CASP9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASP9 at tissue level.

III. Associated gene sets

GO_0008635Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO_0032355Biological processresponse to estradiol
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0034349Biological processglial cell apoptotic process
GO_0002931Biological processresponse to ischemia
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0034644Biological processcellular response to UV
GO_0006974Biological processDNA damage response
GO_0016485Biological processprotein processing
GO_0001822Biological processkidney development
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0051402Biological processneuron apoptotic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0071887Biological processleukocyte apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_1904019Biological processepithelial cell apoptotic process
GO_0006915Biological processapoptotic process
GO_0032025Biological processresponse to cobalt ion
GO_0044346Biological processfibroblast apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030220Biological processplatelet formation
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0032496Biological processresponse to lipopolysaccharide
GO_0051604Biological processprotein maturation
GO_0008303Cellular componentcaspase complex
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0043293Cellular componentapoptosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0008233Molecular functionpeptidase activity
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0019901Molecular functionprotein kinase binding
GO_0097199Molecular functioncysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameCASP9
Protein nameCaspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Caspase 9
SynonymsMCH6
DescriptionFUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). .; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. .

AccessionsP55211
ENST00000447522.5
Q5JRU8
ENST00000375890.8 [P55211-4]
ENST00000424908.5
ENST00000469637.1
ENST00000400777.7
ENST00000348549.9 [P55211-2]
A0A087WX72
H0Y3S8
F8VWA5
Q5JRU2
ENST00000440484.1
ENST00000333868.10 [P55211-1]
H0Y6Y2
ENST00000474305.2
F8VVS7
ENST00000546424.5