CD276 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050776Biological processregulation of immune response
GO_0050852Biological processT cell receptor signaling pathway
GO_0042110Biological processT cell activation
GO_0001817Biological processregulation of cytokine production
GO_0009897Cellular componentexternal side of plasma membrane
GO_0016020Cellular componentmembrane
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD276
Protein nameCD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
CD276 molecule
SynonymsB7H3
PSEC0249
UNQ309/PRO352
DescriptionFUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. .

AccessionsENST00000318424.9 [Q5ZPR3-2]
ENST00000567189.5
H0YN85
ENST00000318443.10 [Q5ZPR3-1]
H0YL10
ENST00000537340.6
ENST00000560995.5
H0YN29
H3BM68
ENST00000564751.5 [Q5ZPR3-2]
ENST00000561213.5 [Q5ZPR3-4]
ENST00000561260.5
H0YK59
Q5ZPR3
ENST00000563584.5
ENST00000561176.5
H0YLT3
ENST00000560928.5
H0YKQ9
ENST00000558689.5
A0A0C4DGH0
ENST00000561416.5
ENST00000559073.1
H0YK40
ENST00000567582.5
ENST00000560786.6
H0YLT8