CXCL10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CXCL10 at tissue level.

III. Associated gene sets

GO_0010996Biological processresponse to auditory stimulus
GO_1901509Biological processregulation of endothelial tube morphogenesis
GO_0006954Biological processinflammatory response
GO_0034605Biological processcellular response to heat
GO_0097398Biological processcellular response to interleukin-17
GO_0050918Biological processpositive chemotaxis
GO_0010332Biological processresponse to gamma radiation
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0007165Biological processsignal transduction
GO_0090026Biological processpositive regulation of monocyte chemotaxis
GO_0030593Biological processneutrophil chemotaxis
GO_0006935Biological processchemotaxis
GO_0042118Biological processendothelial cell activation
GO_0007267Biological processcell-cell signaling
GO_0016525Biological processnegative regulation of angiogenesis
GO_0098586Biological processcellular response to virus
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_1901740Biological processnegative regulation of myoblast fusion
GO_0008015Biological processblood circulation
GO_0007517Biological processmuscle organ development
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0010818Biological processT cell chemotaxis
GO_2000406Biological processpositive regulation of T cell migration
GO_0010819Biological processregulation of T cell chemotaxis
GO_0033280Biological processresponse to vitamin D
GO_0042127Biological processregulation of cell population proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140374Biological processantiviral innate immune response
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0008201Molecular functionheparin binding
GO_0048248Molecular functionCXCR3 chemokine receptor binding
GO_0008009Molecular functionchemokine activity
GO_0008603Molecular functioncAMP-dependent protein kinase regulator activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042056Molecular functionchemoattractant activity
GO_0045236Molecular functionCXCR chemokine receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCXCL10
Protein nameC-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
SynonymsINP10
SCYB10
DescriptionFUNCTION: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects . Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization . In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation . Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). .

AccessionsENST00000306602.3
P02778