TRPV1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRPV1 at tissue level.

III. Associated gene sets

GO_0071502Biological processcellular response to temperature stimulus
GO_0001774Biological processmicroglial cell activation
GO_0043434Biological processresponse to peptide hormone
GO_0019722Biological processcalcium-mediated signaling
GO_0034605Biological processcellular response to heat
GO_1901594Biological processresponse to capsazepine
GO_0060079Biological processexcitatory postsynaptic potential
GO_0007635Biological processchemosensory behavior
GO_0002024Biological processdiet induced thermogenesis
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0010459Biological processnegative regulation of heart rate
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0002790Biological processpeptide secretion
GO_0071468Biological processcellular response to acidic pH
GO_0071318Biological processcellular response to ATP
GO_0050968Biological processdetection of chemical stimulus involved in sensory perception of pain
GO_0003085Biological processnegative regulation of systemic arterial blood pressure
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0050954Biological processsensory perception of mechanical stimulus
GO_0071312Biological processcellular response to alkaloid
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0090212Biological processnegative regulation of establishment of blood-brain barrier
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0010917Biological processnegative regulation of mitochondrial membrane potential
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0050960Biological processdetection of temperature stimulus involved in thermoception
GO_0050955Biological processthermoception
GO_0048266Biological processbehavioral response to pain
GO_0001660Biological processfever generation
GO_0006629Biological processlipid metabolic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0014047Biological processglutamate secretion
GO_0070588Biological processcalcium ion transmembrane transport
GO_0060083Biological processsmooth muscle contraction involved in micturition
GO_0007166Biological processcell surface receptor signaling pathway
GO_0051289Biological processprotein homotetramerization
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043025Cellular componentneuronal cell body
GO_0032591Cellular componentdendritic spine membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005231Molecular functionexcitatory extracellular ligand-gated monoatomic ion channel activity
GO_0042802Molecular functionidentical protein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0017081Molecular functionchloride channel regulator activity
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005230Molecular functionextracellular ligand-gated monoatomic ion channel activity
GO_0015278Molecular functionintracellularly gated calcium channel activity
GO_0005516Molecular functioncalmodulin binding
GO_0097603Molecular functiontemperature-gated ion channel activity
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTRPV1
Protein nameTransient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)
Transient receptor potential cation channel subfamily V member 1 (Osm-9-like TRP channel 1) (Vanilloid receptor 1)
Transient receptor potential cation channel subfamily V member 1
SynonymsVR1
DescriptionFUNCTION: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. .

AccessionsE7EQ78
Q3LU46
ENST00000572705.2 [Q8NER1-1]
Q8NER1
ENST00000571088.5 [Q8NER1-1]
E7ESJ2
A0A3B3ISI9
I3L1R6
ENST00000650505.1
Q52PU4
ENST00000399756.8 [Q8NER1-1]
Q09HS5
ENST00000576351.5
ENST00000310522.5
ENST00000425167.6
ENST00000399759.7 [Q8NER1-1]