ASGR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044419Biological processbiological process involved in interspecies interaction between organisms
GO_0006898Biological processreceptor-mediated endocytosis
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0042806Molecular functionfucose binding
GO_0005537Molecular functionD-mannose binding
GO_0004873Molecular functionasialoglycoprotein receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameASGR1
Protein nameAsialoglycoprotein receptor 1
ASGR1 protein (Asialoglycoprotein receptor 1)
Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1)
SynonymshCG_1985284
CLEC4H1
DescriptionFUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

AccessionsI3L1F8
ENST00000269299.8 [P07306-1]
ENST00000570576.1
ENST00000574388.5 [P07306-2]
ENST00000380920.8
J3QSZ2
I3L129
Q6FGQ5
ENST00000573083.1
I3L2S9
ENST00000619926.4 [P07306-2]
K7EPS5
ENST00000574330.5
ENST00000572879.5
P07306