ITGA8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0033627Biological processcell adhesion mediated by integrin
GO_0007160Biological processcell-matrix adhesion
GO_0045184Biological processestablishment of protein localization
GO_0001656Biological processmetanephros development
GO_0030198Biological processextracellular matrix organization
GO_0001822Biological processkidney development
GO_0030030Biological processcell projection organization
GO_0048333Biological processmesodermal cell differentiation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0051145Biological processsmooth muscle cell differentiation
GO_0042472Biological processinner ear morphogenesis
GO_0007613Biological processmemory
GO_0098609Biological processcell-cell adhesion
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0048745Biological processsmooth muscle tissue development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0008305Cellular componentintegrin complex
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0032591Cellular componentdendritic spine membrane
GO_0034678Cellular componentintegrin alpha8-beta1 complex
GO_0045177Cellular componentapical part of cell
GO_0005178Molecular functionintegrin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameITGA8
Protein nameIntegrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Synonyms
DescriptionFUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. .

AccessionsP53708
ENST00000378076.4