I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 3 studies | 30% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal cone cell | 3 studies | 30% ± 7% |
Insufficient scRNA-seq data for expression of NPPC at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 91% | 129.53 | 2399 / 2642 | 52% | 2.18 | 366 / 705 |
| prostate | 81% | 100.79 | 199 / 245 | 51% | 5.73 | 256 / 502 |
| esophagus | 70% | 64.50 | 1010 / 1445 | 33% | 6.55 | 60 / 183 |
| breast | 41% | 27.88 | 186 / 459 | 41% | 3.13 | 461 / 1118 |
| heart | 81% | 84.24 | 697 / 861 | 0% | 0 | 0 / 0 |
| thymus | 32% | 17.05 | 211 / 653 | 46% | 4.53 | 281 / 605 |
| ovary | 46% | 49.03 | 82 / 180 | 33% | 1.20 | 142 / 430 |
| uterus | 36% | 38.46 | 61 / 170 | 33% | 4.67 | 150 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 23.92 | 30 / 45 |
| intestine | 56% | 87.71 | 542 / 966 | 8% | 0.38 | 42 / 527 |
| skin | 19% | 10.09 | 341 / 1809 | 35% | 5.23 | 163 / 472 |
| stomach | 37% | 81.00 | 132 / 359 | 15% | 0.65 | 44 / 286 |
| bladder | 24% | 5.67 | 5 / 21 | 22% | 2.54 | 111 / 504 |
| lung | 2% | 0.74 | 12 / 578 | 34% | 9.14 | 395 / 1155 |
| adrenal gland | 2% | 0.36 | 4 / 258 | 32% | 30.46 | 74 / 230 |
| kidney | 8% | 3.65 | 7 / 89 | 21% | 1.45 | 191 / 901 |
| pancreas | 2% | 0.34 | 5 / 328 | 22% | 1.44 | 40 / 178 |
| muscle | 20% | 7.56 | 157 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 1.41 | 5 / 29 |
| adipose | 14% | 6.81 | 167 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 9% | 4.82 | 115 / 1335 | 0% | 0 | 0 / 0 |
| liver | 1% | 0.23 | 2 / 226 | 6% | 0.25 | 25 / 406 |
| peripheral blood | 3% | 1.24 | 32 / 929 | 0% | 0 | 0 / 0 |
| spleen | 3% | 1.90 | 8 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051447 | Biological process | negative regulation of meiotic cell cycle |
| GO_0019934 | Biological process | cGMP-mediated signaling |
| GO_0001525 | Biological process | angiogenesis |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0002931 | Biological process | response to ischemia |
| GO_0006182 | Biological process | cGMP biosynthetic process |
| GO_0009791 | Biological process | post-embryonic development |
| GO_0001549 | Biological process | cumulus cell differentiation |
| GO_0048678 | Biological process | response to axon injury |
| GO_0032966 | Biological process | negative regulation of collagen biosynthetic process |
| GO_0003419 | Biological process | growth plate cartilage chondrocyte proliferation |
| GO_1900194 | Biological process | negative regulation of oocyte maturation |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0040014 | Biological process | regulation of multicellular organism growth |
| GO_0045471 | Biological process | response to ethanol |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0097746 | Biological process | blood vessel diameter maintenance |
| GO_0048660 | Biological process | regulation of smooth muscle cell proliferation |
| GO_0071965 | Biological process | multicellular organismal locomotion |
| GO_0007168 | Biological process | receptor guanylyl cyclase signaling pathway |
| GO_0061939 | Biological process | c-di-GMP signaling |
| GO_0006457 | Biological process | protein folding |
| GO_0003418 | Biological process | growth plate cartilage chondrocyte differentiation |
| GO_0035483 | Biological process | gastric emptying |
| GO_0051276 | Biological process | chromosome organization |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1904588 | Biological process | cellular response to glycoprotein |
| GO_0090649 | Biological process | response to oxygen-glucose deprivation |
| GO_0001503 | Biological process | ossification |
| GO_0010753 | Biological process | positive regulation of cGMP-mediated signaling |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_2000279 | Biological process | negative regulation of DNA biosynthetic process |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_1903537 | Biological process | meiotic cell cycle process involved in oocyte maturation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0030141 | Cellular component | secretory granule |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0051427 | Molecular function | hormone receptor binding |
| Gene name | NPPC |
| Protein name | C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53] C-type natriuretic peptide |
| Synonyms | CNP2 |
| Description | FUNCTION: [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic . Acts by specifically binding and stimulating NPR2 to produce cGMP . Binds the clearance receptor NPR3 . . |
| Accessions | P23582 ENST00000409852.2 ENST00000295440.2 E5LCN7 |
