MPL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of MPL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	94%	13.14	230 / 245	64%	0.96	322 / 502
ovary	97%	31.36	175 / 180	50%	0.92	216 / 430
thymus	98%	20.90	643 / 653	47%	0.74	283 / 605
esophagus	92%	13.93	1328 / 1445	36%	0.85	66 / 183
brain	89%	15.77	2350 / 2642	35%	0.65	244 / 705
kidney	83%	9.46	74 / 89	40%	0.64	356 / 901
lung	97%	36.99	563 / 578	20%	0.31	232 / 1155
breast	98%	20.79	450 / 459	19%	0.29	207 / 1118
uterus	98%	18.84	167 / 170	14%	0.23	62 / 459
intestine	92%	12.08	891 / 966	13%	0.19	69 / 527
pancreas	84%	8.67	276 / 328	21%	0.42	37 / 178
stomach	82%	8.67	296 / 359	20%	0.34	58 / 286
adipose	95%	20.37	1146 / 1204	0%	0	0 / 0
spleen	94%	14.29	227 / 241	0%	0	0 / 0
bladder	86%	14.76	18 / 21	8%	0.12	41 / 504
blood vessel	93%	14.07	1248 / 1335	0%	0	0 / 0
heart	92%	14.72	790 / 861	0%	0	0 / 0
adrenal gland	79%	7.60	205 / 258	6%	0.08	13 / 230
skin	68%	8.39	1227 / 1809	3%	0.06	16 / 472
peripheral blood	69%	10.44	639 / 929	0%	0	0 / 0
muscle	62%	5.00	499 / 803	0%	0	0 / 0
liver	35%	2.20	78 / 226	8%	0.13	34 / 406
eye	0%	0	0 / 0	5%	0.06	4 / 80
tonsil	0%	0	0 / 0	4%	0.06	2 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001780	Biological process	neutrophil homeostasis
GO_0038163	Biological process	thrombopoietin-mediated signaling pathway
GO_0050671	Biological process	positive regulation of lymphocyte proliferation
GO_0016064	Biological process	immunoglobulin mediated immune response
GO_1905221	Biological process	positive regulation of platelet formation
GO_1990959	Biological process	eosinophil homeostasis
GO_0035702	Biological process	monocyte homeostasis
GO_1990960	Biological process	basophil homeostasis
GO_0071456	Biological process	cellular response to hypoxia
GO_0009986	Cellular component	cell surface
GO_0009897	Cellular component	external side of plasma membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0031965	Cellular component	nuclear membrane
GO_0043025	Cellular component	neuronal cell body
GO_0038164	Molecular function	thrombopoietin receptor activity
GO_0005515	Molecular function	protein binding

Gene name	MPL
Protein name	Thrombopoietin receptor variant MPL proto-oncogene, thrombopoietin receptor Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) MPL Myeloproliferative leukemia protein
Synonyms	TPOR
Description	FUNCTION: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. .
Accessions	Q5JUY5 P40238 A0A142IKC6 A0A142IKC3 W8QGV4 A0A2H4PKE3 A0A2R8YE13 ENST00000413998.7 ENST00000372470.9 [P40238-1] ENST00000643351.1

MPL report