PLAT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014909Biological processsmooth muscle cell migration
GO_0051918Biological processnegative regulation of fibrinolysis
GO_0010757Biological processnegative regulation of plasminogen activation
GO_0007596Biological processblood coagulation
GO_0042730Biological processfibrinolysis
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0045861Biological processnegative regulation of proteolysis
GO_0036211Biological processprotein modification process
GO_0001666Biological processresponse to hypoxia
GO_0006508Biological processproteolysis
GO_0060468Biological processprevention of polyspermy
GO_0099183Biological processtrans-synaptic signaling by BDNF, modulating synaptic transmission
GO_0031639Biological processplasminogen activation
GO_0098978Cellular componentglutamatergic synapse
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0097180Cellular componentserine protease inhibitor complex
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0030141Cellular componentsecretory granule
GO_0045177Cellular componentapical part of cell
GO_0005102Molecular functionsignaling receptor binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePLAT
Protein namePlasminogen activator, tissue type
t-plasminogen activator (EC 3.4.21.68)
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
Plasminogen activator (EC 3.4.21.68)
Synonyms
DescriptionFUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). .

AccessionsENST00000429710.6
ENST00000519510.5
ENST00000521694.1
ENST00000520523.5
H0YBH9
E5RHG4
B4DN26
E5RGA1
ENST00000429089.6 [P00750-1]
ENST00000678676.1
ENST00000679300.1
ENST00000352041.7 [P00750-3]
A0A7I2V268
ENST00000220809.9 [P00750-1]
ENST00000679151.1 [P00750-1]
B4DNJ1
ENST00000678083.1
A0A7I2V6D6
P00750
ENST00000524009.5
E7ESF4
A0A7I2YQ93
B8ZX62
ENST00000521042.1