P2RX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	20 studies	32% ± 16%	Explore
non-classical monocyte	8 studies	30% ± 13%	Explore
plasmacytoid dendritic cell	8 studies	25% ± 10%	Explore
platelet	7 studies	24% ± 8%	Explore
plasma cell	5 studies	22% ± 5%	Explore
hematopoietic precursor cell	4 studies	25% ± 7%	Explore
classical monocyte	3 studies	25% ± 7%	Explore
megakaryocyte	3 studies	55% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 15%	Explore
monocyte	3 studies	24% ± 4%	Explore
hematopoietic stem cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of P2RX1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	5346.57	328 / 328	81%	4.79	145 / 178
prostate	93%	2609.17	229 / 245	88%	5.60	440 / 502
lung	97%	1480.08	563 / 578	79%	2.97	913 / 1155
bladder	95%	14849.48	20 / 21	52%	3.43	263 / 504
intestine	88%	2107.07	852 / 966	58%	1.72	305 / 527
esophagus	76%	1283.49	1104 / 1445	50%	1.96	92 / 183
uterus	78%	1357.59	132 / 170	45%	2.04	206 / 459
stomach	44%	395.96	159 / 359	67%	2.49	191 / 286
spleen	100%	3815.59	241 / 241	0%	0	0 / 0
peripheral blood	92%	5226.25	851 / 929	0%	0	0 / 0
skin	36%	487.11	659 / 1809	39%	1.22	183 / 472
kidney	13%	131.87	12 / 89	59%	1.55	536 / 901
blood vessel	70%	12914.76	933 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	4.12	18 / 29
tonsil	0%	0	0 / 0	60%	1.53	27 / 45
breast	15%	210.85	67 / 459	41%	1.09	455 / 1118
ovary	28%	340.84	50 / 180	21%	0.53	92 / 430
adipose	44%	1176.93	524 / 1204	0%	0	0 / 0
thymus	6%	54.05	37 / 653	31%	1.26	188 / 605
adrenal gland	5%	37.58	12 / 258	23%	0.91	54 / 230
brain	1%	3.66	17 / 2642	18%	0.43	124 / 705
liver	1%	6.66	2 / 226	15%	0.34	62 / 406
heart	14%	106.26	121 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.13	3 / 80
muscle	1%	19.05	11 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007320	Biological process	insemination
GO_0019722	Biological process	calcium-mediated signaling
GO_0033198	Biological process	response to ATP
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0007165	Biological process	signal transduction
GO_0008217	Biological process	regulation of blood pressure
GO_0006811	Biological process	monoatomic ion transport
GO_0035590	Biological process	purinergic nucleotide receptor signaling pathway
GO_0046513	Biological process	ceramide biosynthetic process
GO_0030168	Biological process	platelet activation
GO_0019228	Biological process	neuronal action potential
GO_0099509	Biological process	regulation of presynaptic cytosolic calcium ion concentration
GO_0006915	Biological process	apoptotic process
GO_0003056	Biological process	regulation of vascular associated smooth muscle contraction
GO_1905665	Biological process	positive regulation of calcium ion import across plasma membrane
GO_0002554	Biological process	serotonin secretion by platelet
GO_2000300	Biological process	regulation of synaptic vesicle exocytosis
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098978	Cellular component	glutamatergic synapse
GO_0030667	Cellular component	secretory granule membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0032991	Cellular component	protein-containing complex
GO_0045211	Cellular component	postsynaptic membrane
GO_0044877	Molecular function	protein-containing complex binding
GO_0001614	Molecular function	purinergic nucleotide receptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005261	Molecular function	monoatomic cation channel activity
GO_0099604	Molecular function	ligand-gated calcium channel activity
GO_0043924	Molecular function	suramin binding
GO_0005524	Molecular function	ATP binding
GO_0004931	Molecular function	extracellularly ATP-gated monoatomic cation channel activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	P2RX1
Protein name	Purinergic receptor P2X1 ATP receptor (Purinergic receptor) Purinergic receptor P2X 1 P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)
Synonyms	P2X1
Description	FUNCTION: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). .
Accessions	ENST00000225538.4 P51575 K4JYE8 ENST00000571637.1 I3L3H3 Q6PIW1

P2RX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review