CD84 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043305Biological processnegative regulation of mast cell degranulation
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0043030Biological processregulation of macrophage activation
GO_0002250Biological processadaptive immune response
GO_0032701Biological processnegative regulation of interleukin-18 production
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0032685Biological processnegative regulation of granulocyte macrophage colony-stimulating factor production
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0006914Biological processautophagy
GO_2001256Biological processregulation of store-operated calcium entry
GO_0033004Biological processnegative regulation of mast cell activation
GO_0042110Biological processT cell activation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0006952Biological processdefense response
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD84
Protein nameLeucocyte differentiation antigen CD84
SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
Alternative protein CD84
SynonymsSLAMF5
DescriptionFUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 . In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 . .

AccessionsQ9UIB8
L8E7X8
ENST00000368051.3 [Q9UIB8-5]
ENST00000368054.8 [Q9UIB8-3]
ENST00000534968.5 [Q9UIB8-7]
ENST00000311224.8 [Q9UIB8-1]
Q96RX1
ENST00000368048.7 [Q9UIB8-2]