RAD21 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	28% ± 8%	Explore
endothelial cell	32 studies	28% ± 10%	Explore
natural killer cell	31 studies	32% ± 13%	Explore
CD4-positive, alpha-beta T cell	29 studies	32% ± 17%	Explore
CD8-positive, alpha-beta T cell	29 studies	34% ± 16%	Explore
regulatory T cell	26 studies	37% ± 11%	Explore
T cell	23 studies	33% ± 13%	Explore
fibroblast	21 studies	28% ± 11%	Explore
macrophage	20 studies	22% ± 6%	Explore
memory B cell	19 studies	28% ± 8%	Explore
smooth muscle cell	17 studies	23% ± 5%	Explore
classical monocyte	17 studies	24% ± 10%	Explore
pericyte	17 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	30% ± 8%	Explore
non-classical monocyte	16 studies	25% ± 11%	Explore
mature NK T cell	16 studies	27% ± 8%	Explore
gamma-delta T cell	16 studies	35% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 9%	Explore
naive B cell	15 studies	30% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	31% ± 9%	Explore
epithelial cell	14 studies	36% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	33% ± 7%	Explore
conventional dendritic cell	13 studies	28% ± 16%	Explore
connective tissue cell	13 studies	26% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	37% ± 10%	Explore
mucosal invariant T cell	12 studies	31% ± 9%	Explore
mast cell	11 studies	27% ± 8%	Explore
monocyte	11 studies	21% ± 7%	Explore
type I pneumocyte	11 studies	32% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	34% ± 10%	Explore
plasmacytoid dendritic cell	11 studies	22% ± 6%	Explore
oligodendrocyte	11 studies	25% ± 9%	Explore
capillary endothelial cell	11 studies	23% ± 7%	Explore
basal cell	10 studies	27% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	35% ± 8%	Explore
endothelial cell of artery	10 studies	26% ± 4%	Explore
endothelial cell of lymphatic vessel	9 studies	22% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	43% ± 18%	Explore
myofibroblast cell	9 studies	31% ± 9%	Explore
vein endothelial cell	9 studies	24% ± 5%	Explore
plasmablast	8 studies	43% ± 18%	Explore
abnormal cell	8 studies	33% ± 6%	Explore
neuron	8 studies	40% ± 11%	Explore
glutamatergic neuron	8 studies	35% ± 22%	Explore
ciliated cell	8 studies	30% ± 12%	Explore
dendritic cell	8 studies	32% ± 17%	Explore
type II pneumocyte	7 studies	28% ± 9%	Explore
plasma cell	7 studies	26% ± 13%	Explore
mesothelial cell	7 studies	33% ± 14%	Explore
precursor B cell	7 studies	43% ± 21%	Explore
astrocyte	7 studies	24% ± 6%	Explore
endothelial cell of vascular tree	7 studies	23% ± 4%	Explore
GABAergic neuron	7 studies	35% ± 15%	Explore
leukocyte	6 studies	29% ± 9%	Explore
progenitor cell	6 studies	28% ± 11%	Explore
transit amplifying cell	6 studies	31% ± 10%	Explore
T follicular helper cell	6 studies	32% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 11%	Explore
innate lymphoid cell	6 studies	28% ± 9%	Explore
oligodendrocyte precursor cell	6 studies	24% ± 9%	Explore
erythrocyte	6 studies	31% ± 19%	Explore
hematopoietic precursor cell	5 studies	37% ± 12%	Explore
goblet cell	5 studies	23% ± 9%	Explore
microglial cell	5 studies	21% ± 5%	Explore
hematopoietic stem cell	5 studies	32% ± 8%	Explore
pro-B cell	5 studies	49% ± 9%	Explore
myeloid cell	5 studies	31% ± 11%	Explore
interneuron	5 studies	35% ± 20%	Explore
exhausted T cell	4 studies	44% ± 9%	Explore
lymphocyte	4 studies	35% ± 10%	Explore
club cell	4 studies	34% ± 7%	Explore
immature B cell	4 studies	29% ± 11%	Explore
amacrine cell	4 studies	30% ± 9%	Explore
retina horizontal cell	4 studies	28% ± 8%	Explore
retinal cone cell	4 studies	31% ± 8%	Explore
retinal rod cell	4 studies	23% ± 4%	Explore
Mueller cell	4 studies	25% ± 7%	Explore
secretory cell	4 studies	23% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	46% ± 8%	Explore
granulocyte	4 studies	23% ± 4%	Explore
enteroendocrine cell	4 studies	30% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 7%	Explore
double negative thymocyte	4 studies	43% ± 10%	Explore
ionocyte	3 studies	26% ± 7%	Explore
squamous epithelial cell	3 studies	39% ± 22%	Explore
pancreatic A cell	3 studies	46% ± 25%	Explore
type B pancreatic cell	3 studies	47% ± 30%	Explore
glomerular endothelial cell	3 studies	26% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 5%	Explore
neural crest cell	3 studies	41% ± 11%	Explore
retinal bipolar neuron	3 studies	30% ± 9%	Explore
glial cell	3 studies	32% ± 16%	Explore
retinal ganglion cell	3 studies	44% ± 21%	Explore
extravillous trophoblast	3 studies	21% ± 4%	Explore
erythroblast	3 studies	56% ± 24%	Explore
brush cell	3 studies	32% ± 12%	Explore
rod bipolar cell	3 studies	31% ± 9%	Explore
germinal center B cell	3 studies	32% ± 11%	Explore
CD4-positive helper T cell	3 studies	29% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	58% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 10%	Explore
T-helper 17 cell	3 studies	41% ± 24%	Explore
neutrophil	3 studies	16% ± 1%	Explore
T-helper 1 cell	3 studies	39% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	41% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	31% ± 9%	Explore
lung	13 studies	26% ± 7%	Explore
brain	12 studies	29% ± 14%	Explore
eye	7 studies	25% ± 6%	Explore
intestine	6 studies	25% ± 9%	Explore
lymph node	6 studies	28% ± 7%	Explore
kidney	5 studies	26% ± 6%	Explore
bone marrow	4 studies	30% ± 10%	Explore
liver	4 studies	37% ± 21%	Explore
pancreas	3 studies	45% ± 24%	Explore
placenta	3 studies	24% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	11069.64	1445 / 1445	100%	156.50	183 / 183
lung	100%	8924.88	578 / 578	100%	134.15	1155 / 1155
ovary	100%	8672.31	180 / 180	100%	124.27	430 / 430
brain	100%	9280.04	2640 / 2642	100%	137.39	705 / 705
breast	100%	10083.89	459 / 459	100%	251.34	1116 / 1118
stomach	100%	7568.01	359 / 359	99%	125.94	283 / 286
uterus	100%	8507.24	170 / 170	99%	141.80	453 / 459
thymus	100%	10224.16	653 / 653	99%	102.19	597 / 605
bladder	100%	9298.62	21 / 21	99%	118.63	497 / 504
intestine	100%	10140.17	966 / 966	98%	126.25	519 / 527
prostate	100%	6542.09	244 / 245	98%	88.61	490 / 502
adrenal gland	100%	11197.71	258 / 258	97%	77.94	223 / 230
skin	100%	8705.31	1807 / 1809	94%	113.88	444 / 472
kidney	100%	4817.89	89 / 89	94%	63.73	846 / 901
pancreas	93%	2616.95	305 / 328	98%	87.06	175 / 178
liver	99%	3310.94	223 / 226	93%	63.88	376 / 406
adipose	100%	10022.14	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	120.41	29 / 29
spleen	100%	7316.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	148.26	45 / 45
ureter	0%	0	0 / 0	100%	52.59	1 / 1
blood vessel	100%	7338.20	1334 / 1335	0%	0	0 / 0
muscle	100%	6774.68	802 / 803	0%	0	0 / 0
heart	97%	5830.55	832 / 861	0%	0	0 / 0
peripheral blood	92%	7856.12	859 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	72.96	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034089	Biological process	establishment of meiotic sister chromatid cohesion
GO_0007062	Biological process	sister chromatid cohesion
GO_1990414	Biological process	replication-born double-strand break repair via sister chromatid exchange
GO_0007059	Biological process	chromosome segregation
GO_0006302	Biological process	double-strand break repair
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007131	Biological process	reciprocal meiotic recombination
GO_0051301	Biological process	cell division
GO_0034087	Biological process	establishment of mitotic sister chromatid cohesion
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0045876	Biological process	positive regulation of sister chromatid cohesion
GO_0001666	Biological process	response to hypoxia
GO_0140588	Biological process	chromatin looping
GO_0071168	Biological process	protein localization to chromatin
GO_0045841	Biological process	negative regulation of mitotic metaphase/anaphase transition
GO_0006915	Biological process	apoptotic process
GO_0006310	Biological process	DNA recombination
GO_0034351	Biological process	negative regulation of glial cell apoptotic process
GO_0010972	Biological process	negative regulation of G2/M transition of mitotic cell cycle
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0000775	Cellular component	chromosome, centromeric region
GO_0030496	Cellular component	midbody
GO_0008278	Cellular component	cohesin complex
GO_0000922	Cellular component	spindle pole
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0016363	Cellular component	nuclear matrix
GO_0005829	Cellular component	cytosol
GO_0030892	Cellular component	mitotic cohesin complex
GO_0030893	Cellular component	meiotic cohesin complex
GO_0005694	Cellular component	chromosome
GO_0000794	Cellular component	condensed nuclear chromosome
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0003682	Molecular function	chromatin binding
GO_0106222	Molecular function	lncRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RAD21
Protein name	Double-strand-break repair protein rad21 homolog Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] RAD21 cohesin complex component
Synonyms	KIAA0078 NXP1 SCC1 HR21
Description	FUNCTION: [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions . The cohesin complex may also play a role in spindle pole assembly during mitosis . In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter . May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). .; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. .
Accessions	A0A8I5KWV3 ENST00000297338.7 ENST00000522699.2 E5RJW1 E5RJK5 E5RG18 O60216 ENST00000517749.2 ENST00000519837 ENST00000517485.6 ENST00000520992.6 ENST00000687902.1 E5RFV8 ENST00000687358.1 ENST00000522699 ENST00000517749 E5RIN7 ENST00000517485 ENST00000519837.6 ENST00000520992

RAD21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review