PLOD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLOD1 at tissue level.

III. Associated gene sets

GO_0008544Biological processepidermis development
GO_0017185Biological processpeptidyl-lysine hydroxylation
GO_0001666Biological processresponse to hypoxia
GO_0006493Biological processprotein O-linked glycosylation
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_1902494Cellular componentcatalytic complex
GO_0030867Cellular componentrough endoplasmic reticulum membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033823Molecular functionprocollagen glucosyltransferase activity
GO_0005506Molecular functioniron ion binding
GO_0008475Molecular functionprocollagen-lysine 5-dioxygenase activity
GO_0005515Molecular functionprotein binding
GO_0031418Molecular functionL-ascorbic acid binding

IV. Literature review

[source]
Gene namePLOD1
Protein nameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)
SynonymsLLH
PLOD
DescriptionFUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens . These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). .

AccessionsENST00000449038.5
Q5JXB8
Q02809
Q5JXB7
ENST00000196061.5 [Q02809-1]
ENST00000429000.6