Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 27 studies | 37% ± 16% | |
fibroblast | 23 studies | 34% ± 13% | |
pericyte | 14 studies | 27% ± 9% | |
connective tissue cell | 11 studies | 36% ± 8% | |
vein endothelial cell | 11 studies | 37% ± 12% | |
endothelial cell of vascular tree | 10 studies | 32% ± 12% | |
mast cell | 8 studies | 22% ± 7% | |
capillary endothelial cell | 7 studies | 40% ± 13% | |
basal cell | 7 studies | 27% ± 9% | |
oligodendrocyte precursor cell | 6 studies | 28% ± 7% | |
myofibroblast cell | 5 studies | 37% ± 21% | |
epithelial cell | 5 studies | 36% ± 15% | |
squamous epithelial cell | 4 studies | 20% ± 3% | |
glomerular endothelial cell | 4 studies | 97% ± 3% | |
smooth muscle cell | 4 studies | 27% ± 5% | |
adventitial cell | 4 studies | 29% ± 12% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 49% ± 8% | |
secretory cell | 4 studies | 29% ± 14% | |
hillock cell | 3 studies | 34% ± 13% | |
endothelial cell of artery | 3 studies | 20% ± 4% | |
mesothelial cell | 3 studies | 48% ± 4% | |
microglial cell | 3 studies | 20% ± 1% | |
glial cell | 3 studies | 33% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 10749.57 | 21 / 21 | 82% | 101.01 | 411 / 504 |
breast | 98% | 4787.87 | 449 / 459 | 83% | 82.02 | 930 / 1118 |
stomach | 99% | 4166.96 | 356 / 359 | 79% | 23.85 | 226 / 286 |
lung | 99% | 5142.64 | 574 / 578 | 77% | 66.21 | 886 / 1155 |
intestine | 100% | 6304.26 | 965 / 966 | 75% | 29.16 | 393 / 527 |
esophagus | 94% | 3989.58 | 1354 / 1445 | 80% | 46.22 | 146 / 183 |
uterus | 99% | 5213.20 | 169 / 170 | 73% | 82.95 | 335 / 459 |
prostate | 100% | 7039.20 | 245 / 245 | 69% | 41.44 | 348 / 502 |
ovary | 92% | 2701.34 | 166 / 180 | 75% | 44.33 | 324 / 430 |
adrenal gland | 100% | 5246.11 | 258 / 258 | 64% | 48.88 | 148 / 230 |
thymus | 99% | 4289.41 | 645 / 653 | 53% | 17.25 | 321 / 605 |
skin | 52% | 2127.58 | 938 / 1809 | 95% | 149.61 | 447 / 472 |
kidney | 100% | 9548.60 | 89 / 89 | 44% | 15.17 | 394 / 901 |
pancreas | 30% | 375.68 | 100 / 328 | 93% | 209.84 | 166 / 178 |
brain | 76% | 1234.88 | 2020 / 2642 | 36% | 23.31 | 257 / 705 |
ureter | 0% | 0 | 0 / 0 | 100% | 21.55 | 1 / 1 |
adipose | 96% | 4815.96 | 1155 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 88% | 3388.66 | 1172 / 1335 | 0% | 0 | 0 / 0 |
heart | 69% | 1150.50 | 590 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 67% | 45.23 | 30 / 45 |
eye | 0% | 0 | 0 / 0 | 50% | 12.13 | 40 / 80 |
muscle | 31% | 367.72 | 246 / 803 | 0% | 0 | 0 / 0 |
liver | 11% | 125.97 | 24 / 226 | 12% | 4.45 | 49 / 406 |
spleen | 4% | 63.81 | 10 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 14.14 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0014909 | Biological process | smooth muscle cell migration |
GO_0051918 | Biological process | negative regulation of fibrinolysis |
GO_0010757 | Biological process | negative regulation of plasminogen activation |
GO_0007596 | Biological process | blood coagulation |
GO_0042730 | Biological process | fibrinolysis |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0045861 | Biological process | negative regulation of proteolysis |
GO_0036211 | Biological process | protein modification process |
GO_0001666 | Biological process | response to hypoxia |
GO_0006508 | Biological process | proteolysis |
GO_0060468 | Biological process | prevention of polyspermy |
GO_0099183 | Biological process | trans-synaptic signaling by BDNF, modulating synaptic transmission |
GO_0031639 | Biological process | plasminogen activation |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
GO_0070062 | Cellular component | extracellular exosome |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0097180 | Cellular component | serine protease inhibitor complex |
GO_0009986 | Cellular component | cell surface |
GO_0005737 | Cellular component | cytoplasm |
GO_0030141 | Cellular component | secretory granule |
GO_0045177 | Cellular component | apical part of cell |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0051219 | Molecular function | phosphoprotein binding |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | PLAT |
Protein name | Plasminogen activator, tissue type t-plasminogen activator (EC 3.4.21.68) Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] Plasminogen activator (EC 3.4.21.68) |
Synonyms | |
Description | FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). . |
Accessions | ENST00000429710.6 ENST00000519510.5 ENST00000521694.1 ENST00000520523.5 H0YBH9 E5RHG4 B4DN26 E5RGA1 ENST00000429089.6 [P00750-1] ENST00000678676.1 ENST00000679300.1 ENST00000352041.7 [P00750-3] A0A7I2V268 ENST00000220809.9 [P00750-1] ENST00000679151.1 [P00750-1] B4DNJ1 ENST00000678083.1 A0A7I2V6D6 P00750 ENST00000524009.5 E7ESF4 A0A7I2YQ93 B8ZX62 ENST00000521042.1 |