Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 16 studies | 28% ± 9% | |
| endothelial cell | 9 studies | 25% ± 7% | |
| vein endothelial cell | 9 studies | 25% ± 10% | |
| connective tissue cell | 8 studies | 26% ± 15% | |
| macrophage | 7 studies | 37% ± 21% | |
| endothelial cell of vascular tree | 4 studies | 23% ± 2% | |
| parietal epithelial cell | 3 studies | 44% ± 21% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney | 3 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 8643.03 | 89 / 89 | 90% | 290.41 | 811 / 901 |
| breast | 98% | 1796.95 | 449 / 459 | 79% | 24.80 | 886 / 1118 |
| pancreas | 74% | 1035.40 | 244 / 328 | 87% | 33.91 | 154 / 178 |
| adrenal gland | 100% | 5736.22 | 258 / 258 | 57% | 41.68 | 130 / 230 |
| lung | 79% | 2390.65 | 459 / 578 | 75% | 23.70 | 864 / 1155 |
| ovary | 99% | 3443.15 | 178 / 180 | 47% | 10.40 | 201 / 430 |
| bladder | 90% | 1685.71 | 19 / 21 | 44% | 10.54 | 221 / 504 |
| intestine | 84% | 1275.85 | 812 / 966 | 42% | 8.30 | 219 / 527 |
| thymus | 88% | 1151.45 | 574 / 653 | 37% | 8.23 | 224 / 605 |
| esophagus | 71% | 746.41 | 1030 / 1445 | 54% | 14.76 | 98 / 183 |
| prostate | 76% | 958.68 | 187 / 245 | 37% | 5.57 | 184 / 502 |
| uterus | 69% | 753.59 | 118 / 170 | 42% | 13.56 | 192 / 459 |
| brain | 30% | 226.83 | 781 / 2642 | 73% | 33.22 | 517 / 705 |
| stomach | 44% | 455.20 | 158 / 359 | 58% | 11.22 | 165 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 43.15 | 29 / 29 |
| spleen | 100% | 21490.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 3233.42 | 1188 / 1204 | 0% | 0 | 0 / 0 |
| skin | 43% | 339.83 | 773 / 1809 | 54% | 14.86 | 257 / 472 |
| liver | 44% | 361.92 | 100 / 226 | 50% | 18.95 | 205 / 406 |
| blood vessel | 91% | 2556.72 | 1213 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 83.78 | 30 / 45 |
| heart | 59% | 634.22 | 509 / 861 | 0% | 0 | 0 / 0 |
| muscle | 22% | 179.67 | 174 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.90 | 7 / 80 |
| peripheral blood | 6% | 36.58 | 52 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007584 | Biological process | response to nutrient |
| GO_0022614 | Biological process | membrane to membrane docking |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0002544 | Biological process | chronic inflammatory response |
| GO_0006954 | Biological process | inflammatory response |
| GO_0010212 | Biological process | response to ionizing radiation |
| GO_0033631 | Biological process | cell-cell adhesion mediated by integrin |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0007155 | Biological process | cell adhesion |
| GO_0034113 | Biological process | heterotypic cell-cell adhesion |
| GO_0045471 | Biological process | response to ethanol |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0035094 | Biological process | response to nicotine |
| GO_0010043 | Biological process | response to zinc ion |
| GO_0050901 | Biological process | leukocyte tethering or rolling |
| GO_0060945 | Biological process | cardiac neuron differentiation |
| GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
| GO_0060384 | Biological process | innervation |
| GO_0007157 | Biological process | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0009308 | Biological process | amine metabolic process |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0005902 | Cellular component | microvillus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0002102 | Cellular component | podosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0071065 | Cellular component | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex |
| GO_0009986 | Cellular component | cell surface |
| GO_0030175 | Cellular component | filopodium |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0008131 | Molecular function | primary amine oxidase activity |
| GO_0005178 | Molecular function | integrin binding |
| GO_0098631 | Molecular function | cell adhesion mediator activity |
| GO_0050839 | Molecular function | cell adhesion molecule binding |
| Gene name | VCAM1 |
| Protein name | Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1] Vascular cell adhesion molecule 1 |
| Synonyms | |
| Description | FUNCTION: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation . Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins . During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration . Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation . . |
| Accessions | E9PDD2 A0A3B3ISS8 ENST00000347652.6 [P19320-2] ENST00000650339.1 G0ZFQ0 ENST00000294728.7 [P19320-1] F2YYR6 F8UV74 ENST00000370115.1 F8UU18 P19320 ENST00000370119.8 [P19320-3] G0ZI12 |
