KCNJ11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNJ11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNJ11 at tissue level.

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0032355Biological processresponse to estradiol
GO_0071333Biological processcellular response to glucose stimulus
GO_0050796Biological processregulation of insulin secretion
GO_0042391Biological processregulation of membrane potential
GO_0002931Biological processresponse to ischemia
GO_0061762Biological processCAMKK-AMPK signaling cascade
GO_0008340Biological processdetermination of adult lifespan
GO_0033198Biological processresponse to ATP
GO_0046676Biological processnegative regulation of insulin secretion
GO_0098662Biological processinorganic cation transmembrane transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0001666Biological processresponse to hypoxia
GO_1904638Biological processresponse to resveratrol
GO_0003229Biological processventricular cardiac muscle tissue development
GO_0006915Biological processapoptotic process
GO_0071316Biological processcellular response to nicotine
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0001508Biological processaction potential
GO_0050877Biological processnervous system process
GO_0006006Biological processglucose metabolic process
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0001669Cellular componentacrosomal vesicle
GO_0008282Cellular componentinward rectifying potassium channel
GO_0005886Cellular componentplasma membrane
GO_0070852Cellular componentcell body fiber
GO_0043025Cellular componentneuronal cell body
GO_0005635Cellular componentnuclear envelope
GO_0042734Cellular componentpresynaptic membrane
GO_0030315Cellular componentT-tubule
GO_0030673Cellular componentaxolemma
GO_0005768Cellular componentendosome
GO_0014704Cellular componentintercalated disc
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0019829Molecular functionATPase-coupled monoatomic cation transmembrane transporter activity
GO_0031072Molecular functionheat shock protein binding
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0030955Molecular functionpotassium ion binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005524Molecular functionATP binding
GO_0030506Molecular functionankyrin binding
GO_0005515Molecular functionprotein binding
GO_0015272Molecular functionATP-activated inward rectifier potassium channel activity

IV. Literature review

[source]
Gene nameKCNJ11
Protein nameATP-sensitive inward rectifier potassium channel 11 (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
Mutant potassium inwardly-rectifying channel subfamily J member 11
Inwardly rectifing potassium channel subfamily J member 11 (Inwardly-rectifying potassium channel subfamily J member 11)
ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
Potassium inwardly rectifying channel subfamily J member 11
Synonyms
DescriptionFUNCTION: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. .

AccessionsC5IU89
A0A804HHV7
ENST00000682764.1 [Q14654-2]
D2K1F9
ENST00000528992.2
E9PPF1
ENST00000682350.1 [Q14654-2]
Q14654
ENST00000682764.1
C5IU90
H0YES9
ENST00000526912.1
A0A220SZY8
ENST00000682350.1
ENST00000339994.5 [Q14654-1]
ENST00000528731.1 [Q14654-2]