CD79A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0050853Biological processB cell receptor signaling pathway
GO_0042100Biological processB cell proliferation
GO_0042113Biological processB cell activation
GO_0030183Biological processB cell differentiation
GO_0071755Cellular componentIgM B cell receptor complex
GO_0045121Cellular componentmembrane raft
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005771Cellular componentmultivesicular body
GO_0019815Cellular componentB cell receptor complex
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD79A
Protein nameCD79a molecule
B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
SynonymsMB1
IGA
DescriptionFUNCTION: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. .

AccessionsENST00000597454.2
ENST00000444740.2 [P11912-2]
M0QX61
P11912
ENST00000221972.8 [P11912-1]