Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 29 studies | 37% ± 17% | |
| macrophage | 28 studies | 30% ± 12% | |
| fibroblast | 22 studies | 31% ± 10% | |
| classical monocyte | 19 studies | 27% ± 8% | |
| conventional dendritic cell | 16 studies | 25% ± 9% | |
| mast cell | 14 studies | 25% ± 9% | |
| non-classical monocyte | 14 studies | 28% ± 10% | |
| dendritic cell | 12 studies | 32% ± 13% | |
| monocyte | 12 studies | 36% ± 10% | |
| type I pneumocyte | 12 studies | 62% ± 19% | |
| type II pneumocyte | 12 studies | 36% ± 15% | |
| vein endothelial cell | 12 studies | 36% ± 15% | |
| plasmacytoid dendritic cell | 10 studies | 26% ± 11% | |
| endothelial cell of artery | 10 studies | 26% ± 10% | |
| endothelial cell of vascular tree | 10 studies | 51% ± 18% | |
| capillary endothelial cell | 9 studies | 31% ± 9% | |
| pericyte | 8 studies | 25% ± 4% | |
| myeloid cell | 8 studies | 33% ± 14% | |
| mononuclear phagocyte | 5 studies | 33% ± 11% | |
| basal cell | 5 studies | 24% ± 5% | |
| club cell | 5 studies | 32% ± 21% | |
| neutrophil | 4 studies | 33% ± 12% | |
| natural killer cell | 4 studies | 22% ± 6% | |
| CD16-negative, CD56-bright natural killer cell, human | 4 studies | 31% ± 6% | |
| secretory cell | 4 studies | 25% ± 7% | |
| connective tissue cell | 4 studies | 29% ± 8% | |
| tissue-resident macrophage | 3 studies | 40% ± 22% | |
| intermediate monocyte | 3 studies | 32% ± 15% | |
| monocyte-derived dendritic cell | 3 studies | 24% ± 7% | |
| smooth muscle cell | 3 studies | 19% ± 2% | |
| leukocyte | 3 studies | 24% ± 3% | |
| ciliated cell | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 19827.35 | 578 / 578 | 95% | 170.92 | 1098 / 1155 |
| thymus | 99% | 3258.30 | 647 / 653 | 85% | 77.39 | 512 / 605 |
| skin | 85% | 1620.85 | 1529 / 1809 | 97% | 154.49 | 457 / 472 |
| kidney | 97% | 2667.96 | 86 / 89 | 82% | 61.93 | 737 / 901 |
| breast | 100% | 3347.09 | 459 / 459 | 78% | 41.70 | 868 / 1118 |
| intestine | 89% | 1768.11 | 855 / 966 | 77% | 37.89 | 406 / 527 |
| uterus | 86% | 1331.79 | 146 / 170 | 75% | 49.42 | 346 / 459 |
| esophagus | 77% | 1165.19 | 1106 / 1445 | 83% | 59.12 | 152 / 183 |
| stomach | 70% | 1641.05 | 251 / 359 | 83% | 55.74 | 237 / 286 |
| bladder | 86% | 1394.19 | 18 / 21 | 67% | 52.27 | 336 / 504 |
| ovary | 63% | 1088.44 | 114 / 180 | 81% | 63.10 | 349 / 430 |
| liver | 79% | 2556.31 | 179 / 226 | 64% | 44.02 | 260 / 406 |
| prostate | 83% | 1690.69 | 204 / 245 | 45% | 15.40 | 226 / 502 |
| pancreas | 36% | 455.73 | 118 / 328 | 87% | 52.00 | 154 / 178 |
| spleen | 100% | 4757.58 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 6078.27 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 42.99 | 76 / 80 |
| peripheral blood | 95% | 3621.14 | 879 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 78% | 1467.07 | 201 / 258 | 17% | 5.44 | 38 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 105.81 | 42 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 107.69 | 27 / 29 |
| blood vessel | 86% | 1863.30 | 1149 / 1335 | 0% | 0 | 0 / 0 |
| heart | 78% | 1972.70 | 674 / 861 | 0% | 0 | 0 / 0 |
| muscle | 50% | 690.98 | 400 / 803 | 0% | 0 | 0 / 0 |
| brain | 18% | 263.89 | 470 / 2642 | 29% | 13.33 | 206 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0022614 | Biological process | membrane to membrane docking |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0001910 | Biological process | regulation of leukocyte mediated cytotoxicity |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0007155 | Biological process | cell adhesion |
| GO_0002693 | Biological process | positive regulation of cellular extravasation |
| GO_0002291 | Biological process | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| GO_0046813 | Biological process | receptor-mediated virion attachment to host cell |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0050900 | Biological process | leukocyte migration |
| GO_0044406 | Biological process | adhesion of symbiont to host |
| GO_0002457 | Biological process | T cell antigen processing and presentation |
| GO_1902042 | Biological process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0072683 | Biological process | T cell extravasation |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0007157 | Biological process | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO_1900027 | Biological process | regulation of ruffle assembly |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0001772 | Cellular component | immunological synapse |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0009986 | Cellular component | cell surface |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0005178 | Molecular function | integrin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ICAM1 |
| Protein name | Intercellular adhesion molecule 1 Intercellular adhesion molecule-1 Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) |
| Synonyms | |
| Description | FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. .; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. .; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. .; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. . FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. . |
| Accessions | A0A1C9J7T1 ENST00000588645.1 Q5NKV8 ENST00000423829.2 K7EKL8 Q14601 ENST00000264832.8 E7ESS4 P05362 |