EGLN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0018401Biological processpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO_0001558Biological processregulation of cell growth
GO_0001666Biological processresponse to hypoxia
GO_0030520Biological processestrogen receptor signaling pathway
GO_0043523Biological processregulation of neuron apoptotic process
GO_0071456Biological processcellular response to hypoxia
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019826Molecular functionoxygen sensor activity
GO_0008198Molecular functionferrous iron binding
GO_0005515Molecular functionprotein binding
GO_0160082Molecular functionhypoxia-inducible factor-proline dioxygenase activity
GO_0031418Molecular functionL-ascorbic acid binding
GO_0031545Molecular functionpeptidyl-proline 4-dioxygenase activity
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity

IV. Literature review

[source]
Gene nameEGLN2
Protein nameAlternative protein EGLN2
Egl-9 family hypoxia inducible factor 2
Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29)
SynonymsEIT6
DescriptionFUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A . Target proteins are preferentially recognized via a LXXLAP motif . Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins . Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A . Also hydroxylates HIF2A . Has a preference for the CODD site for both HIF1A and HIF2A . Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex . Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes . EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle . Also regulates susceptibility to normoxic oxidative neuronal death . Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation . Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions . Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). .

AccessionsM0QXM8
ENST00000596517.1
ENST00000406058.6 [Q96KS0-1]
ENST00000597746.5
Q96KS0
ENST00000593397.1
ENST00000303961.9 [Q96KS0-1]
M0R350
ENST00000594380.1
ENST00000595051.1
M0R035
ENST00000598654.1
M0R1W4
ENST00000601733.1
ENST00000593972.1
M0R0Z6
ENST00000593525.1
ENST00000595621.1
ENST00000594140.5
M0R1L0
ENST00000593726.5 [Q96KS0-1]
M0R110
M0QXR0
M0R1A3
M0R2X9
L8EAM8
A0A0C4DGR4