PKLR | OmnibusX

Name	Number of supported studies	Average coverage
erythrocyte	3 studies	36% ± 14%	Explore
erythroblast	3 studies	34% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PKLR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	3992.75	226 / 226	94%	121.47	380 / 406
kidney	97%	1226.10	86 / 89	69%	16.26	625 / 901
skin	62%	70.38	1121 / 1809	36%	7.63	169 / 472
intestine	49%	126.08	478 / 966	27%	2.01	142 / 527
brain	61%	44.23	1621 / 2642	0%	0.00	1 / 705
peripheral blood	43%	39.32	399 / 929	0%	0	0 / 0
stomach	3%	0.44	12 / 359	29%	2.92	83 / 286
spleen	30%	14.68	72 / 241	0%	0	0 / 0
lung	15%	3.03	89 / 578	2%	0.17	22 / 1155
esophagus	7%	1.39	97 / 1445	7%	0.69	12 / 183
bladder	0%	0	0 / 21	10%	0.88	49 / 504
adipose	7%	1.86	82 / 1204	0%	0	0 / 0
uterus	5%	0.66	8 / 170	2%	0.08	8 / 459
thymus	5%	0.81	34 / 653	0%	0	0 / 605
eye	0%	0	0 / 0	5%	0.13	4 / 80
prostate	5%	0.78	12 / 245	0%	0	0 / 502
breast	4%	0.68	20 / 459	0%	0.01	2 / 1118
adrenal gland	4%	0.64	11 / 258	0%	0	0 / 230
blood vessel	2%	0.39	32 / 1335	0%	0	0 / 0
pancreas	1%	0.15	3 / 328	1%	0.16	2 / 178
ovary	2%	0.30	3 / 180	0%	0	0 / 430
muscle	1%	0.19	8 / 803	0%	0	0 / 0
heart	1%	0.20	7 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007584	Biological process	response to nutrient
GO_0010038	Biological process	response to metal ion
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0009749	Biological process	response to glucose
GO_0006096	Biological process	glycolytic process
GO_0033198	Biological process	response to ATP
GO_0071872	Biological process	cellular response to epinephrine stimulus
GO_0051591	Biological process	response to cAMP
GO_0042866	Biological process	pyruvate biosynthetic process
GO_0001666	Biological process	response to hypoxia
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004743	Molecular function	pyruvate kinase activity
GO_0048029	Molecular function	monosaccharide binding
GO_0000287	Molecular function	magnesium ion binding
GO_0030955	Molecular function	potassium ion binding
GO_0005524	Molecular function	ATP binding
GO_0016301	Molecular function	kinase activity
GO_0005515	Molecular function	protein binding

Gene name	PKLR
Protein name	Pyruvate kinase PKLR Pyruvate kinase isoform 1 Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) pyruvate kinase (EC 2.7.1.40) Pyruvate kinase (EC 2.7.1.40)
Synonyms	PKL PK1
Description	FUNCTION: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. .
Accessions	ENST00000571194.5 [P30613-2] ENST00000434082.3 F8W6W2 A0A4D6DDP3 ENST00000573938.1 A0A4D6DDB2 A0A4D6DDG8 A0A977JB91 ENST00000392414.7 [P30613-2] ENST00000342741.6 [P30613-1] ENST00000572740.1 [P30613-1] A0A0G2JLC7 P30613

PKLR report