TM9SF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051453Biological processregulation of intracellular pH
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_0007155Biological processcell adhesion
GO_0001666Biological processresponse to hypoxia
GO_0072657Biological processprotein localization to membrane
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0070072Biological processvacuolar proton-transporting V-type ATPase complex assembly
GO_0006909Biological processphagocytosis
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTM9SF4
Protein nameTransmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)
Transmembrane 9 superfamily member
SynonymsKIAA0255
hCG_38809
TUCAP1
DescriptionFUNCTION: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface . Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells . Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells . .

AccessionsENST00000398022.7
ENST00000442842.5
ENST00000217315.9
A0A0C4DFM1
ENST00000450829.5
Q92544
F2Z2L1