KLRK1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	8 studies	42% ± 18%	Explore
CD8-positive, alpha-beta T cell	8 studies	37% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	40% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	52% ± 23%	Explore
gamma-delta T cell	6 studies	46% ± 21%	Explore
mature NK T cell	6 studies	48% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	35% ± 12%	Explore
mucosal invariant T cell	4 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	42% ± 27%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	50% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	33% ± 5%	Explore
lymphocyte	3 studies	21% ± 3%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1200.10	578 / 578	10%	0.18	115 / 1155
spleen	100%	3905.06	241 / 241	0%	0	0 / 0
thymus	95%	418.51	621 / 653	4%	0.08	27 / 605
stomach	92%	310.52	332 / 359	2%	0.03	6 / 286
adipose	94%	403.55	1135 / 1204	0%	0	0 / 0
prostate	93%	301.85	227 / 245	1%	0.02	6 / 502
uterus	80%	178.59	136 / 170	9%	0.15	42 / 459
liver	88%	276.96	199 / 226	1%	0.01	3 / 406
breast	83%	250.93	383 / 459	4%	0.06	41 / 1118
peripheral blood	86%	2170.37	797 / 929	0%	0	0 / 0
esophagus	77%	136.83	1116 / 1445	2%	0.03	4 / 183
brain	53%	70.40	1390 / 2642	26%	0.52	182 / 705
intestine	72%	390.29	692 / 966	3%	0.05	15 / 527
bladder	67%	304.48	14 / 21	6%	0.10	30 / 504
kidney	61%	177.98	54 / 89	11%	0.22	98 / 901
skin	51%	95.24	921 / 1809	13%	0.31	61 / 472
adrenal gland	52%	81.29	133 / 258	0%	0.01	1 / 230
blood vessel	50%	122.44	668 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	1.13	14 / 29
ovary	46%	84.28	82 / 180	1%	0.01	3 / 430
heart	41%	66.63	354 / 861	0%	0	0 / 0
pancreas	30%	38.48	97 / 328	6%	0.08	10 / 178
tonsil	0%	0	0 / 0	16%	0.23	7 / 45
muscle	7%	7.83	58 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034260	Biological process	negative regulation of GTPase activity
GO_2000502	Biological process	negative regulation of natural killer cell chemotaxis
GO_0045954	Biological process	positive regulation of natural killer cell mediated cytotoxicity
GO_0007165	Biological process	signal transduction
GO_0031295	Biological process	T cell costimulation
GO_0030101	Biological process	natural killer cell activation
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0002250	Biological process	adaptive immune response
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0030154	Biological process	cell differentiation
GO_0006809	Biological process	nitric oxide biosynthetic process
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0009986	Cellular component	cell surface
GO_0038023	Molecular function	signaling receptor activity
GO_0030246	Molecular function	carbohydrate binding
GO_0042802	Molecular function	identical protein binding
GO_0042288	Molecular function	MHC class I protein binding
GO_0032394	Molecular function	MHC class Ib receptor activity
GO_0005515	Molecular function	protein binding

Gene name	KLRK1
Protein name	NK cell receptor D Killer cell lectin like receptor K1 (NKG2-D type II integral membrane protein) NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Synonyms	NKG2D D12S2489E
Description	FUNCTION: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. .
Accessions	Q1HEA1 P26718 J7GQY5 Q8WZ67 ENST00000540818.5 [P26718-1] ENST00000240618.11 [P26718-1] ENST00000396451.4

KLRK1 report