KCNMA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006813Biological processpotassium ion transport
GO_0042391Biological processregulation of membrane potential
GO_0034465Biological processresponse to carbon monoxide
GO_0060073Biological processmicturition
GO_0006970Biological processresponse to osmotic stress
GO_0071805Biological processpotassium ion transmembrane transport
GO_0001666Biological processresponse to hypoxia
GO_0042311Biological processvasodilation
GO_0030007Biological processintracellular potassium ion homeostasis
GO_0043065Biological processpositive regulation of apoptotic process
GO_0051592Biological processresponse to calcium ion
GO_0045794Biological processnegative regulation of cell volume
GO_0060083Biological processsmooth muscle contraction involved in micturition
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005901Cellular componentcaveola
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0015269Molecular functioncalcium-activated potassium channel activity
GO_0060072Molecular functionlarge conductance calcium-activated potassium channel activity
GO_0003779Molecular functionactin binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNMA1
Protein namePotassium calcium-activated channel subfamily M alpha 1
Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (Slo-alpha) (Slo1) (Slowpoke homolog)
Calcium-activated potassium channel subunit alpha-1 (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (Slo-alpha) (Slo1)
BK channel (Slowpoke homolog)
SynonymsSLO
KCNMA
DescriptionFUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) . It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). .

AccessionsENST00000639498.1
A0A1W2PQ93
ENST00000638203.1
ENST00000638606.1
ENST00000639090.1
A0A1W2PRV4
J3KQ16
ENST00000480683.2 [Q12791-6]
ENST00000639344.1
ENST00000626620.3 [Q12791-2]
A0A1W2PRF1
ENST00000640626.1
ENST00000638351.1
ENST00000604624.6
A0A1W2PQ53
A0A1W2PQK5
A0A1W2PR56
A0A0A0MRR0
A0A1W2PNW6
ENST00000640834.1
ENST00000354353.9
Q5SVJ9
ENST00000640353.1
ENST00000372440.6
ENST00000639591.1
A0A1W2PP26
A0A1W2PRG5
ENST00000457953.6
A0A1W2PNX9
A0A1W2PNG1
ENST00000638754.1
A0A0A0MSE6
ENST00000484343.2
ENST00000639995.1
A0A1W2PPQ3
ENST00000639205.1
A0A1W2PP94
ENST00000638759.1 [Q12791-3]
ENST00000639486.1
H0Y379
ENST00000404857.6
A0A1W2PSA7
A0A1W2PP06
A0A1W2PQA0
A0A1W2PR62
D5MRH1
ENST00000640523.1
ENST00000638514.1
ENST00000638848.1
A0A1W2PP37
Q5SVK0
A0A1W2PPH9
B7ZMF5
ENST00000638283.1
A0A9L9PXP1
A0A087WZL8
ENST00000638575.1 [Q12791-7]
ENST00000638506.1
A0A1W2PRA7
ENST00000639968.1
A0A1W2PRE5
A0A1W2PNY8
A0A1W2PQZ4
A0A1W2PRJ1
ENST00000404771.8
H0Y406
ENST00000639120.1
ENST00000640182.1
ENST00000638895.1
ENST00000639823.1
ENST00000640934.1
Q5SVJ7
ENST00000372437.6
Q5SVK5
ENST00000637862.2
ENST00000372408.7
A0A1W2PNH9
A0A9L9PYL6
ENST00000372443.6
A0A1B0GWD4
ENST00000372403.9
ENST00000640773.1
A0A1W2PNN5
A0A1W2PPZ1
A0A1W2PNN6
A0A1W2PPY5
A0A1W2PRT6
ENST00000481070.1
ENST00000640969.1 [Q12791-4]
ENST00000640029.1
ENST00000639483.1
ENST00000640807.1
Q12791
ENST00000640605.1
A0A1W2PPT7
S4R2X4
A0A1W2PNY7
A0A1W2PP76
ENST00000639691.1
A0A1W2PQ61
ENST00000639370.1
A0A1W2PQJ9
ENST00000640093.1
A0A1W2PRC3
S4R453
ENST00000639730.1
ENST00000406533.7
A0A1W2PPS2
ENST00000639489.1
ENST00000638306.1
ENST00000638751.1
ENST00000638531.1
Q5SVJ8
ENST00000640632.1
A0A1W2PPX7
ENST00000638249.1
ENST00000639406.1
ENST00000639716.1
ENST00000707138.1
ENST00000638252.1
A0A1W2PS97
ENST00000450795.6
A0A0A0MRC3
A0A1W2PNY9
A0A1W2PRB0
ENST00000707137.1
A0A1W2PQZ8
ENST00000618048.2
ENST00000372421.10
A0A1W2PQU4
ENST00000640386.1
ENST00000434208.6 [Q12791-4]
A0A1W2PQR1
ENST00000475352.1
ENST00000639601.1
A0A1W2PQ39
A0A1W2PS54
A0A1W2PSD3
ENST00000639544.1
ENST00000639913.1
H0Y382
A0A1W2PRX6
ENST00000640141.1
ENST00000638223.1
ENST00000638991.1
A0A1W2PRN5
A0A1W2PNQ3
ENST00000286627.10 [Q12791-5]
ENST00000286628.14 [Q12791-1]