PDLIM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030011Biological processmaintenance of cell polarity
GO_0007507Biological processheart development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0061061Biological processmuscle structure development
GO_0010761Biological processfibroblast migration
GO_0030036Biological processactin cytoskeleton organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001666Biological processresponse to hypoxia
GO_0030950Biological processestablishment or maintenance of actin cytoskeleton polarity
GO_0043149Biological processstress fiber assembly
GO_0098609Biological processcell-cell adhesion
GO_0006979Biological processresponse to oxidative stress
GO_0005856Cellular componentcytoskeleton
GO_0031941Cellular componentfilamentous actin
GO_0030018Cellular componentZ disc
GO_0005925Cellular componentfocal adhesion
GO_0001725Cellular componentstress fiber
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0051371Molecular functionmuscle alpha-actinin binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePDLIM1
Protein nameEpididymis secretory protein Li 112 (PDZ and LIM domain 1 (Elfin), isoform CRA_a)
PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)
SynonymsHEL-S-112
CLP36
CLIM1
hCG_39492
DescriptionFUNCTION: Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton . Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). .

AccessionsENST00000329399.7
O00151
V9HW92