VEGFA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	18 studies	32% ± 13%	Explore
fibroblast	17 studies	32% ± 15%	Explore
astrocyte	15 studies	33% ± 14%	Explore
mast cell	14 studies	28% ± 15%	Explore
epithelial cell	13 studies	24% ± 11%	Explore
type I pneumocyte	12 studies	54% ± 15%	Explore
classical monocyte	10 studies	31% ± 12%	Explore
conventional dendritic cell	10 studies	24% ± 10%	Explore
adipocyte	10 studies	35% ± 15%	Explore
monocyte	8 studies	29% ± 12%	Explore
basal cell	8 studies	27% ± 8%	Explore
dendritic cell	7 studies	30% ± 12%	Explore
endothelial cell	7 studies	27% ± 18%	Explore
club cell	7 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	7 studies	26% ± 9%	Explore
abnormal cell	6 studies	30% ± 12%	Explore
myeloid cell	6 studies	26% ± 7%	Explore
pericyte	6 studies	35% ± 15%	Explore
connective tissue cell	6 studies	21% ± 5%	Explore
type II pneumocyte	5 studies	24% ± 6%	Explore
podocyte	5 studies	72% ± 18%	Explore
retinal pigment epithelial cell	5 studies	39% ± 13%	Explore
cardiac muscle cell	5 studies	22% ± 4%	Explore
endothelial cell of artery	5 studies	28% ± 8%	Explore
Mueller cell	5 studies	52% ± 23%	Explore
hepatocyte	5 studies	40% ± 18%	Explore
squamous epithelial cell	4 studies	30% ± 12%	Explore
monocyte-derived dendritic cell	4 studies	34% ± 13%	Explore
GABAergic neuron	4 studies	21% ± 5%	Explore
retinal ganglion cell	4 studies	30% ± 8%	Explore
ciliated cell	4 studies	22% ± 6%	Explore
retina horizontal cell	4 studies	50% ± 18%	Explore
smooth muscle cell	4 studies	24% ± 4%	Explore
respiratory goblet cell	4 studies	24% ± 6%	Explore
secretory cell	4 studies	23% ± 4%	Explore
brush cell	4 studies	22% ± 5%	Explore
myofibroblast cell	4 studies	32% ± 12%	Explore
mononuclear phagocyte	3 studies	30% ± 6%	Explore
neutrophil	3 studies	31% ± 5%	Explore
amacrine cell	3 studies	34% ± 23%	Explore
granulocyte	3 studies	27% ± 9%	Explore
glutamatergic neuron	3 studies	18% ± 5%	Explore
enterocyte	3 studies	18% ± 2%	Explore
adventitial cell	3 studies	19% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	27% ± 6%	Explore
intestine	5 studies	23% ± 9%	Explore
uterus	5 studies	23% ± 7%	Explore
brain	4 studies	18% ± 3%	Explore
eye	4 studies	26% ± 7%	Explore
liver	4 studies	27% ± 6%	Explore
pancreas	3 studies	40% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	14528.77	577 / 578	93%	58.47	1079 / 1155
pancreas	100%	6657.67	327 / 328	92%	50.51	163 / 178
uterus	99%	18510.93	169 / 170	87%	47.84	400 / 459
thymus	100%	47917.15	653 / 653	86%	77.80	522 / 605
bladder	90%	8436.43	19 / 21	92%	54.19	465 / 504
stomach	92%	7386.52	332 / 359	90%	39.75	258 / 286
esophagus	88%	6430.91	1276 / 1445	93%	48.73	171 / 183
intestine	86%	5514.21	828 / 966	95%	40.96	501 / 527
adrenal gland	97%	9787.90	251 / 258	83%	43.54	191 / 230
liver	100%	21426.08	226 / 226	78%	29.73	317 / 406
breast	99%	15513.80	455 / 459	79%	28.34	879 / 1118
prostate	98%	24312.54	240 / 245	79%	57.86	399 / 502
kidney	100%	17849.25	89 / 89	76%	240.11	684 / 901
ovary	63%	4047.57	114 / 180	92%	45.25	396 / 430
skin	90%	7777.34	1620 / 1809	40%	16.30	191 / 472
ureter	0%	0	0 / 0	100%	16.83	1 / 1
muscle	100%	16960.42	801 / 803	0%	0	0 / 0
spleen	100%	15068.41	240 / 241	0%	0	0 / 0
adipose	99%	19477.34	1196 / 1204	0%	0	0 / 0
heart	98%	18537.20	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	80%	31.22	36 / 45
brain	43%	1888.53	1126 / 2642	36%	36.08	257 / 705
blood vessel	67%	6974.11	898 / 1335	0%	0	0 / 0
peripheral blood	54%	4385.33	501 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	1.40	2 / 29
eye	0%	0	0 / 0	4%	0.98	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0038190	Biological process	VEGF-activated neuropilin signaling pathway
GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_1901532	Biological process	regulation of hematopoietic progenitor cell differentiation
GO_0030324	Biological process	lung development
GO_0048593	Biological process	camera-type eye morphogenesis
GO_0030225	Biological process	macrophage differentiation
GO_0001541	Biological process	ovarian follicle development
GO_0050918	Biological process	positive chemotaxis
GO_1903672	Biological process	positive regulation of sprouting angiogenesis
GO_0038084	Biological process	vascular endothelial growth factor signaling pathway
GO_1901492	Biological process	positive regulation of lymphangiogenesis
GO_0035767	Biological process	endothelial cell chemotaxis
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0042462	Biological process	eye photoreceptor cell development
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0001666	Biological process	response to hypoxia
GO_0043129	Biological process	surfactant homeostasis
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0060982	Biological process	coronary artery morphogenesis
GO_0036303	Biological process	lymph vessel morphogenesis
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0030224	Biological process	monocyte differentiation
GO_0048842	Biological process	positive regulation of axon extension involved in axon guidance
GO_0001525	Biological process	angiogenesis
GO_0060319	Biological process	primitive erythrocyte differentiation
GO_0051781	Biological process	positive regulation of cell division
GO_1904894	Biological process	positive regulation of receptor signaling pathway via STAT
GO_0003151	Biological process	outflow tract morphogenesis
GO_0001701	Biological process	in utero embryonic development
GO_0010629	Biological process	negative regulation of gene expression
GO_0030855	Biological process	epithelial cell differentiation
GO_0003169	Biological process	coronary vein morphogenesis
GO_0045766	Biological process	positive regulation of angiogenesis
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0010628	Biological process	positive regulation of gene expression
GO_1903141	Biological process	negative regulation of establishment of endothelial barrier
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0001822	Biological process	kidney development
GO_0035148	Biological process	tube formation
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0097533	Biological process	cellular stress response to acid chemical
GO_1900745	Biological process	positive regulation of p38MAPK cascade
GO_1900748	Biological process	positive regulation of vascular endothelial growth factor signaling pathway
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_2000048	Biological process	negative regulation of cell-cell adhesion mediated by cadherin
GO_0007399	Biological process	nervous system development
GO_0003007	Biological process	heart morphogenesis
GO_0007405	Biological process	neuroblast proliferation
GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010749	Biological process	regulation of nitric oxide mediated signal transduction
GO_0060754	Biological process	positive regulation of mast cell chemotaxis
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_1901165	Biological process	positive regulation of trophoblast cell migration
GO_0055013	Biological process	cardiac muscle cell development
GO_1905604	Biological process	negative regulation of blood-brain barrier permeability
GO_0001570	Biological process	vasculogenesis
GO_0001946	Biological process	lymphangiogenesis
GO_0060749	Biological process	mammary gland alveolus development
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_1903392	Biological process	negative regulation of adherens junction organization
GO_0002040	Biological process	sprouting angiogenesis
GO_0002070	Biological process	epithelial cell maturation
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_2001028	Biological process	positive regulation of endothelial cell chemotaxis
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0090190	Biological process	positive regulation of branching involved in ureteric bud morphogenesis
GO_0090037	Biological process	positive regulation of protein kinase C signaling
GO_0048010	Biological process	vascular endothelial growth factor receptor signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0031290	Biological process	retinal ganglion cell axon guidance
GO_0042311	Biological process	vasodilation
GO_0050930	Biological process	induction of positive chemotaxis
GO_0048469	Biological process	cell maturation
GO_1903589	Biological process	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0031077	Biological process	post-embryonic camera-type eye development
GO_0071456	Biological process	cellular response to hypoxia
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0060346	Biological process	bone trabecula formation
GO_0007498	Biological process	mesoderm development
GO_0048844	Biological process	artery morphogenesis
GO_0002042	Biological process	cell migration involved in sprouting angiogenesis
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0038091	Biological process	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0038033	Biological process	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO_0002092	Biological process	positive regulation of receptor internalization
GO_0060426	Biological process	lung vasculature development
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0097475	Biological process	motor neuron migration
GO_0071679	Biological process	commissural neuron axon guidance
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0010719	Biological process	negative regulation of epithelial to mesenchymal transition
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0001935	Biological process	endothelial cell proliferation
GO_0060948	Biological process	cardiac vascular smooth muscle cell development
GO_0006915	Biological process	apoptotic process
GO_0036324	Biological process	vascular endothelial growth factor receptor-2 signaling pathway
GO_0008360	Biological process	regulation of cell shape
GO_0061042	Biological process	vascular wound healing
GO_0007595	Biological process	lactation
GO_0098609	Biological process	cell-cell adhesion
GO_0043117	Biological process	positive regulation of vascular permeability
GO_1990150	Cellular component	VEGF-A complex
GO_0009986	Cellular component	cell surface
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0005912	Cellular component	adherens junction
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005615	Cellular component	extracellular space
GO_0016020	Cellular component	membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0031012	Cellular component	extracellular matrix
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0030141	Cellular component	secretory granule
GO_0048018	Molecular function	receptor ligand activity
GO_0042802	Molecular function	identical protein binding
GO_0042056	Molecular function	chemoattractant activity
GO_0005125	Molecular function	cytokine activity
GO_0008201	Molecular function	heparin binding
GO_0001968	Molecular function	fibronectin binding
GO_0043184	Molecular function	vascular endothelial growth factor receptor 2 binding
GO_0050840	Molecular function	extracellular matrix binding
GO_0030297	Molecular function	transmembrane receptor protein tyrosine kinase activator activity
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005161	Molecular function	platelet-derived growth factor receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0005172	Molecular function	vascular endothelial growth factor receptor binding
GO_0043183	Molecular function	vascular endothelial growth factor receptor 1 binding

IV. Literature review

[source]

Gene name	VEGFA
Protein name	Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA] VEGFA protein Vascular endothelial growth factor A Vascular permeability factor
Synonyms	VEGF
Description	FUNCTION: [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A . Involved in protecting cells from hypoxia-mediated cell death (By similarity). .; FUNCTION: [VEGFA]: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor . .; FUNCTION: [Isoform VEGF165B]: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. .
Accessions	ENST00000672860.3 [P15692-13] A2A2V4 ENST00000672860 H0YBZ0 ENST00000417285 ENST00000520948.5 [P15692-2] ENST00000520265.1 ENST00000372055.9 [P15692-14] ENST00000518824.5 [P15692-8] A0A0A0MSH5 P15692 A0A0A0MSH7 ENST00000230480.10 ENST00000523125.5 [P15692-5] ENST00000372055 A0A5F9ZH41 ENST00000324450 ENST00000519767.5 ENST00000413642.8 [P15692-16] ENST00000413642 A0A0A0MR43 ENST00000425836.9 ENST00000372064 Q96FD9 ENST00000523950.5 [P15692-4] ENST00000372064.9 [P15692-12] A0A0A0MSI7 H3BLW8 A0A0A0MRQ4 J3KPA4 H0YBI8 ENST00000523873.5 [P15692-1] ENST00000372077.8 [P15692-9] ENST00000482630.7 [P15692-15] ENST00000482630 ENST00000457104.6 [P15692-10] ENST00000518689.5 [P15692-3] ENST00000372067 ENST00000417285.7 [P15692-17] ENST00000372067.8 [P15692-11] A0A0A0MTB2 ENST00000324450.11 [P15692-18]

VEGFA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review