Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 48 studies | 79% ± 20% | |
plasma cell | 24 studies | 63% ± 20% | |
memory B cell | 21 studies | 87% ± 18% | |
naive B cell | 20 studies | 90% ± 7% | |
plasmablast | 12 studies | 62% ± 20% | |
IgG plasma cell | 9 studies | 60% ± 21% | |
IgA plasma cell | 8 studies | 53% ± 23% | |
precursor B cell | 7 studies | 84% ± 12% | |
immature B cell | 7 studies | 92% ± 12% | |
pro-B cell | 5 studies | 75% ± 11% | |
germinal center B cell | 4 studies | 77% ± 17% | |
IgM plasma cell | 4 studies | 59% ± 30% | |
follicular B cell | 3 studies | 82% ± 13% | |
erythrocyte | 3 studies | 34% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 81% | 267.53 | 470 / 578 | 82% | 70.71 | 949 / 1155 |
stomach | 63% | 349.77 | 225 / 359 | 62% | 70.99 | 178 / 286 |
intestine | 54% | 2020.59 | 525 / 966 | 54% | 49.15 | 286 / 527 |
lymph node | 0% | 0 | 0 / 0 | 100% | 2415.23 | 29 / 29 |
spleen | 100% | 13789.79 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 8597.03 | 927 / 929 | 0% | 0 | 0 / 0 |
breast | 37% | 140.43 | 171 / 459 | 49% | 32.20 | 551 / 1118 |
tonsil | 0% | 0 | 0 / 0 | 82% | 117.14 | 37 / 45 |
esophagus | 22% | 88.57 | 323 / 1445 | 50% | 29.73 | 92 / 183 |
bladder | 24% | 162.05 | 5 / 21 | 44% | 35.06 | 222 / 504 |
thymus | 23% | 424.09 | 151 / 653 | 40% | 61.92 | 244 / 605 |
pancreas | 2% | 2.96 | 8 / 328 | 54% | 62.53 | 97 / 178 |
skin | 1% | 2.69 | 27 / 1809 | 51% | 64.21 | 243 / 472 |
kidney | 30% | 179.80 | 27 / 89 | 21% | 8.83 | 189 / 901 |
uterus | 9% | 11.89 | 15 / 170 | 39% | 17.61 | 180 / 459 |
prostate | 26% | 101.55 | 63 / 245 | 21% | 8.33 | 106 / 502 |
ovary | 11% | 15.54 | 19 / 180 | 31% | 11.58 | 134 / 430 |
liver | 19% | 23.90 | 43 / 226 | 14% | 11.96 | 57 / 406 |
adipose | 21% | 65.53 | 251 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 6% | 12.98 | 16 / 258 | 9% | 6.50 | 20 / 230 |
blood vessel | 10% | 49.37 | 130 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 5.69 | 5 / 80 |
heart | 3% | 11.79 | 30 / 861 | 0% | 0 | 0 / 0 |
muscle | 2% | 3.16 | 20 / 803 | 0% | 0 | 0 / 0 |
brain | 0% | 0.76 | 9 / 2642 | 1% | 3.29 | 10 / 705 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002250 | Biological process | adaptive immune response |
GO_0050853 | Biological process | B cell receptor signaling pathway |
GO_0042100 | Biological process | B cell proliferation |
GO_0042113 | Biological process | B cell activation |
GO_0030183 | Biological process | B cell differentiation |
GO_0071755 | Cellular component | IgM B cell receptor complex |
GO_0045121 | Cellular component | membrane raft |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005771 | Cellular component | multivesicular body |
GO_0019815 | Cellular component | B cell receptor complex |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CD79A |
Protein name | CD79a molecule B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a) |
Synonyms | MB1 IGA |
Description | FUNCTION: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. . |
Accessions | ENST00000597454.2 ENST00000444740.2 [P11912-2] M0QX61 P11912 ENST00000221972.8 [P11912-1] |