Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 22 studies | 36% ± 17% | |
astrocyte | 20 studies | 58% ± 23% | |
oligodendrocyte precursor cell | 15 studies | 66% ± 20% | |
microglial cell | 15 studies | 51% ± 16% | |
smooth muscle cell | 15 studies | 34% ± 15% | |
GABAergic neuron | 11 studies | 64% ± 27% | |
glutamatergic neuron | 11 studies | 79% ± 20% | |
myeloid cell | 9 studies | 29% ± 16% | |
retinal ganglion cell | 7 studies | 51% ± 24% | |
neuron | 6 studies | 41% ± 17% | |
amacrine cell | 6 studies | 43% ± 27% | |
interneuron | 6 studies | 66% ± 25% | |
mast cell | 6 studies | 41% ± 15% | |
endothelial cell | 5 studies | 43% ± 22% | |
retinal bipolar neuron | 5 studies | 75% ± 17% | |
ON-bipolar cell | 5 studies | 63% ± 32% | |
pancreatic A cell | 4 studies | 45% ± 15% | |
Mueller cell | 4 studies | 36% ± 11% | |
OFF-bipolar cell | 4 studies | 68% ± 19% | |
epithelial cell | 4 studies | 47% ± 21% | |
basal cell | 4 studies | 38% ± 24% | |
goblet cell | 4 studies | 44% ± 22% | |
alveolar macrophage | 4 studies | 49% ± 21% | |
monocyte | 4 studies | 24% ± 8% | |
oligodendrocyte | 4 studies | 35% ± 25% | |
ionocyte | 3 studies | 40% ± 7% | |
pancreatic D cell | 3 studies | 39% ± 15% | |
type B pancreatic cell | 3 studies | 50% ± 23% | |
GABAergic interneuron | 3 studies | 70% ± 17% | |
GABAergic amacrine cell | 3 studies | 50% ± 12% | |
glycinergic amacrine cell | 3 studies | 49% ± 7% | |
rod bipolar cell | 3 studies | 86% ± 9% | |
hepatocyte | 3 studies | 40% ± 21% | |
ependymal cell | 3 studies | 73% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 89% | 5554.02 | 2346 / 2642 | 97% | 4.88 | 683 / 705 |
prostate | 91% | 6581.48 | 222 / 245 | 94% | 5.24 | 472 / 502 |
breast | 60% | 1993.58 | 275 / 459 | 74% | 3.67 | 823 / 1118 |
uterus | 99% | 20728.11 | 168 / 170 | 31% | 1.87 | 140 / 459 |
intestine | 88% | 14811.73 | 852 / 966 | 33% | 1.12 | 174 / 527 |
ovary | 49% | 1701.95 | 89 / 180 | 71% | 2.57 | 307 / 430 |
esophagus | 76% | 11839.89 | 1104 / 1445 | 38% | 2.21 | 70 / 183 |
bladder | 76% | 8882.86 | 16 / 21 | 28% | 0.77 | 141 / 504 |
blood vessel | 99% | 14353.24 | 1320 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 13% | 369.55 | 34 / 258 | 85% | 7.63 | 195 / 230 |
muscle | 97% | 6513.08 | 777 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 5.16 | 26 / 29 |
stomach | 47% | 6336.29 | 168 / 359 | 42% | 2.33 | 121 / 286 |
lung | 28% | 670.47 | 163 / 578 | 47% | 1.65 | 545 / 1155 |
kidney | 1% | 37.12 | 1 / 89 | 67% | 3.71 | 608 / 901 |
spleen | 68% | 1999.23 | 165 / 241 | 0% | 0 | 0 / 0 |
pancreas | 1% | 24.02 | 4 / 328 | 60% | 1.95 | 106 / 178 |
tonsil | 0% | 0 | 0 / 0 | 49% | 1.25 | 22 / 45 |
liver | 23% | 515.81 | 51 / 226 | 20% | 0.51 | 81 / 406 |
skin | 9% | 265.69 | 167 / 1809 | 27% | 0.92 | 128 / 472 |
adipose | 27% | 952.56 | 329 / 1204 | 0% | 0 | 0 / 0 |
thymus | 4% | 153.26 | 28 / 653 | 15% | 0.37 | 88 / 605 |
peripheral blood | 15% | 448.85 | 139 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 5% | 0.11 | 4 / 80 |
heart | 1% | 16.83 | 6 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006813 | Biological process | potassium ion transport |
GO_0042391 | Biological process | regulation of membrane potential |
GO_0034465 | Biological process | response to carbon monoxide |
GO_0060073 | Biological process | micturition |
GO_0006970 | Biological process | response to osmotic stress |
GO_0071805 | Biological process | potassium ion transmembrane transport |
GO_0001666 | Biological process | response to hypoxia |
GO_0042311 | Biological process | vasodilation |
GO_0030007 | Biological process | intracellular potassium ion homeostasis |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0051592 | Biological process | response to calcium ion |
GO_0045794 | Biological process | negative regulation of cell volume |
GO_0060083 | Biological process | smooth muscle contraction involved in micturition |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0045211 | Cellular component | postsynaptic membrane |
GO_0008076 | Cellular component | voltage-gated potassium channel complex |
GO_0005901 | Cellular component | caveola |
GO_0005249 | Molecular function | voltage-gated potassium channel activity |
GO_0015269 | Molecular function | calcium-activated potassium channel activity |
GO_0060072 | Molecular function | large conductance calcium-activated potassium channel activity |
GO_0003779 | Molecular function | actin binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | KCNMA1 |
Protein name | Potassium calcium-activated channel subfamily M alpha 1 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (Slo-alpha) (Slo1) (Slowpoke homolog) Calcium-activated potassium channel subunit alpha-1 (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (Slo-alpha) (Slo1) BK channel (Slowpoke homolog) |
Synonyms | SLO KCNMA |
Description | FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) . It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). . |
Accessions | ENST00000639498.1 A0A1W2PQ93 ENST00000638203.1 ENST00000638606.1 ENST00000639090.1 A0A1W2PRV4 J3KQ16 ENST00000480683.2 [Q12791-6] ENST00000639344.1 ENST00000626620.3 [Q12791-2] A0A1W2PRF1 ENST00000640626.1 ENST00000638351.1 ENST00000604624.6 A0A1W2PQ53 A0A1W2PQK5 A0A1W2PR56 A0A0A0MRR0 A0A1W2PNW6 ENST00000640834.1 ENST00000354353.9 Q5SVJ9 ENST00000640353.1 ENST00000372440.6 ENST00000639591.1 A0A1W2PP26 A0A1W2PRG5 ENST00000457953.6 A0A1W2PNX9 A0A1W2PNG1 ENST00000638754.1 A0A0A0MSE6 ENST00000484343.2 ENST00000639995.1 A0A1W2PPQ3 ENST00000639205.1 A0A1W2PP94 ENST00000638759.1 [Q12791-3] ENST00000639486.1 H0Y379 ENST00000404857.6 A0A1W2PSA7 A0A1W2PP06 A0A1W2PQA0 A0A1W2PR62 D5MRH1 ENST00000640523.1 ENST00000638514.1 ENST00000638848.1 A0A1W2PP37 Q5SVK0 A0A1W2PPH9 B7ZMF5 ENST00000638283.1 A0A9L9PXP1 A0A087WZL8 ENST00000638575.1 [Q12791-7] ENST00000638506.1 A0A1W2PRA7 ENST00000639968.1 A0A1W2PRE5 A0A1W2PNY8 A0A1W2PQZ4 A0A1W2PRJ1 ENST00000404771.8 H0Y406 ENST00000639120.1 ENST00000640182.1 ENST00000638895.1 ENST00000639823.1 ENST00000640934.1 Q5SVJ7 ENST00000372437.6 Q5SVK5 ENST00000637862.2 ENST00000372408.7 A0A1W2PNH9 A0A9L9PYL6 ENST00000372443.6 A0A1B0GWD4 ENST00000372403.9 ENST00000640773.1 A0A1W2PNN5 A0A1W2PPZ1 A0A1W2PNN6 A0A1W2PPY5 A0A1W2PRT6 ENST00000481070.1 ENST00000640969.1 [Q12791-4] ENST00000640029.1 ENST00000639483.1 ENST00000640807.1 Q12791 ENST00000640605.1 A0A1W2PPT7 S4R2X4 A0A1W2PNY7 A0A1W2PP76 ENST00000639691.1 A0A1W2PQ61 ENST00000639370.1 A0A1W2PQJ9 ENST00000640093.1 A0A1W2PRC3 S4R453 ENST00000639730.1 ENST00000406533.7 A0A1W2PPS2 ENST00000639489.1 ENST00000638306.1 ENST00000638751.1 ENST00000638531.1 Q5SVJ8 ENST00000640632.1 A0A1W2PPX7 ENST00000638249.1 ENST00000639406.1 ENST00000639716.1 ENST00000707138.1 ENST00000638252.1 A0A1W2PS97 ENST00000450795.6 A0A0A0MRC3 A0A1W2PNY9 A0A1W2PRB0 ENST00000707137.1 A0A1W2PQZ8 ENST00000618048.2 ENST00000372421.10 A0A1W2PQU4 ENST00000640386.1 ENST00000434208.6 [Q12791-4] A0A1W2PQR1 ENST00000475352.1 ENST00000639601.1 A0A1W2PQ39 A0A1W2PS54 A0A1W2PSD3 ENST00000639544.1 ENST00000639913.1 H0Y382 A0A1W2PRX6 ENST00000640141.1 ENST00000638223.1 ENST00000638991.1 A0A1W2PRN5 A0A1W2PNQ3 ENST00000286627.10 [Q12791-5] ENST00000286628.14 [Q12791-1] |