CTSB report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
macrophage	52 studies	79% ± 19%	Explore
fibroblast	37 studies	33% ± 15%	Explore
endothelial cell	34 studies	31% ± 12%	Explore
classical monocyte	29 studies	69% ± 16%	Explore
conventional dendritic cell	28 studies	56% ± 17%	Explore
monocyte	26 studies	63% ± 19%	Explore
dendritic cell	25 studies	49% ± 20%	Explore
non-classical monocyte	25 studies	66% ± 15%	Explore
plasmacytoid dendritic cell	25 studies	72% ± 19%	Explore
smooth muscle cell	23 studies	27% ± 11%	Explore
basal cell	21 studies	50% ± 19%	Explore
epithelial cell	20 studies	45% ± 21%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 8%	Explore
mast cell	16 studies	31% ± 8%	Explore
microglial cell	16 studies	56% ± 22%	Explore
pericyte	16 studies	30% ± 16%	Explore
myeloid cell	16 studies	76% ± 16%	Explore
regulatory T cell	16 studies	25% ± 8%	Explore
connective tissue cell	15 studies	37% ± 19%	Explore
ciliated cell	14 studies	40% ± 17%	Explore
endothelial cell of lymphatic vessel	13 studies	27% ± 11%	Explore
myofibroblast cell	13 studies	35% ± 11%	Explore
T cell	11 studies	22% ± 4%	Explore
erythrocyte	11 studies	30% ± 15%	Explore
secretory cell	11 studies	51% ± 15%	Explore
capillary endothelial cell	11 studies	25% ± 6%	Explore
endothelial cell of artery	10 studies	25% ± 7%	Explore
endothelial cell of vascular tree	10 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 8%	Explore
neutrophil	9 studies	40% ± 17%	Explore
alveolar macrophage	8 studies	82% ± 15%	Explore
mononuclear phagocyte	8 studies	64% ± 21%	Explore
astrocyte	8 studies	28% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
leukocyte	8 studies	50% ± 13%	Explore
vein endothelial cell	8 studies	23% ± 4%	Explore
B cell	7 studies	21% ± 8%	Explore
type II pneumocyte	7 studies	23% ± 5%	Explore
club cell	7 studies	55% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 11%	Explore
abnormal cell	7 studies	37% ± 10%	Explore
enterocyte	7 studies	28% ± 11%	Explore
goblet cell	7 studies	32% ± 14%	Explore
memory B cell	7 studies	17% ± 2%	Explore
T follicular helper cell	7 studies	27% ± 10%	Explore
respiratory goblet cell	6 studies	71% ± 12%	Explore
glutamatergic neuron	6 studies	30% ± 17%	Explore
plasma cell	6 studies	25% ± 10%	Explore
CD8-positive, alpha-beta T cell	6 studies	22% ± 7%	Explore
intermediate monocyte	6 studies	77% ± 19%	Explore
type I pneumocyte	5 studies	24% ± 6%	Explore
natural killer cell	5 studies	20% ± 3%	Explore
transit amplifying cell	5 studies	20% ± 3%	Explore
mucus secreting cell	5 studies	30% ± 17%	Explore
inflammatory macrophage	5 studies	64% ± 24%	Explore
melanocyte	5 studies	42% ± 21%	Explore
deuterosomal cell	4 studies	34% ± 12%	Explore
duct epithelial cell	4 studies	67% ± 11%	Explore
ionocyte	4 studies	31% ± 6%	Explore
squamous epithelial cell	4 studies	63% ± 18%	Explore
pancreatic A cell	4 studies	57% ± 22%	Explore
exhausted T cell	4 studies	26% ± 6%	Explore
progenitor cell	4 studies	25% ± 8%	Explore
GABAergic neuron	4 studies	32% ± 15%	Explore
amacrine cell	4 studies	25% ± 9%	Explore
retinal ganglion cell	4 studies	75% ± 23%	Explore
kidney loop of Henle epithelial cell	4 studies	25% ± 6%	Explore
lymphocyte	4 studies	24% ± 8%	Explore
adventitial cell	4 studies	33% ± 6%	Explore
erythroblast	4 studies	32% ± 17%	Explore
endothelial cell of sinusoid	4 studies	26% ± 6%	Explore
mesothelial cell	4 studies	27% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	36% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 8%	Explore
hepatocyte	4 studies	52% ± 27%	Explore
luminal cell of prostate epithelium	4 studies	30% ± 10%	Explore
monocyte-derived dendritic cell	4 studies	56% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 7%	Explore
neuron	4 studies	30% ± 11%	Explore
brush cell	4 studies	29% ± 9%	Explore
enteroendocrine cell	4 studies	31% ± 8%	Explore
hematopoietic stem cell	4 studies	17% ± 2%	Explore
hillock cell	3 studies	64% ± 22%	Explore
plasmablast	3 studies	37% ± 4%	Explore
pancreatic D cell	3 studies	49% ± 25%	Explore
type B pancreatic cell	3 studies	59% ± 18%	Explore
hematopoietic precursor cell	3 studies	32% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 10%	Explore
renal alpha-intercalated cell	3 studies	29% ± 9%	Explore
intestinal crypt stem cell	3 studies	22% ± 5%	Explore
naive B cell	3 studies	18% ± 2%	Explore
extravillous trophoblast	3 studies	62% ± 5%	Explore
placental villous trophoblast	3 studies	66% ± 5%	Explore
serous secreting cell	3 studies	47% ± 17%	Explore
tissue-resident macrophage	3 studies	90% ± 7%	Explore
Mueller cell	3 studies	28% ± 3%	Explore
oligodendrocyte	3 studies	19% ± 2%	Explore
granulocyte	3 studies	29% ± 11%	Explore
pancreatic ductal cell	3 studies	65% ± 24%	Explore
T-helper 17 cell	3 studies	21% ± 3%	Explore
T-helper 1 cell	3 studies	26% ± 11%	Explore
interneuron	3 studies	40% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	41% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 3%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	19 studies	40% ± 17%	Explore
peripheral blood	19 studies	28% ± 8%	Explore
intestine	11 studies	26% ± 10%	Explore
brain	10 studies	36% ± 22%	Explore
kidney	9 studies	33% ± 9%	Explore
liver	9 studies	34% ± 18%	Explore
uterus	6 studies	42% ± 19%	Explore
eye	5 studies	25% ± 4%	Explore
placenta	5 studies	47% ± 22%	Explore
prostate	5 studies	38% ± 12%	Explore
pancreas	4 studies	52% ± 24%	Explore
bone marrow	4 studies	21% ± 3%	Explore
skin	4 studies	18% ± 2%	Explore
breast	4 studies	24% ± 5%	Explore
adipose	3 studies	31% ± 6%	Explore
esophagus	3 studies	48% ± 18%	Explore
heart	3 studies	22% ± 2%	Explore
lymph node	3 studies	43% ± 35%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	38108.75	1444 / 1445	100%	471.59	183 / 183
lung	100%	55834.15	577 / 578	99%	525.37	1144 / 1155
skin	99%	56608.79	1799 / 1809	99%	863.66	468 / 472
ovary	100%	21506.92	180 / 180	98%	357.66	421 / 430
breast	100%	31674.30	458 / 459	98%	340.78	1096 / 1118
uterus	100%	40229.46	170 / 170	98%	454.75	448 / 459
intestine	100%	35204.08	966 / 966	96%	299.76	507 / 527
kidney	100%	47405.17	89 / 89	95%	395.98	858 / 901
thymus	100%	164664.28	653 / 653	95%	2954.35	572 / 605
liver	100%	38724.64	225 / 226	91%	270.56	371 / 406
brain	93%	18392.30	2456 / 2642	97%	288.11	685 / 705
bladder	100%	34809.33	21 / 21	89%	337.64	450 / 504
stomach	88%	19237.04	316 / 359	97%	348.80	277 / 286
prostate	100%	37441.74	245 / 245	79%	147.40	397 / 502
adrenal gland	100%	38034.22	258 / 258	60%	124.94	139 / 230
pancreas	63%	8193.09	205 / 328	97%	396.34	172 / 178
adipose	100%	51929.42	1204 / 1204	0%	0	0 / 0
spleen	100%	64855.11	241 / 241	0%	0	0 / 0
blood vessel	99%	32461.57	1315 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	704.54	28 / 29
eye	0%	0	0 / 0	96%	297.86	77 / 80
tonsil	0%	0	0 / 0	96%	447.73	43 / 45
heart	93%	34432.72	803 / 861	0%	0	0 / 0
muscle	89%	16919.06	714 / 803	0%	0	0 / 0
peripheral blood	85%	27304.19	790 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1