ICAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0022614Biological processmembrane to membrane docking
GO_0071333Biological processcellular response to glucose stimulus
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0033627Biological processcell adhesion mediated by integrin
GO_0001910Biological processregulation of leukocyte mediated cytotoxicity
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0007155Biological processcell adhesion
GO_0002693Biological processpositive regulation of cellular extravasation
GO_0002291Biological processT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0046813Biological processreceptor-mediated virion attachment to host cell
GO_0046718Biological processsymbiont entry into host cell
GO_0050900Biological processleukocyte migration
GO_0044406Biological processadhesion of symbiont to host
GO_0002457Biological processT cell antigen processing and presentation
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0061028Biological processestablishment of endothelial barrier
GO_0072683Biological processT cell extravasation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1904646Biological processcellular response to amyloid-beta
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_1900027Biological processregulation of ruffle assembly
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0001772Cellular componentimmunological synapse
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0038023Molecular functionsignaling receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0001618Molecular functionvirus receptor activity
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameICAM1
Protein nameIntercellular adhesion molecule 1
Intercellular adhesion molecule-1
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Synonyms
DescriptionFUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. .; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. .; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. .; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. .

FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. .

AccessionsA0A1C9J7T1
ENST00000588645.1
Q5NKV8
ENST00000423829.2
K7EKL8
Q14601
ENST00000264832.8
E7ESS4
P05362