HLA-E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002717Biological processpositive regulation of natural killer cell mediated immunity
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0002476Biological processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO_0002715Biological processregulation of natural killer cell mediated immunity
GO_0002486Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO_0045087Biological processinnate immune response
GO_0019731Biological processantibacterial humoral response
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0002519Biological processnatural killer cell tolerance induction
GO_0002729Biological processpositive regulation of natural killer cell cytokine production
GO_0001815Biological processpositive regulation of antibody-dependent cellular cytotoxicity
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0032759Biological processpositive regulation of TRAIL production
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0045953Biological processnegative regulation of natural killer cell mediated cytotoxicity
GO_0042270Biological processprotection from natural killer cell mediated cytotoxicity
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0032815Biological processnegative regulation of natural killer cell activation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0032816Biological processpositive regulation of natural killer cell activation
GO_2001187Biological processpositive regulation of CD8-positive, alpha-beta T cell activation
GO_0036037Biological processCD8-positive, alpha-beta T cell activation
GO_2000566Biological processpositive regulation of CD8-positive, alpha-beta T cell proliferation
GO_0002477Biological processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0042612Cellular componentMHC class I protein complex
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0032398Cellular componentMHC class Ib protein complex
GO_0042608Molecular functionT cell receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0042288Molecular functionMHC class I protein binding
GO_0046703Molecular functionnatural killer cell lectin-like receptor binding
GO_0030881Molecular functionbeta-2-microglobulin binding
GO_0005515Molecular functionprotein binding
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameHLA-E
Protein nameHLA-E protein
HLA-E
MHC class I antigen
HLA-E (Leucocyte Antigen) (MHC class I antigen) (MHC class Ib antigen) (Major histocompatibility complex, class I, E)
MHC class Ib antigen
MHC antigen
Leucocyte Antigen
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Major histocompatibility complex, class I, E
SynonymshCG_26010
HLA-6.2
HLAE
DescriptionFUNCTION: Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides - VMAPRT[V/L][L/V/I/F]L) . Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self . Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells . Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy . Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8-positive cytotoxic T cells, ultimately triggering antimicrobial immune response . Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV17-containing TCR, triggering HLA-E-restricted T cell responses . Presents mycobacterial peptides to HLA-E-restricted CD8-positive T cells eliciting both cytotoxic and immunoregulatory functions . .; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. .; FUNCTION: (Microbial infection) May bind HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. .; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells . Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening of antiviral immune surveillance . .

AccessionsENST00000383597.6
S4W2A6
ENST00000415649.4
ENST00000415289.4
A0A0F7W1Q1
A0A5C0C6I5
W0NXW9
Q2L6I5
Q6KBZ5
ENST00000425603.4
A0A4E9D3W4
A0A7L7TM74
Q9TNU7
A0A4E9DQ67
ENST00000444683.4
Q6DU50
ENST00000376630.5
Q9MW44
A0A4E9E4P1
A0A0A8LFF7
A0A0F7WBW2
P13747
ENST00000427936.4
O19682
I3RW89
S5RFZ0
A0A4E9E9K8
W0NTJ0