IL6ST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0005977Biological processglycogen metabolic process
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0034097Biological processresponse to cytokine
GO_0038165Biological processoncostatin-M-mediated signaling pathway
GO_0048711Biological processpositive regulation of astrocyte differentiation
GO_0038154Biological processinterleukin-11-mediated signaling pathway
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0070120Biological processciliary neurotrophic factor-mediated signaling pathway
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0060576Biological processintestinal epithelial cell development
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0002821Biological processpositive regulation of adaptive immune response
GO_0002675Biological processpositive regulation of acute inflammatory response
GO_1901731Biological processpositive regulation of platelet aggregation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0048861Biological processleukemia inhibitory factor signaling pathway
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0070106Biological processinterleukin-27-mediated signaling pathway
GO_0005896Cellular componentinterleukin-6 receptor complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005900Cellular componentoncostatin-M receptor complex
GO_0070110Cellular componentciliary neurotrophic factor receptor complex
GO_0019970Molecular functioninterleukin-11 binding
GO_0015026Molecular functioncoreceptor activity
GO_0004924Molecular functiononcostatin-M receptor activity
GO_0004897Molecular functionciliary neurotrophic factor receptor activity
GO_0004915Molecular functioninterleukin-6 receptor activity
GO_0004923Molecular functionleukemia inhibitory factor receptor activity
GO_0019955Molecular functioncytokine binding
GO_0042802Molecular functionidentical protein binding
GO_0030296Molecular functionprotein tyrosine kinase activator activity
GO_0045509Molecular functioninterleukin-27 receptor activity
GO_0097110Molecular functionscaffold protein binding
GO_0004921Molecular functioninterleukin-11 receptor activity
GO_0005138Molecular functioninterleukin-6 receptor binding
GO_0004896Molecular functioncytokine receptor activity
GO_0019838Molecular functiongrowth factor binding
GO_0005127Molecular functionciliary neurotrophic factor receptor binding
GO_0019981Molecular functioninterleukin-6 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL6ST
Protein nameIL6ST nirs variant 6 (Interleukin 6 cytokine family signal transducer)
IL6ST nirs variant 2
IL6ST nirs variant 3 (Interleukin 6 cytokine family signal transducer)
Interleukin 6 cytokine family signal transducer
IL6ST isoform 4
IL6ST nirs variant 5
Interleukin 6 signal transducer (Gp130, oncostatin M receptor)
IL6ST nirs variant 1 (Interleukin 6 cytokine family signal transducer)
IL6ST isoform 3 (Interleukin 6 cytokine family signal transducer)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Synonyms
DescriptionFUNCTION: Signal-transducing molecule . The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 . In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). .; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response . Also blocks IL11 cluster signaling through IL11R . .

AccessionsENST00000577363.2
Q5FC07
ENST00000698643.1
Q5FC02
Q17RA0
A0A8V8TM11
P40189
ENST00000698638.1
A0A8V8TNI8
ENST00000381298.7 [P40189-1]
D6RH03
A0A0A0N0L2
ENST00000381286.7
ENST00000698648.1
Q5FC03
A0A8V8TMJ4
ENST00000503773.6
ENST00000698647.1
A0A8V8TNI4
Q5FC06
ENST00000522633.2 [P40189-2]
ENST00000698641.1
A0A0A0N0L5
ENST00000502326.7 [P40189-1]
ENST00000698644.1
ENST00000651614.1
ENST00000698639.1
ENST00000381293.6
ENST00000698640.1
ENST00000698642.1
ENST00000381294.8 [P40189-3]
ENST00000698645.1 [P40189-1]
Q5FC05
ENST00000698646.1
A0A8V8TNU5
A0A8V8TMJ9
A0A494BZU0