FCGR3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042116Biological processmacrophage activation
GO_0019722Biological processcalcium-mediated signaling
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0030101Biological processnatural killer cell activation
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0006955Biological processimmune response
GO_0001788Biological processantibody-dependent cellular cytotoxicity
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043320Biological processnatural killer cell degranulation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0038094Biological processFc-gamma receptor signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0033001Cellular componentFc-gamma receptor III complex
GO_0070062Cellular componentextracellular exosome
GO_0019772Molecular functionlow-affinity IgG receptor activity
GO_0140375Molecular functionimmune receptor activity
GO_0019770Molecular functionIgG receptor activity
GO_0019864Molecular functionIgG binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFCGR3A
Protein nameFc gamma receptor IIIa
CD16A
Low affinity immunoglobulin gamma Fc region receptor III-A
Fc of IgG low affinity IIIa receptor isoform 1
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
SynonymsIGFR3
CD16A
FCGR3
FCG3
DescriptionFUNCTION: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger . Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC . Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis . Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation . Costimulates NK cells and trigger lysis of target cells independently of IgG binding . Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells . Mediates enhanced ADCC in response to afucosylated IgGs . .; FUNCTION: (Microbial infection) Involved in Dengue virus pathogenesis via antibody-dependent enhancement (ADE) mechanism. Secondary infection with Dengue virus triggers elevated levels of afucosylated non-neutralizing IgG1s with reactivity to viral envelope/E protein. Viral antigen-IgG1 complexes bind with high affinity to FCGR3A, facilitating virus entry in myeloid cells and subsequent viral replication. .

AccessionsENST00000699493.1
A0A2H4Z8F3
A0A2H4Z8E5
P08637
ENST00000699395.1
ENST00000699400.1
A0A2H4Z8F0
ENST00000699401.1
ENST00000699397.1
ENST00000426740.8
A0A0S2Z3S7
ENST00000442336.2
A0A1W2PQB1
ENST00000699399.1
ENST00000436743.7
A0A2H4Z8E2
A0A2H4Z8F2
A0A8V8TNB3
A0A2H4Z8E3
A0A8V8TPL1
H0Y755
A0A8V8TNB8
C9JC71
ENST00000367967.8
ENST00000443193.6
ENST00000699396.1
ENST00000699398.1
A0A8V8TQ03