Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 23406.43 | 653 / 653 | 100% | 172.77 | 605 / 605 |
| prostate | 100% | 12756.92 | 244 / 245 | 99% | 71.85 | 495 / 502 |
| ovary | 100% | 27853.41 | 180 / 180 | 98% | 71.00 | 422 / 430 |
| breast | 100% | 21124.46 | 457 / 459 | 99% | 101.44 | 1102 / 1118 |
| kidney | 99% | 22673.85 | 88 / 89 | 99% | 213.49 | 888 / 901 |
| lung | 100% | 33699.30 | 578 / 578 | 97% | 86.73 | 1116 / 1155 |
| adrenal gland | 98% | 11084.05 | 254 / 258 | 97% | 112.08 | 224 / 230 |
| bladder | 100% | 11967.95 | 21 / 21 | 96% | 72.37 | 482 / 504 |
| uterus | 100% | 15926.52 | 170 / 170 | 93% | 65.04 | 427 / 459 |
| intestine | 94% | 8115.35 | 904 / 966 | 95% | 71.00 | 501 / 527 |
| esophagus | 86% | 8327.80 | 1243 / 1445 | 99% | 85.25 | 181 / 183 |
| skin | 82% | 7465.98 | 1482 / 1809 | 100% | 121.00 | 470 / 472 |
| stomach | 77% | 5412.04 | 275 / 359 | 97% | 84.87 | 276 / 286 |
| pancreas | 40% | 2100.04 | 130 / 328 | 100% | 123.90 | 178 / 178 |
| liver | 50% | 3354.59 | 114 / 226 | 85% | 52.82 | 345 / 406 |
| brain | 19% | 942.01 | 510 / 2642 | 96% | 61.49 | 676 / 705 |
| adipose | 100% | 28150.25 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 104.51 | 80 / 80 |
| heart | 100% | 35145.37 | 861 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 82.35 | 29 / 29 |
| spleen | 100% | 28235.52 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 31.41 | 1 / 1 |
| blood vessel | 97% | 25818.02 | 1296 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 55.50 | 43 / 45 |
| muscle | 76% | 4689.59 | 614 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 3% | 187.07 | 31 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0017015 | Biological process | regulation of transforming growth factor beta receptor signaling pathway |
| GO_0048844 | Biological process | artery morphogenesis |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0055009 | Biological process | atrial cardiac muscle tissue morphogenesis |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0022009 | Biological process | central nervous system vasculogenesis |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0001947 | Biological process | heart looping |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_1905007 | Biological process | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0097084 | Biological process | vascular associated smooth muscle cell development |
| GO_1905222 | Biological process | atrioventricular canal morphogenesis |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0007155 | Biological process | cell adhesion |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0010665 | Biological process | regulation of cardiac muscle cell apoptotic process |
| GO_0003273 | Biological process | cell migration involved in endocardial cushion formation |
| GO_0003208 | Biological process | cardiac ventricle morphogenesis |
| GO_0002040 | Biological process | sprouting angiogenesis |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0003209 | Biological process | cardiac atrium morphogenesis |
| GO_2000136 | Biological process | regulation of cell proliferation involved in heart morphogenesis |
| GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
| GO_0070278 | Biological process | extracellular matrix constituent secretion |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_1905310 | Biological process | regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0060348 | Biological process | bone development |
| GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0048845 | Biological process | venous blood vessel morphogenesis |
| GO_1905065 | Biological process | positive regulation of vascular associated smooth muscle cell differentiation |
| GO_0016477 | Biological process | cell migration |
| GO_0048745 | Biological process | smooth muscle tissue development |
| GO_0090500 | Biological process | endocardial cushion to mesenchymal transition |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0072563 | Cellular component | endothelial microparticle |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0016604 | Cellular component | nuclear body |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0048185 | Molecular function | activin binding |
| GO_0034713 | Molecular function | type I transforming growth factor beta receptor binding |
| GO_0050431 | Molecular function | transforming growth factor beta binding |
| GO_0036122 | Molecular function | BMP binding |
| GO_0005534 | Molecular function | galactose binding |
| GO_0005024 | Molecular function | transforming growth factor beta receptor activity |
| GO_0005114 | Molecular function | type II transforming growth factor beta receptor binding |
| GO_0005539 | Molecular function | glycosaminoglycan binding |
| GO_0030546 | Molecular function | signaling receptor activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ENG |
| Protein name | ENG protein (Endoglin (Osler-Rendu-Weber syndrome 1)) Endoglin Endoglin (CD antigen CD105) Endoglin (Osler-Rendu-Weber syndrome 1) |
| Synonyms | END hCG_18549 |
| Description | FUNCTION: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis . Required for normal structure and integrity of adult vasculature . Regulates the migration of vascular endothelial cells . Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors . Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors . Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 . . |
| Accessions | ENST00000480266.6 Q5T9B9 ENST00000344849.4 [P17813-2] P17813 Q96CG0 ENST00000373203.9 [P17813-1] F5GX88 |
