RYR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	79% ± 17%	Explore
oligodendrocyte	11 studies	37% ± 18%	Explore
smooth muscle cell	10 studies	48% ± 22%	Explore
GABAergic neuron	9 studies	65% ± 24%	Explore
pericyte	9 studies	37% ± 27%	Explore
fibroblast	9 studies	43% ± 22%	Explore
neuron	7 studies	36% ± 19%	Explore
microglial cell	7 studies	32% ± 20%	Explore
retinal ganglion cell	7 studies	64% ± 29%	Explore
endothelial cell	6 studies	52% ± 21%	Explore
interneuron	6 studies	49% ± 27%	Explore
cardiac muscle cell	6 studies	93% ± 10%	Explore
mesothelial cell	6 studies	35% ± 6%	Explore
retinal bipolar neuron	5 studies	45% ± 31%	Explore
granule cell	4 studies	75% ± 25%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 15%	Explore
OFF-bipolar cell	4 studies	57% ± 31%	Explore
ON-bipolar cell	4 studies	60% ± 28%	Explore
amacrine cell	4 studies	41% ± 23%	Explore
astrocyte	4 studies	42% ± 27%	Explore
GABAergic interneuron	3 studies	65% ± 7%	Explore
Purkinje cell	3 studies	58% ± 30%	Explore
macrophage	3 studies	23% ± 6%	Explore
GABAergic amacrine cell	3 studies	43% ± 19%	Explore
glycinergic amacrine cell	3 studies	52% ± 26%	Explore
rod bipolar cell	3 studies	75% ± 31%	Explore
adipocyte	3 studies	47% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	50% ± 25%	Explore
heart	6 studies	45% ± 23%	Explore
eye	4 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	56%	1223.93	136 / 245	74%	3.38	372 / 502
brain	80%	4696.70	2116 / 2642	41%	2.32	288 / 705
thymus	86%	2228.20	562 / 653	30%	1.01	179 / 605
lung	89%	1882.91	512 / 578	26%	0.82	300 / 1155
pancreas	79%	1253.05	258 / 328	30%	0.71	54 / 178
ovary	83%	1881.54	150 / 180	23%	0.60	101 / 430
blood vessel	99%	6378.19	1326 / 1335	0%	0	0 / 0
heart	99%	58674.50	852 / 861	0%	0	0 / 0
esophagus	62%	3209.00	902 / 1445	31%	1.31	57 / 183
stomach	41%	1201.92	148 / 359	31%	1.03	89 / 286
intestine	51%	1191.27	491 / 966	20%	0.59	107 / 527
bladder	52%	1032.76	11 / 21	15%	0.36	74 / 504
adrenal gland	2%	25.53	5 / 258	54%	2.97	125 / 230
uterus	27%	378.31	46 / 170	15%	0.51	67 / 459
spleen	31%	429.29	75 / 241	0%	0	0 / 0
breast	22%	512.68	100 / 459	9%	0.35	103 / 1118
skin	2%	33.69	40 / 1809	22%	1.04	103 / 472
adipose	21%	397.89	257 / 1204	0%	0	0 / 0
kidney	0%	0	0 / 89	14%	0.44	127 / 901
lymph node	0%	0	0 / 0	10%	0.58	3 / 29
liver	0%	0	0 / 226	8%	0.34	31 / 406
eye	0%	0	0 / 0	1%	0.03	1 / 80
muscle	1%	12.74	8 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0098907	Biological process	regulation of SA node cell action potential
GO_0098910	Biological process	regulation of atrial cardiac muscle cell action potential
GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0006941	Biological process	striated muscle contraction
GO_0035994	Biological process	response to muscle stretch
GO_0086029	Biological process	Purkinje myocyte to ventricular cardiac muscle cell signaling
GO_0010882	Biological process	regulation of cardiac muscle contraction by calcium ion signaling
GO_0019722	Biological process	calcium-mediated signaling
GO_0070296	Biological process	sarcoplasmic reticulum calcium ion transport
GO_0086064	Biological process	cell communication by electrical coupling involved in cardiac conduction
GO_0098904	Biological process	regulation of AV node cell action potential
GO_0086005	Biological process	ventricular cardiac muscle cell action potential
GO_0071872	Biological process	cellular response to epinephrine stimulus
GO_0002027	Biological process	regulation of heart rate
GO_0003300	Biological process	cardiac muscle hypertrophy
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0060048	Biological process	cardiac muscle contraction
GO_0051649	Biological process	establishment of localization in cell
GO_0014850	Biological process	response to muscle activity
GO_0010881	Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0097050	Biological process	type B pancreatic cell apoptotic process
GO_0051775	Biological process	response to redox state
GO_0003220	Biological process	left ventricular cardiac muscle tissue morphogenesis
GO_0051284	Biological process	positive regulation of sequestering of calcium ion
GO_0001666	Biological process	response to hypoxia
GO_0071313	Biological process	cellular response to caffeine
GO_0060402	Biological process	calcium ion transport into cytosol
GO_0098911	Biological process	regulation of ventricular cardiac muscle cell action potential
GO_0098735	Biological process	positive regulation of the force of heart contraction
GO_0014808	Biological process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0031000	Biological process	response to caffeine
GO_0055117	Biological process	regulation of cardiac muscle contraction
GO_0006816	Biological process	calcium ion transport
GO_0072599	Biological process	establishment of protein localization to endoplasmic reticulum
GO_0010460	Biological process	positive regulation of heart rate
GO_0005513	Biological process	detection of calcium ion
GO_0003143	Biological process	embryonic heart tube morphogenesis
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0032991	Cellular component	protein-containing complex
GO_0042383	Cellular component	sarcolemma
GO_0014701	Cellular component	junctional sarcoplasmic reticulum membrane
GO_0034704	Cellular component	calcium channel complex
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0048763	Molecular function	calcium-induced calcium release activity
GO_0019899	Molecular function	enzyme binding
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0042802	Molecular function	identical protein binding
GO_0043924	Molecular function	suramin binding
GO_0034236	Molecular function	protein kinase A catalytic subunit binding
GO_0005219	Molecular function	ryanodine-sensitive calcium-release channel activity
GO_0015278	Molecular function	intracellularly gated calcium channel activity
GO_0005516	Molecular function	calmodulin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0005262	Molecular function	calcium channel activity

IV. Literature review

[source]

Gene name	RYR2
Protein name	Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) Ryanodine receptor 2 Alternative protein RYR2
Synonyms
Description	FUNCTION: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. .
Accessions	ENST00000659194.3 A0A590UJZ8 ENST00000366574.7 [Q92736-1] ENST00000609119.2 L8E9M2 Q92736 A0A590UJF6 ENST00000660292.2 A0A590UKB7 ENST00000661330.1 A0A590UK06

RYR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review