ formation
GO_0001829	Biological process	trophectodermal cell differentiation
GO_0035360	Biological process	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO_0060044	Biological process	negative regulation of cardiac muscle cell proliferation
GO_0010628	Biological process	positive regulation of gene expression
GO_0071456	Biological process	cellular response to hypoxia
GO_0001570	Biological process	vasculogenesis
GO_0034405	Biological process	response to fluid shear stress
GO_0001889	Biological process	liver development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060971	Biological process	embryonic heart tube left/right pattern formation
GO_0048536	Biological process	spleen development
GO_0030851	Biological process	granulocyte differentiation
GO_0060972	Biological process	left/right pattern formation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0001666	Biological process	response to hypoxia
GO_0007422	Biological process	peripheral nervous system development
GO_0003197	Biological process	endocardial cushion development
GO_0060065	Biological process	uterus development
GO_0048538	Biological process	thymus development
GO_0001843	Biological process	neural tube closure
GO_0060412	Biological process	ventricular septum morphogenesis
GO_2000020	Biological process	positive regulation of male gonad development
GO_0061308	Biological process	cardiac neural crest cell development involved in heart development
GO_0038092	Biological process	nodal signaling pathway
GO_0061156	Biological process	pulmonary artery morphogenesis
GO_0007417	Biological process	central nervous system development
GO_0008584	Biological process	male gonad development
GO_0030336	Biological process	negative regulation of cell migration
GO_0090398	Biological process	cellular senescence
GO_0002089	Biological process	lens morphogenesis in camera-type eye
GO_0009612	Biological process	response to mechanical stimulus
GO_0003140	Biological process	determination of left/right asymmetry in lateral mesoderm
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0021602	Biological process	cranial nerve morphogenesis
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0007530	Biological process	sex determination
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0022409	Biological process	positive regulation of cell-cell adhesion
GO_0045787	Biological process	positive regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0140677	Molecular function	molecular function activator activity
GO_0019904	Molecular function	protein domain specific binding
GO_0050693	Molecular function	LBD domain binding
GO_0003682	Molecular function	chromatin binding
GO_0046332	Molecular function	SMAD binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0035035	Molecular function	histone acetyltransferase binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CITED2
Protein name	Cbp/p300-interacting transactivator 2 Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj)
Synonyms	MRG1 hCG_32930
Description	FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. .
Accessions	ENST00000537332.2 A0A0A0MTM3 Q99967 D9ZGF1 ENST00000536159.2 [Q99967-1] ENST00000367651.4 [Q99967-1]

CITED2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review