I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| extravillous trophoblast | 3 studies | 74% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| extravillous trophoblast | 3 studies | 74% ± 2% |
Insufficient scRNA-seq data for expression of HLA-G at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 92% | 116.19 | 82 / 89 | 91% | 49.39 | 817 / 901 |
| thymus | 93% | 108.90 | 610 / 653 | 84% | 29.45 | 509 / 605 |
| lung | 100% | 380.30 | 576 / 578 | 76% | 13.68 | 880 / 1155 |
| bladder | 90% | 68.43 | 19 / 21 | 77% | 11.29 | 386 / 504 |
| skin | 89% | 78.74 | 1608 / 1809 | 78% | 30.32 | 368 / 472 |
| intestine | 89% | 129.91 | 857 / 966 | 78% | 11.21 | 409 / 527 |
| pancreas | 76% | 57.59 | 248 / 328 | 90% | 15.94 | 161 / 178 |
| uterus | 91% | 89.14 | 154 / 170 | 74% | 8.50 | 339 / 459 |
| breast | 95% | 114.05 | 435 / 459 | 68% | 7.72 | 760 / 1118 |
| prostate | 92% | 79.51 | 225 / 245 | 64% | 4.51 | 321 / 502 |
| adrenal gland | 87% | 92.19 | 225 / 258 | 64% | 6.82 | 147 / 230 |
| stomach | 84% | 79.55 | 303 / 359 | 58% | 7.30 | 166 / 286 |
| liver | 59% | 41.61 | 133 / 226 | 68% | 5.64 | 276 / 406 |
| ovary | 78% | 53.44 | 140 / 180 | 25% | 2.55 | 108 / 430 |
| esophagus | 81% | 54.89 | 1164 / 1445 | 20% | 1.10 | 36 / 183 |
| peripheral blood | 99% | 567.93 | 919 / 929 | 0% | 0 | 0 / 0 |
| spleen | 99% | 335.65 | 238 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 17.01 | 28 / 29 |
| adipose | 93% | 112.03 | 1124 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 86% | 69.44 | 1144 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 12.35 | 38 / 45 |
| heart | 79% | 50.30 | 677 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 9.67 | 60 / 80 |
| brain | 26% | 12.51 | 696 / 2642 | 28% | 1.69 | 196 / 705 |
| muscle | 34% | 14.93 | 276 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002666 | Biological process | positive regulation of T cell tolerance induction |
| GO_2000774 | Biological process | positive regulation of cellular senescence |
| GO_0002476 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| GO_0002486 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0050777 | Biological process | negative regulation of immune response |
| GO_0070207 | Biological process | protein homotrimerization |
| GO_0001915 | Biological process | negative regulation of T cell mediated cytotoxicity |
| GO_0070317 | Biological process | negative regulation of G0 to G1 transition |
| GO_0002729 | Biological process | positive regulation of natural killer cell cytokine production |
| GO_0006968 | Biological process | cellular defense response |
| GO_0002767 | Biological process | immune response-inhibiting cell surface receptor signaling pathway |
| GO_2001199 | Biological process | negative regulation of dendritic cell differentiation |
| GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
| GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0006955 | Biological process | immune response |
| GO_0002645 | Biological process | positive regulation of tolerance induction |
| GO_0045953 | Biological process | negative regulation of natural killer cell mediated cytotoxicity |
| GO_0042270 | Biological process | protection from natural killer cell mediated cytotoxicity |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_0002451 | Biological process | peripheral B cell tolerance induction |
| GO_0060907 | Biological process | positive regulation of macrophage cytokine production |
| GO_0045591 | Biological process | positive regulation of regulatory T cell differentiation |
| GO_2000353 | Biological process | positive regulation of endothelial cell apoptotic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0031527 | Cellular component | filopodium membrane |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0098553 | Cellular component | lumenal side of endoplasmic reticulum membrane |
| GO_0033106 | Cellular component | cis-Golgi network membrane |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0042612 | Cellular component | MHC class I protein complex |
| GO_0012507 | Cellular component | ER to Golgi transport vesicle membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0042610 | Molecular function | CD8 receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042605 | Molecular function | peptide antigen binding |
| Gene name | HLA-G |
| Protein name | Mutant MHC class Ib antigen HLA-G histocompatibility antigen, class I, G, isoform CRA_a (MHC class I antigen) (MHC class Ib antigen) (Major histocompatibility complex, class I, G) HLA class I histocompatibility antigen, alpha chain G (HLA-G histocompatibility antigen, class I, G, isoform CRA_b) (Major histocompatibility complex, class I, G) HLA class I histocompatibility antigen, alpha chain G Major histocompatibility complex, class I, G HLA-G MHC class I antigen heavy chain a2 domain HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)] MHC class Ib antigen MHC lymphocyte antigen Class I histocompatibility antigen B2 microglobulin (HLA class I histocompatibility antigen, alpha chain G) MHC class I antigen (MHC class Ib antigen) MHC class I antigen heavy chain a1 domain HLA-G histocompatibility antigen, class I, G (HLA-G protein) (MHC class I antigen) (MHC class Ib antigen) (Major histocompatibility complex, class I, G) HLA-G protein Mutant MHC class I antigen Truncated MHC class I antigen MHC class I antigen HLA class I histocompatibility antigen, alpha chain G (MHC class I antigen) (MHC class Ib antigen) Lymphocyte antigen HLA-antigen HLA-G histocompatibility antigen, class I, G |
| Synonyms | RP3-377H14.2-001 HLAG hCG_1999524 HLA-G2.2 HLA-6.0 |
| Description | FUNCTION: [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface . In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins . Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance . Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy . Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling . Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance . May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells . Reprograms B cells toward an immune suppressive phenotype via LILRB1 . May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes . Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites . .; FUNCTION: [Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity . .; FUNCTION: [Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity . .; FUNCTION: [Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity . .; FUNCTION: [Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface . In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins . Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance . Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy . Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling . Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance . Reprograms B cells toward an immune suppressive phenotype via LILRB1 . .; FUNCTION: [Isoform 6]: Likely does not bind B2M and presents peptides. .; FUNCTION: [Isoform 7]: Likely does not bind B2M and presents peptides. . |
| Accessions | A0A0H4LVP8 A0A0H4LZ18 A0A0H4LU25 A0A890BW50 A0A0H4LX64 A0A0H4LZ73 O02924 A0A0H4LXB5 Q6B844 B5LFX8 Q6DL88 O19588 A0A0H4LX55 A0A0H4M9X8 A0A0H4LTY3 A0A0H4LTV2 A0A0H4LYU0 A0A0H4LZ47 A0A7I8HN19 A0A0H4M9V5 Q9MYA2 A0A0H4LX10 O19766 A0A0H4LTZ3 J3JRT1 J7H084 B5LFY0 A0A0H4LZ34 A0A0H4LVB9 ENST00000383623.8 [P17693-2] ENST00000434881.5 A0A0H4LVG5 ENST00000426863.6 B0L3Q0 Q9TP13 A0A0H4LYX8 A0A0H4LVG1 ENST00000457132.6 [P17693-3] A0A0H4LXC0 P17693 A0A0S2VHB8 A0A0H4MA78 A0A0H4LXG5 Q95HM6 A0A0H4MA49 A0A0H4LZ30 ENST00000550897.1 [P17693-1] A0A0H4LVI3 O02926 Q6DU08 A0A0H4LZ10 O19807 C0JSV2 A0A0G2JNX1 O19684 A0A0H4LX21 A0A0H4LXF2 A0A0H4LZ38 A0A0H4LZ43 A0A0H4LVT1 A0A0H4MA37 A0A0H4MAB3 A0A0H4M9Z1 A0A0H4LVC2 A0A0H4LVL9 A0A0H4LVT5 O02925 O78135 ENST00000376818.7 [P17693-2] Q5RJ85 A0A0H4LU54 Q6B849 Q9BCT7 Q9TP12 Q6UV35 ENST00000452577.6 [P17693-2] A0A0H4LU94 O19806 Q6B9Y3 A0A0H4LXD0 A0A0H4M9V1 A0A0H4LUB4 Q6B9Y6 A0A0H4LYZ0 R9WWD4 A0A0H4MA62 A0A0H4LVR3 A0A0H4LUA4 A0A0H4LTV9 B1P198 A0A0H4LU40 A0A0H4LU78 A0A6M3VZI4 A0A0H4LUA9 ENST00000615464.4 A0A0H4MAA2 A0A0H4MA87 ENST00000434907.6 [P17693-2] A0A0H4M9X7 A0A0H4LU84 A0A0H4LX77 A0A0H4MA90 Q9TP14 ENST00000360323.11 [P17693-1] A0A0H4LVL4 A0A0H4LX96 A0A0H4LWZ2 O78131 Q6DL89 Q6DL87 A0A291FAL5 ENST00000546545.2 [P17693-1] A0A0H4LVC9 ENST00000449127.6 [P17693-1] A0A0H4LU66 A0A2K9YCN0 Q6B850 R9WXB4 A0A0H4LU07 Q6B845 ENST00000422371.5 ENST00000469472.5 [P17693-2] A0A0H4LTX1 G0T3C4 A0A0H4LTU8 Q68YS2 A0A0H4MA72 A0A0H4MA56 A0A0H4LVE3 A0A0H4M9Y2 A0A0H4MA94 A0A0H4LTX5 A0A0H4LX25 Q6DL85 A0A0H4M9X9 A0A0H4M9W9 A0A3G2WH74 A0A0H4LTU3 A0A0H4LZA3 Q6B848 A0A0H4LXA0 A0A0H4LVK4 A0A0H4LYT4 A0A0H4LTY8 ENST00000428952.6 [P17693-1] O19809 A0A0H4LYT7 M9TK49 ENST00000466488.5 [P17693-2] A0A0H4LZ89 ENST00000434907.6 R9WYY4 A0A0H4LZ02 A0A3G2LZB3 A0A0H4LU49 C0JT28 ENST00000376815.3 [P17693-3] A0A0H4LTW7 Q8MH47 A0A0H4LZ98 A0A0H4LU10 A0A6M3VZ10 A0A0H4LXA6 A0A0H4LXG1 B5LFX9 Q68YS4 ENST00000547241.2 [P17693-1] A0A0H4LX60 Q6B9Y2 A0A6M3VZ79 A0A0H4MAB7 B7SFZ2 ENST00000486553.5 A0A1L2BLQ5 A0A0H4LXD4 A0A0H4MA15 O78133 A0A0H4MA11 A0A0H4LYX3 B7SFZ3 A0A0H4LX84 C7SJ32 Q6B846 Q68YR8 Q68YS0 A0A0H4MA67 A0A0H4LVC6 A0A0H4LXE3 E5DHS1 A0A0H4MAA7 A0A0H4LU89 A0A0H4LZ65 ENST00000618039.4 A0A0H4M9Y6 A0A0H4M9X4 Q6B9Y1 A0A0H4LU20 ENST00000618812.1 A0A0H4LX45 Q30182 A0A0H4M9Y3 B5LFY2 A0A0H4LYW9 ENST00000553052.2 [P17693-1] A0A0H4LZ82 O02927 ENST00000415687.6 [P17693-3] ENST00000469347.5 A0A0H4LX39 A0A0H4LX89 A0A0H4LTV6 O19808 Q8MGQ7 A0A0H4LVQ3 A0A0H4LVK0 A0A0H4LZ68 A0A0H4M9Y1 Q68YS3 A0A0H4LTT9 A0A0H4LU72 A0A0H4LVS7 O02929 A0A0H4LZ05 Q31611 A0A0H4LU02 A0A0H4M9W0 Q6DL86 Q6B9Y4 A0A0H4LVF7 ENST00000400665.5 A0A0H4LU34 A0A0H4LVD7 A0A0H4LZ25 B0L3P9 A5HSK0 Q7JFN0 ENST00000546634.1 [P17693-1] ENST00000430253.5 [P17693-2] A0A0H4LVQ9 A0A0H4LVJ5 O78136 ENST00000376828.6 Q6B9Y0 A0A0H4LVF0 A0A0H4LZ87 A0A0H4LX41 A0A0H4MA26 A0A0H4LWZ5 C0JT30 B0L3P8 A0A0H4LYU9 A0A0H4LVH3 O78132 A0A0H4M9Y0 O19805 Q9TP11 A0A0H4LTX9 A0A0H4LVR9 ENST00000376818.7 Q95391 A0A0H4LVP5 C0JSV3 A0A0H4LXE8 A0A0H4LVF3 A6YB83 Q6B9Y5 A0A0H4LZ77 O02923 ENST00000478519.5 [P17693-2] ENST00000615098.4 A0A0H4LYV4 Q68YR9 A0A0H4LVM3 Q6B847 A0A0H4M9U7 A0A0H4LZ60 A0A0H4MA20 Q9TP10 A0A1L2BLQ6 A0A0H4LVI8 ENST00000452715.6 [P17693-2] ENST00000466488.5 Q6DU14 A0A0H4LVE7 ENST00000448306.6 [P17693-3] A0A0H4M9U3 A0A0H4LX80 Q68YS1 A0A0H4LVP1 Q8WLS1 ENST00000486553.5 [P17693-2] A0A0H4LZ50 A0A0H4LVH8 ENST00000383621.8 [P17693-1] A0A1V0E3X1 A0A0H4LUB8 A0A0H4LU30 ENST00000450984.5 A0A0H4LTZ9 A0A0H4LVJ1 Q30213 ENST00000400682.5 A0A0H4LX05 A0A0H4LX73 A0A0H4LU14 ENST00000429890.6 [P17693-3] ENST00000426863.6 [P17693-2] A0A0H4LVS3 A0A0G2JPQ3 A0A0H4LUC7 A0A0H4LYY6 A0A0H4LVL0 A0A0H4LYY2 A0A0H4LYW5 A0A0H4LX50 A0A0H4LYU5 A0A0H4MA83 ENST00000612360.4 A0A0H4M9W5 ENST00000469472.5 ENST00000467814.5 [P17693-2] A0A0H4LU18 A0A0H4LYV8 ENST00000444098.6 [P17693-1] A0A0H4LX29 A0A0H4LX93 ENST00000383622.8 [P17693-3] A0A0H4MA45 ENST00000420559.5 Q95370 A0A0H4LVM7 A0A0H4LZ94 A0A0H4LVD3 A0A0H4LTW4 A0A0H4LVG8 A0A0H4LZ55 A0A0H4LZ21 A0A0H4LXD9 B5LFY1 Q8MH48 ENST00000383623.8 ENST00000412263.6 [P17693-2] A0A0H4LUA0 ENST00000547931.1 [P17693-1] Q6B851 A0A0H4LVN6 ENST00000430253.5 A0A0H4M9X6 ENST00000423011.6 [P17693-1] A0A0H4LX68 A0A0H4MA98 A0A0H4LYZ3 A0A5Q2WTV3 D2KT86 A0A0H4LWY7 ENST00000445373.6 [P17693-3] A0A0H4LXF7 A0A890BW29 A0A0H4LZ14 C0JT29 ENST00000412263.6 A0A0H4LXC4 A0A0H4LVU0 A0A0H4LU60 C0JTC7 ENST00000469347.5 [P17693-2] ENST00000452715.6 ENST00000423373.6 [P17693-1] O02928 O78134 A0A0H4LXB0 A0A0H4LU38 A0A0H4LX13 A0A0H4LYZ8 ENST00000467814.5 A0A0H4MA32 O19767 A0A0H4LYW1 A0A0H4LU44 A0A0H4LVN1 A0A0H4M9Z9 A0A0H4MA03 A0A0H4LX34 A0A3G3C0Z1 A0A0H4LX16 R9X0X9 ENST00000452577.6 A0A0H4LX00 A0A0H4LXA3 ENST00000622601.4 [P17693-3] A0A0H4LVE0 ENST00000478519.5 |
