ITGAL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	34% ± 12%	Explore
non-classical monocyte	23 studies	39% ± 18%	Explore
CD8-positive, alpha-beta T cell	22 studies	28% ± 11%	Explore
T cell	20 studies	25% ± 8%	Explore
mature NK T cell	16 studies	28% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	42% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 8%	Explore
regulatory T cell	15 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	13 studies	22% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 8%	Explore
classical monocyte	12 studies	26% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	31% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	24% ± 8%	Explore
monocyte	10 studies	24% ± 7%	Explore
mucosal invariant T cell	9 studies	24% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	28% ± 8%	Explore
exhausted T cell	5 studies	37% ± 10%	Explore
lymphocyte	5 studies	39% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	32% ± 6%	Explore
leukocyte	4 studies	27% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
myeloid cell	4 studies	17% ± 2%	Explore
T follicular helper cell	4 studies	24% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
microglial cell	4 studies	21% ± 5%	Explore
conventional dendritic cell	3 studies	40% ± 12%	Explore
plasma cell	3 studies	29% ± 3%	Explore
innate lymphoid cell	3 studies	23% ± 6%	Explore
dendritic cell	3 studies	36% ± 8%	Explore
alveolar macrophage	3 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 11%	Explore
double negative thymocyte	3 studies	30% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	35% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	22% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4493.40	578 / 578	90%	9.76	1043 / 1155
liver	99%	1359.01	224 / 226	91%	8.30	370 / 406
breast	69%	501.43	316 / 459	92%	10.15	1030 / 1118
stomach	69%	541.01	247 / 359	76%	6.08	217 / 286
kidney	54%	568.21	48 / 89	86%	9.77	771 / 901
thymus	73%	905.16	475 / 653	65%	11.06	394 / 605
prostate	68%	619.88	167 / 245	57%	2.66	288 / 502
bladder	67%	788.33	14 / 21	58%	4.32	293 / 504
intestine	58%	1525.50	561 / 966	67%	4.71	351 / 527
uterus	47%	284.57	80 / 170	65%	5.00	298 / 459
lymph node	0%	0	0 / 0	100%	69.62	29 / 29
peripheral blood	100%	17726.63	929 / 929	0%	0	0 / 0
spleen	100%	16043.54	241 / 241	0%	0	0 / 0
esophagus	27%	189.71	393 / 1445	69%	4.57	126 / 183
tonsil	0%	0	0 / 0	89%	13.71	40 / 45
pancreas	11%	70.60	37 / 328	76%	6.46	136 / 178
skin	11%	57.45	193 / 1809	72%	11.85	341 / 472
adipose	80%	768.11	962 / 1204	0%	0	0 / 0
brain	16%	96.28	417 / 2642	57%	3.20	404 / 705
ovary	14%	86.22	26 / 180	56%	2.80	242 / 430
adrenal gland	29%	145.81	76 / 258	23%	0.77	52 / 230
blood vessel	31%	300.64	418 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	24%	1.96	19 / 80
heart	20%	113.59	176 / 861	0%	0	0 / 0
muscle	2%	7.34	13 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0006954	Biological process	inflammatory response
GO_0035683	Biological process	memory T cell extravasation
GO_0007160	Biological process	cell-matrix adhesion
GO_0007165	Biological process	signal transduction
GO_0007155	Biological process	cell adhesion
GO_0002291	Biological process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0043113	Biological process	receptor clustering
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0006909	Biological process	phagocytosis
GO_0098609	Biological process	cell-cell adhesion
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0009897	Cellular component	external side of plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0008305	Cellular component	integrin complex
GO_0034687	Cellular component	integrin alphaL-beta2 complex
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0005178	Molecular function	integrin binding
GO_0046872	Molecular function	metal ion binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0005515	Molecular function	protein binding
GO_0030369	Molecular function	ICAM-3 receptor activity

IV. Literature review

[source]

Gene name	ITGAL
Protein name	Integrin subunit alpha L (cDNA FLJ56671, highly similar to Integrin alpha-L) Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) Integrin subunit alpha L Integrin subunit alpha L (cDNA FLJ57691, highly similar to Integrin alpha-L)
Synonyms	CD11A
Description	FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R . Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL . Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity . Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils . Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages . .
Accessions	B4DQ77 A0A7I2V4B0 I3L1D1 I3L468 H3BS37 ENST00000679323.1 ENST00000433423.2 ENST00000678203.1 A0A7I2V5G1 ENST00000565864.5 ENST00000562652.1 ENST00000358164.9 [P20701-3] ENST00000677830.1 P20701 B4E021 ENST00000568926.5 ENST00000569725.1 A0A7I2V498 H3BNL5 A0A7I2V582 ENST00000562857.5 H3BUT3 ENST00000676652.1 ENST00000356798.11 [P20701-1] ENST00000563615.5

ITGAL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review