KCNA5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNA5 at tissue level.

III. Associated gene sets

GO_0042542Biological processresponse to hydrogen peroxide
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0050796Biological processregulation of insulin secretion
GO_0042391Biological processregulation of membrane potential
GO_0007219Biological processNotch signaling pathway
GO_0019229Biological processregulation of vasoconstriction
GO_0098914Biological processmembrane repolarization during atrial cardiac muscle cell action potential
GO_0086052Biological processmembrane repolarization during SA node cell action potential
GO_0043266Biological processregulation of potassium ion transport
GO_0055075Biological processpotassium ion homeostasis
GO_0086014Biological processatrial cardiac muscle cell action potential
GO_2000288Biological processpositive regulation of myoblast proliferation
GO_0071805Biological processpotassium ion transmembrane transport
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0060081Biological processmembrane hyperpolarization
GO_0055093Biological processresponse to hyperoxia
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0001666Biological processresponse to hypoxia
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0009612Biological processresponse to mechanical stimulus
GO_0001508Biological processaction potential
GO_0086050Biological processmembrane repolarization during bundle of His cell action potential
GO_0051481Biological processnegative regulation of cytosolic calcium ion concentration
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0030018Cellular componentZ disc
GO_0034705Cellular componentpotassium channel complex
GO_0005794Cellular componentGolgi apparatus
GO_0009986Cellular componentcell surface
GO_0046691Cellular componentintracellular canaliculus
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005901Cellular componentcaveola
GO_0014704Cellular componentintercalated disc
GO_0086090Molecular functionvoltage-gated potassium channel activity involved in SA node cell action potential repolarization
GO_0015271Molecular functionoutward rectifier potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0086089Molecular functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO_0019901Molecular functionprotein kinase binding
GO_0005102Molecular functionsignaling receptor binding
GO_0051393Molecular functionalpha-actinin binding
GO_0097110Molecular functionscaffold protein binding
GO_0086087Molecular functionvoltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNA5
Protein namePotassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel . Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation . Homotetrameric channels display rapid activation and slow inactivation . May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation . .

AccessionsP22460
ENST00000252321.5 [P22460-1]