CD244 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD244 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0002250Biological processadaptive immune response
GO_0032729Biological processpositive regulation of type II interferon production
GO_0060732Biological processpositive regulation of inositol phosphate biosynthetic process
GO_0071663Biological processpositive regulation of granzyme B production
GO_0002323Biological processnatural killer cell activation involved in immune response
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0045087Biological processinnate immune response
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0042288Molecular functionMHC class I protein binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD244
Protein nameNatural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Synonyms2B4
DescriptionFUNCTION: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor . Activating function implicates association with SH2D1A and FYN . Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 . Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis . Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 . At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells . Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). .

AccessionsENST00000492063.5 [Q9BZW8-3]
ENST00000322302.7 [Q9BZW8-4]
ENST00000368034.9 [Q9BZW8-2]
ENST00000368033.7 [Q9BZW8-1]
Q9BZW8