ADM | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	22 studies	29% ± 15%	Explore
endothelial cell	20 studies	25% ± 10%	Explore
macrophage	13 studies	25% ± 8%	Explore
basal cell	13 studies	26% ± 8%	Explore
classical monocyte	10 studies	24% ± 8%	Explore
epithelial cell	9 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	34% ± 11%	Explore
capillary endothelial cell	8 studies	23% ± 9%	Explore
endothelial cell of vascular tree	8 studies	20% ± 4%	Explore
monocyte	7 studies	25% ± 14%	Explore
non-classical monocyte	7 studies	21% ± 6%	Explore
connective tissue cell	5 studies	25% ± 7%	Explore
adipocyte	5 studies	33% ± 23%	Explore
astrocyte	4 studies	23% ± 6%	Explore
pericyte	4 studies	32% ± 11%	Explore
adventitial cell	4 studies	25% ± 13%	Explore
secretory cell	4 studies	28% ± 4%	Explore
squamous epithelial cell	3 studies	33% ± 17%	Explore
endothelial cell of artery	3 studies	26% ± 4%	Explore
glomerular endothelial cell	3 studies	36% ± 12%	Explore
renal alpha-intercalated cell	3 studies	30% ± 17%	Explore
abnormal cell	3 studies	39% ± 11%	Explore
extravillous trophoblast	3 studies	77% ± 5%	Explore
placental villous trophoblast	3 studies	41% ± 19%	Explore
myeloid cell	3 studies	25% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	20% ± 5%	Explore
goblet cell	3 studies	24% ± 10%	Explore
keratinocyte	3 studies	25% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	23% ± 3%	Explore
skin	4 studies	19% ± 2%	Explore
placenta	3 studies	45% ± 13%	Explore
prostate	3 studies	30% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	88%	6964.66	78 / 89	83%	205.66	751 / 901
bladder	90%	5762.71	19 / 21	80%	75.39	403 / 504
lung	93%	10137.58	539 / 578	65%	79.49	745 / 1155
skin	97%	22303.53	1755 / 1809	53%	32.23	250 / 472
esophagus	75%	3665.65	1081 / 1445	70%	62.00	129 / 183
intestine	68%	3337.83	656 / 966	66%	32.71	346 / 527
thymus	58%	3333.16	376 / 653	74%	54.29	448 / 605
uterus	43%	2369.44	73 / 170	87%	121.00	399 / 459
breast	97%	13492.46	447 / 459	28%	14.65	309 / 1118
adrenal gland	23%	1007.84	59 / 258	78%	105.27	179 / 230
ureter	0%	0	0 / 0	100%	23.23	1 / 1
adipose	100%	22253.15	1201 / 1204	0%	0	0 / 0
stomach	50%	2346.94	179 / 359	45%	18.17	128 / 286
tonsil	0%	0	0 / 0	91%	140.08	41 / 45
peripheral blood	84%	8682.41	778 / 929	0%	0	0 / 0
pancreas	3%	81.81	10 / 328	72%	56.13	128 / 178
ovary	34%	1562.68	62 / 180	39%	17.01	169 / 430
blood vessel	73%	6198.47	968 / 1335	0%	0	0 / 0
liver	34%	2822.19	76 / 226	36%	18.09	148 / 406
heart	61%	4129.90	522 / 861	0%	0	0 / 0
prostate	22%	1218.70	54 / 245	32%	13.81	162 / 502
muscle	52%	2691.89	419 / 803	0%	0	0 / 0
spleen	51%	1927.30	122 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	19.74	13 / 29
brain	13%	512.34	354 / 2642	31%	31.27	221 / 705
eye	0%	0	0 / 0	34%	11.03	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0031623	Biological process	receptor internalization
GO_0006954	Biological process	inflammatory response
GO_0008283	Biological process	cell population proliferation
GO_0008209	Biological process	androgen metabolic process
GO_1990410	Biological process	adrenomedullin receptor signaling pathway
GO_0007507	Biological process	heart development
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0035809	Biological process	regulation of urine volume
GO_0043116	Biological process	negative regulation of vascular permeability
GO_0007165	Biological process	signal transduction
GO_0032868	Biological process	response to insulin
GO_0019933	Biological process	cAMP-mediated signaling
GO_0001570	Biological process	vasculogenesis
GO_0002026	Biological process	regulation of the force of heart contraction
GO_0097084	Biological process	vascular associated smooth muscle cell development
GO_0031100	Biological process	animal organ regeneration
GO_0031102	Biological process	neuron projection regeneration
GO_0007565	Biological process	female pregnancy
GO_0042594	Biological process	response to starvation
GO_0003073	Biological process	regulation of systemic arterial blood pressure
GO_0051384	Biological process	response to glucocorticoid
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0001666	Biological process	response to hypoxia
GO_0001843	Biological process	neural tube closure
GO_0060670	Biological process	branching involved in labyrinthine layer morphogenesis
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0002031	Biological process	G protein-coupled receptor internalization
GO_2001214	Biological process	positive regulation of vasculogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045906	Biological process	negative regulation of vasoconstriction
GO_0048589	Biological process	developmental growth
GO_2000184	Biological process	positive regulation of progesterone biosynthetic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0010460	Biological process	positive regulation of heart rate
GO_0032496	Biological process	response to lipopolysaccharide
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005737	Cellular component	cytoplasm
GO_0005179	Molecular function	hormone activity
GO_0005102	Molecular function	signaling receptor binding
GO_0031700	Molecular function	adrenomedullin receptor binding

IV. Literature review

[source]

Gene name	ADM
Protein name	Pro-adrenomedullin Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] Adrenomedullin
Synonyms	AM
Description	FUNCTION: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Accessions	P35318 ENST00000524948.5 E9PQE6 E9PL83 ENST00000534464.1 ENST00000530439.1 ENST00000528655.5 ENST00000526492.4 E9PML4 E9PQT2 ENST00000525063.2 ENST00000528544.1 ENST00000278175.10

ADM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review