Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 31 studies | 32% ± 12% | |
mast cell | 19 studies | 30% ± 11% | |
myeloid cell | 13 studies | 28% ± 11% | |
CD8-positive, alpha-beta T cell | 10 studies | 21% ± 4% | |
microglial cell | 10 studies | 32% ± 11% | |
dendritic cell | 8 studies | 23% ± 7% | |
effector memory CD8-positive, alpha-beta T cell | 6 studies | 22% ± 6% | |
T follicular helper cell | 6 studies | 21% ± 3% | |
conventional dendritic cell | 5 studies | 25% ± 5% | |
regulatory T cell | 5 studies | 18% ± 2% | |
CD8-positive, alpha-beta memory T cell | 5 studies | 19% ± 2% | |
T cell | 4 studies | 18% ± 2% | |
monocyte | 4 studies | 25% ± 5% | |
hematopoietic precursor cell | 4 studies | 24% ± 7% | |
megakaryocyte-erythroid progenitor cell | 4 studies | 43% ± 14% | |
alveolar macrophage | 3 studies | 21% ± 3% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 3% | |
classical monocyte | 3 studies | 28% ± 2% | |
exhausted T cell | 3 studies | 35% ± 11% | |
mononuclear phagocyte | 3 studies | 24% ± 4% | |
tissue-resident macrophage | 3 studies | 22% ± 1% | |
leukocyte | 3 studies | 23% ± 3% | |
gamma-delta T cell | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 4 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 1793.74 | 576 / 578 | 86% | 8.82 | 991 / 1155 |
breast | 91% | 593.22 | 416 / 459 | 90% | 9.09 | 1001 / 1118 |
pancreas | 92% | 416.87 | 301 / 328 | 78% | 5.71 | 138 / 178 |
stomach | 89% | 339.22 | 318 / 359 | 68% | 5.91 | 195 / 286 |
esophagus | 86% | 388.19 | 1243 / 1445 | 64% | 3.77 | 118 / 183 |
bladder | 100% | 542.71 | 21 / 21 | 47% | 3.05 | 238 / 504 |
intestine | 93% | 767.44 | 895 / 966 | 52% | 3.61 | 275 / 527 |
brain | 46% | 201.49 | 1217 / 2642 | 88% | 8.81 | 617 / 705 |
thymus | 72% | 416.96 | 468 / 653 | 61% | 3.72 | 367 / 605 |
skin | 60% | 234.22 | 1089 / 1809 | 67% | 6.41 | 317 / 472 |
kidney | 46% | 246.56 | 41 / 89 | 80% | 9.29 | 720 / 901 |
prostate | 86% | 388.16 | 211 / 245 | 39% | 1.68 | 198 / 502 |
uterus | 73% | 233.22 | 124 / 170 | 49% | 2.63 | 225 / 459 |
adrenal gland | 93% | 722.78 | 239 / 258 | 20% | 0.79 | 46 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 32.04 | 29 / 29 |
spleen | 100% | 4210.99 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 1974.15 | 915 / 929 | 0% | 0 | 0 / 0 |
adipose | 98% | 1158.24 | 1185 / 1204 | 0% | 0 | 0 / 0 |
ovary | 31% | 105.31 | 55 / 180 | 65% | 3.93 | 280 / 430 |
liver | 55% | 190.87 | 124 / 226 | 29% | 1.36 | 116 / 406 |
tonsil | 0% | 0 | 0 / 0 | 71% | 6.25 | 32 / 45 |
blood vessel | 70% | 494.25 | 928 / 1335 | 0% | 0 | 0 / 0 |
heart | 50% | 162.45 | 434 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 18% | 0.66 | 14 / 80 |
muscle | 12% | 27.33 | 94 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0043305 | Biological process | negative regulation of mast cell degranulation |
GO_0032715 | Biological process | negative regulation of interleukin-6 production |
GO_0045087 | Biological process | innate immune response |
GO_0043030 | Biological process | regulation of macrophage activation |
GO_0002250 | Biological process | adaptive immune response |
GO_0032701 | Biological process | negative regulation of interleukin-18 production |
GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
GO_0032685 | Biological process | negative regulation of granulocyte macrophage colony-stimulating factor production |
GO_0071639 | Biological process | positive regulation of monocyte chemotactic protein-1 production |
GO_0006914 | Biological process | autophagy |
GO_2001256 | Biological process | regulation of store-operated calcium entry |
GO_0033004 | Biological process | negative regulation of mast cell activation |
GO_0042110 | Biological process | T cell activation |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0006952 | Biological process | defense response |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CD84 |
Protein name | Leucocyte differentiation antigen CD84 SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84) Alternative protein CD84 |
Synonyms | SLAMF5 |
Description | FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 . In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 . . |
Accessions | Q9UIB8 L8E7X8 ENST00000368051.3 [Q9UIB8-5] ENST00000368054.8 [Q9UIB8-3] ENST00000534968.5 [Q9UIB8-7] ENST00000311224.8 [Q9UIB8-1] Q96RX1 ENST00000368048.7 [Q9UIB8-2] |