CCR4 | OmnibusX

Name	Number of supported studies	Average coverage
regulatory T cell	7 studies	19% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCR4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	240.21	576 / 578	80%	4.50	920 / 1155
breast	69%	37.45	319 / 459	80%	4.86	896 / 1118
intestine	48%	72.07	467 / 966	62%	2.35	329 / 527
stomach	40%	15.62	145 / 359	69%	2.87	198 / 286
kidney	49%	39.09	44 / 89	56%	2.27	504 / 901
thymus	55%	51.04	357 / 653	48%	2.13	288 / 605
prostate	51%	41.14	125 / 245	48%	1.51	241 / 502
spleen	98%	266.07	235 / 241	0%	0	0 / 0
skin	53%	31.70	962 / 1809	43%	1.75	202 / 472
peripheral blood	95%	270.02	884 / 929	0%	0	0 / 0
bladder	38%	28.71	8 / 21	54%	1.90	270 / 504
esophagus	31%	21.40	453 / 1445	56%	2.15	102 / 183
lymph node	0%	0	0 / 0	83%	15.01	24 / 29
adipose	80%	48.96	965 / 1204	0%	0	0 / 0
uterus	36%	12.99	62 / 170	42%	1.48	195 / 459
tonsil	0%	0	0 / 0	76%	5.74	34 / 45
pancreas	6%	1.69	20 / 328	67%	3.92	120 / 178
liver	32%	9.99	73 / 226	19%	0.50	79 / 406
blood vessel	42%	24.66	560 / 1335	0%	0	0 / 0
adrenal gland	35%	9.95	90 / 258	4%	0.06	9 / 230
ovary	13%	3.84	23 / 180	25%	0.50	108 / 430
heart	21%	8.65	184 / 861	0%	0	0 / 0
brain	1%	0.18	18 / 2642	5%	0.13	33 / 705
eye	0%	0	0 / 0	4%	0.07	3 / 80
muscle	1%	0.38	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0002507	Biological process	tolerance induction
GO_0006954	Biological process	inflammatory response
GO_0019722	Biological process	calcium-mediated signaling
GO_0009617	Biological process	response to bacterium
GO_0006935	Biological process	chemotaxis
GO_0048872	Biological process	homeostasis of number of cells
GO_0006955	Biological process	immune response
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_1904936	Biological process	interneuron migration
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0060326	Biological process	cell chemotaxis
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0043025	Cellular component	neuronal cell body
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0004950	Molecular function	chemokine receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0005515	Molecular function	protein binding

Gene name	CCR4
Protein name	Chemokine (C-C motif) receptor 4 (cDNA FLJ75821, highly similar to Homo sapiens chemokine (C-C motif) receptor 4 (CCR4), mRNA) C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Synonyms	CMKBR4 hCG_1776165
Description	FUNCTION: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. .
Accessions	ENST00000330953.6 P51679 A0N0Q1

CCR4 report