CD74 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032722Biological processpositive regulation of chemokine production
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0001961Biological processpositive regulation of cytokine-mediated signaling pathway
GO_0002606Biological processpositive regulation of dendritic cell antigen processing and presentation
GO_0045657Biological processpositive regulation of monocyte differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001516Biological processprostaglandin biosynthetic process
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0019882Biological processantigen processing and presentation
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0002906Biological processnegative regulation of mature B cell apoptotic process
GO_0070206Biological processprotein trimerization
GO_0002792Biological processnegative regulation of peptide secretion
GO_0010628Biological processpositive regulation of gene expression
GO_0031394Biological processpositive regulation of prostaglandin biosynthetic process
GO_2000343Biological processpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0035691Biological processmacrophage migration inhibitory factor signaling pathway
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0030336Biological processnegative regulation of cell migration
GO_0045060Biological processnegative thymic T cell selection
GO_0045059Biological processpositive thymic T cell selection
GO_2000448Biological processpositive regulation of macrophage migration inhibitory factor signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0002286Biological processT cell activation involved in immune response
GO_0045581Biological processnegative regulation of T cell differentiation
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0034341Biological processresponse to type II interferon
GO_0033674Biological processpositive regulation of kinase activity
GO_0019883Biological processantigen processing and presentation of endogenous antigen
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0006886Biological processintracellular protein transport
GO_0043030Biological processregulation of macrophage activation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0065003Biological processprotein-containing complex assembly
GO_0045058Biological processT cell selection
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0002830Biological processpositive regulation of type 2 immune response
GO_0005773Cellular componentvacuole
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0009986Cellular componentcell surface
GO_0043202Cellular componentlysosomal lumen
GO_0005634Cellular componentnucleus
GO_0070062Cellular componentextracellular exosome
GO_0009897Cellular componentexternal side of plasma membrane
GO_0035692Cellular componentmacrophage migration inhibitory factor receptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0032991Cellular componentprotein-containing complex
GO_0000139Cellular componentGolgi membrane
GO_0005771Cellular componentmultivesicular body
GO_0005737Cellular componentcytoplasm
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0035693Cellular componentNOS2-CD74 complex
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0042613Cellular componentMHC class II protein complex
GO_0030658Cellular componenttransport vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042658Molecular functionMHC class II protein binding, via antigen binding groove
GO_0035718Molecular functionmacrophage migration inhibitory factor binding
GO_0019955Molecular functioncytokine binding
GO_0050998Molecular functionnitric-oxide synthase binding
GO_0042802Molecular functionidentical protein binding
GO_0004896Molecular functioncytokine receptor activity
GO_0042609Molecular functionCD4 receptor binding
GO_0044183Molecular functionprotein folding chaperone
GO_0001540Molecular functionamyloid-beta binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0042289Molecular functionMHC class II protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD74
Protein nameCD74 molecule
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]
SynonymsDHLAG
DescriptionFUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. .; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 . Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform . .

AccessionsE7EQJ3
ENST00000523208.6
ENST00000009530.13 [P04233-1]
ENST00000377795.7 [P04233-3]
P04233
ENST00000353334.11 [P04233-2]
ENST00000518797.6
ENST00000522246.5
H0YBZ8
H0YBZ2