ANXA5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	47 studies	62% ± 24%	Explore
fibroblast	45 studies	60% ± 23%	Explore
endothelial cell	42 studies	48% ± 18%	Explore
pericyte	36 studies	58% ± 22%	Explore
classical monocyte	29 studies	69% ± 18%	Explore
conventional dendritic cell	29 studies	68% ± 18%	Explore
dendritic cell	28 studies	57% ± 22%	Explore
smooth muscle cell	28 studies	52% ± 18%	Explore
CD8-positive, alpha-beta T cell	26 studies	33% ± 17%	Explore
endothelial cell of lymphatic vessel	25 studies	62% ± 22%	Explore
non-classical monocyte	25 studies	78% ± 16%	Explore
B cell	24 studies	20% ± 4%	Explore
T cell	24 studies	31% ± 15%	Explore
monocyte	24 studies	57% ± 21%	Explore
CD4-positive, alpha-beta T cell	21 studies	31% ± 14%	Explore
basal cell	20 studies	43% ± 14%	Explore
regulatory T cell	20 studies	33% ± 10%	Explore
connective tissue cell	19 studies	61% ± 17%	Explore
mast cell	18 studies	36% ± 13%	Explore
ciliated cell	18 studies	55% ± 21%	Explore
epithelial cell	18 studies	47% ± 25%	Explore
myeloid cell	18 studies	57% ± 27%	Explore
capillary endothelial cell	14 studies	44% ± 12%	Explore
myofibroblast cell	14 studies	64% ± 19%	Explore
gamma-delta T cell	14 studies	26% ± 6%	Explore
endothelial cell of artery	13 studies	45% ± 14%	Explore
endothelial cell of vascular tree	13 studies	52% ± 16%	Explore
natural killer cell	12 studies	24% ± 11%	Explore
plasma cell	12 studies	42% ± 13%	Explore
secretory cell	12 studies	46% ± 13%	Explore
vein endothelial cell	12 studies	43% ± 17%	Explore
memory B cell	12 studies	24% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	29% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 13%	Explore
type I pneumocyte	10 studies	49% ± 20%	Explore
type II pneumocyte	10 studies	42% ± 19%	Explore
plasmablast	10 studies	48% ± 22%	Explore
plasmacytoid dendritic cell	10 studies	27% ± 6%	Explore
mesothelial cell	10 studies	56% ± 15%	Explore
mucosal invariant T cell	10 studies	28% ± 7%	Explore
adipocyte	10 studies	25% ± 8%	Explore
neutrophil	9 studies	35% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	40% ± 20%	Explore
leukocyte	9 studies	39% ± 12%	Explore
naive B cell	9 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	31% ± 7%	Explore
mature NK T cell	9 studies	28% ± 7%	Explore
microglial cell	9 studies	34% ± 18%	Explore
club cell	8 studies	38% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	18% ± 3%	Explore
abnormal cell	8 studies	42% ± 18%	Explore
goblet cell	8 studies	36% ± 16%	Explore
astrocyte	8 studies	31% ± 16%	Explore
alveolar macrophage	7 studies	77% ± 20%	Explore
epithelial cell of proximal tubule	7 studies	27% ± 13%	Explore
ionocyte	6 studies	31% ± 8%	Explore
respiratory goblet cell	6 studies	36% ± 19%	Explore
mononuclear phagocyte	6 studies	69% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	43% ± 10%	Explore
progenitor cell	6 studies	33% ± 20%	Explore
glial cell	6 studies	48% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	39% ± 19%	Explore
hematopoietic precursor cell	5 studies	34% ± 12%	Explore
innate lymphoid cell	5 studies	33% ± 25%	Explore
neuron	5 studies	37% ± 11%	Explore
mucus secreting cell	5 studies	43% ± 21%	Explore
inflammatory macrophage	5 studies	50% ± 19%	Explore
oligodendrocyte	5 studies	23% ± 6%	Explore
T follicular helper cell	5 studies	22% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	47% ± 15%	Explore
intermediate monocyte	5 studies	79% ± 10%	Explore
oligodendrocyte precursor cell	5 studies	34% ± 11%	Explore
melanocyte	5 studies	65% ± 16%	Explore
duct epithelial cell	4 studies	46% ± 11%	Explore
platelet	4 studies	25% ± 10%	Explore
pancreatic A cell	4 studies	58% ± 25%	Explore
monocyte-derived dendritic cell	4 studies	71% ± 21%	Explore
exhausted T cell	4 studies	52% ± 9%	Explore
glomerular endothelial cell	4 studies	39% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	33% ± 8%	Explore
renal alpha-intercalated cell	4 studies	43% ± 8%	Explore
lymphocyte	4 studies	66% ± 19%	Explore
Schwann cell	4 studies	65% ± 21%	Explore
adventitial cell	4 studies	70% ± 11%	Explore
Mueller cell	4 studies	41% ± 11%	Explore
muscle cell	4 studies	36% ± 16%	Explore
CD4-positive helper T cell	4 studies	25% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	51% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 11%	Explore
Langerhans cell	3 studies	71% ± 6%	Explore
pancreatic D cell	3 studies	61% ± 32%	Explore
type B pancreatic cell	3 studies	74% ± 15%	Explore
podocyte	3 studies	51% ± 5%	Explore
renal beta-intercalated cell	3 studies	75% ± 10%	Explore
neural crest cell	3 studies	41% ± 11%	Explore
retinal ganglion cell	3 studies	38% ± 19%	Explore
extravillous trophoblast	3 studies	96% ± 2%	Explore
placental villous trophoblast	3 studies	99% ± 0%	Explore
neuroendocrine cell	3 studies	53% ± 22%	Explore
retinal pigment epithelial cell	3 studies	46% ± 22%	Explore
serous secreting cell	3 studies	38% ± 6%	Explore
tissue-resident macrophage	3 studies	64% ± 18%	Explore
intraepithelial lymphocyte	3 studies	19% ± 4%	Explore
acinar cell	3 studies	52% ± 24%	Explore
chondrocyte	3 studies	47% ± 23%	Explore
endothelial cell of sinusoid	3 studies	33% ± 18%	Explore
myoepithelial cell	3 studies	55% ± 9%	Explore
granulocyte	3 studies	44% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	43% ± 4%	Explore
glutamatergic neuron	3 studies	24% ± 7%	Explore
pancreatic ductal cell	3 studies	90% ± 8%	Explore
enteroendocrine cell	3 studies	39% ± 20%	Explore
hepatocyte	3 studies	41% ± 14%	Explore
T-helper 17 cell	3 studies	35% ± 17%	Explore
T-helper 1 cell	3 studies	40% ± 13%	Explore
hematopoietic stem cell	3 studies	23% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	18% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	28% ± 11%	Explore
double negative thymocyte	3 studies	29% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	52% ± 9%	Explore
erythrocyte	3 studies	23% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	49% ± 15%	Explore
peripheral blood	18 studies	36% ± 9%	Explore
intestine	9 studies	37% ± 23%	Explore
kidney	9 studies	37% ± 13%	Explore
brain	8 studies	28% ± 16%	Explore
pancreas	5 studies	53% ± 28%	Explore
placenta	5 studies	68% ± 32%	Explore
uterus	5 studies	63% ± 11%	Explore
liver	5 studies	25% ± 6%	Explore
bone marrow	4 studies	29% ± 12%	Explore
eye	4 studies	36% ± 18%	Explore
adipose	4 studies	37% ± 7%	Explore
prostate	4 studies	45% ± 6%	Explore
skin	4 studies	39% ± 10%	Explore
breast	4 studies	46% ± 8%	Explore
heart	3 studies	29% ± 6%	Explore
adrenal gland	3 studies	33% ± 6%	Explore
lymph node	3 studies	41% ± 34%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	17061.26	180 / 180	100%	258.98	429 / 430
lung	100%	26247.44	578 / 578	100%	344.30	1151 / 1155
breast	100%	26486.60	459 / 459	99%	408.32	1112 / 1118
prostate	100%	14965.81	244 / 245	100%	464.39	501 / 502
thymus	100%	16907.81	653 / 653	99%	460.47	600 / 605
skin	99%	27994.01	1793 / 1809	100%	1285.47	472 / 472
uterus	100%	21503.44	170 / 170	99%	330.70	453 / 459
kidney	100%	12926.00	89 / 89	99%	404.50	888 / 901
esophagus	99%	13577.70	1434 / 1445	99%	261.11	181 / 183
adrenal gland	100%	22663.91	258 / 258	98%	379.67	225 / 230
stomach	100%	12305.45	359 / 359	98%	256.34	279 / 286
intestine	99%	13020.86	961 / 966	96%	241.61	507 / 527
pancreas	95%	7450.37	312 / 328	99%	490.93	176 / 178
bladder	100%	18248.29	21 / 21	87%	231.96	440 / 504
brain	76%	5489.80	2020 / 2642	100%	470.90	702 / 705
liver	65%	5448.23	148 / 226	82%	202.01	334 / 406
adipose	100%	32157.67	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	1350.44	80 / 80
spleen	100%	14309.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	277.16	45 / 45
blood vessel	100%	26162.97	1334 / 1335	0%	0	0 / 0
heart	98%	10866.84	841 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	262.15	28 / 29
peripheral blood	93%	9701.00	864 / 929	0%	0	0 / 0
muscle	65%	3304.24	523 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050819	Biological process	negative regulation of coagulation
GO_0007165	Biological process	signal transduction
GO_0007596	Biological process	blood coagulation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0012506	Cellular component	vesicle membrane
GO_0016020	Cellular component	membrane
GO_0042383	Cellular component	sarcolemma
GO_0070062	Cellular component	extracellular exosome
GO_0072563	Cellular component	endothelial microparticle
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0005543	Molecular function	phospholipid binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0004859	Molecular function	phospholipase inhibitor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ANXA5
Protein name	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) Annexin A5 Annexin
Synonyms	ANX5 PP4 ENX2
Description	FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. . FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. .
Accessions	P08758 D6RCN3 ENST00000296511.10 ENST00000513728.1 E9PHT9 ENST00000501272.6 ENST00000515017.5 D6RBL5 D6RBE9 ENST00000506395.5

ANXA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review