IL31RA report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL31RA at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL31RA at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0043031Biological processnegative regulation of macrophage activation
GO_0098542Biological processdefense response to other organism
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0000165Biological processMAPK cascade
GO_0030225Biological processmacrophage differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0002067Biological processglandular epithelial cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0042592Biological processhomeostatic process
GO_0030224Biological processmonocyte differentiation
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0006952Biological processdefense response
GO_0002438Biological processacute inflammatory response to antigenic stimulus
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030424Cellular componentaxon
GO_0019955Molecular functioncytokine binding
GO_0019901Molecular functionprotein kinase binding
GO_0004896Molecular functioncytokine receptor activity
GO_0003713Molecular functiontranscription coactivator activity

IV. Literature review

[source]
Gene nameIL31RA
Protein nameInterleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
Interleukin 31 receptor A
SynonymsCRL3
UNQ6368/PRO21073/PRO21384
GPL
DescriptionFUNCTION: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 . May function in skin immunity . Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). .

AccessionsENST00000396834.6
ENST00000354961.8 [Q8NI17-3]
ENST00000611895.1
ENST00000652347.2 [Q8NI17-2]
ENST00000652039.1
ENST00000396836.6 [Q8NI17-8]
A0A0C4DGU4
ENST00000359040.10 [Q8NI17-5]
ENST00000297015.7 [Q8NI17-12]
A0A499FJ31
ENST00000490985.5 [Q8NI17-6]
ENST00000651239.1
A0A494C190
A0A494BZY2
Q8NI17