ITGA4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	35% ± 10%	Explore
CD8-positive, alpha-beta T cell	33 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	28 studies	28% ± 9%	Explore
T cell	27 studies	31% ± 14%	Explore
B cell	26 studies	30% ± 8%	Explore
non-classical monocyte	23 studies	46% ± 17%	Explore
regulatory T cell	22 studies	29% ± 7%	Explore
naive B cell	18 studies	29% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	41% ± 12%	Explore
conventional dendritic cell	17 studies	35% ± 18%	Explore
gamma-delta T cell	17 studies	40% ± 14%	Explore
mature NK T cell	17 studies	33% ± 8%	Explore
memory B cell	17 studies	27% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	25% ± 7%	Explore
plasmacytoid dendritic cell	15 studies	28% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 10%	Explore
classical monocyte	15 studies	27% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	32% ± 7%	Explore
dendritic cell	13 studies	41% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	42% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	40% ± 13%	Explore
mucosal invariant T cell	13 studies	32% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	31% ± 10%	Explore
mast cell	10 studies	34% ± 21%	Explore
monocyte	10 studies	27% ± 9%	Explore
plasma cell	9 studies	35% ± 15%	Explore
plasmablast	9 studies	51% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	38% ± 14%	Explore
macrophage	8 studies	23% ± 6%	Explore
hematopoietic stem cell	7 studies	50% ± 8%	Explore
precursor B cell	7 studies	36% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	38% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	41% ± 13%	Explore
leukocyte	6 studies	39% ± 16%	Explore
immature B cell	6 studies	38% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	38% ± 8%	Explore
erythrocyte	6 studies	30% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	37% ± 9%	Explore
hematopoietic precursor cell	5 studies	61% ± 15%	Explore
exhausted T cell	5 studies	45% ± 11%	Explore
lymphocyte	5 studies	44% ± 18%	Explore
pro-B cell	5 studies	42% ± 11%	Explore
pericyte	5 studies	26% ± 11%	Explore
myeloid cell	5 studies	26% ± 6%	Explore
innate lymphoid cell	5 studies	39% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	44% ± 12%	Explore
mononuclear phagocyte	4 studies	25% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	55% ± 23%	Explore
double negative thymocyte	4 studies	49% ± 15%	Explore
CD4-positive helper T cell	3 studies	32% ± 8%	Explore
common myeloid progenitor	3 studies	38% ± 25%	Explore
erythroblast	3 studies	53% ± 23%	Explore
granulocyte monocyte progenitor cell	3 studies	35% ± 18%	Explore
T follicular helper cell	3 studies	26% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 13%	Explore
T-helper 17 cell	3 studies	25% ± 6%	Explore
T-helper 1 cell	3 studies	34% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 2%	Explore
IgA plasma cell	3 studies	27% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	32% ± 14%	Explore
bone marrow	4 studies	33% ± 14%	Explore
liver	4 studies	26% ± 12%	Explore
lymph node	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1380.90	577 / 578	88%	7.08	1015 / 1155
breast	89%	332.17	407 / 459	84%	6.31	941 / 1118
intestine	97%	765.96	936 / 966	72%	4.11	378 / 527
stomach	87%	250.99	312 / 359	79%	5.69	226 / 286
esophagus	65%	149.79	939 / 1445	76%	5.39	139 / 183
thymus	81%	321.75	529 / 653	50%	6.67	305 / 605
kidney	60%	223.96	53 / 89	71%	8.64	642 / 901
bladder	76%	338.43	16 / 21	53%	3.26	269 / 504
uterus	76%	231.22	130 / 170	53%	2.69	242 / 459
skin	56%	1410.72	1009 / 1809	70%	10.47	332 / 472
prostate	77%	223.78	188 / 245	41%	1.82	204 / 502
spleen	100%	3330.81	241 / 241	0%	0	0 / 0
peripheral blood	98%	3808.22	910 / 929	0%	0	0 / 0
adipose	95%	418.24	1147 / 1204	0%	0	0 / 0
pancreas	19%	39.57	61 / 328	75%	4.84	133 / 178
lymph node	0%	0	0 / 0	83%	12.37	24 / 29
liver	57%	119.79	129 / 226	22%	0.96	90 / 406
adrenal gland	53%	107.20	136 / 258	26%	1.08	59 / 230
ovary	31%	66.46	55 / 180	44%	1.74	188 / 430
blood vessel	73%	276.92	968 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	4.94	30 / 45
brain	28%	84.28	734 / 2642	36%	1.95	252 / 705
heart	24%	50.19	206 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.43	9 / 80
muscle	2%	3.49	17 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0090074	Biological process	negative regulation of protein homodimerization activity
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0033631	Biological process	cell-cell adhesion mediated by integrin
GO_0007160	Biological process	cell-matrix adhesion
GO_0035987	Biological process	endodermal cell differentiation
GO_0060385	Biological process	axonogenesis involved in innervation
GO_0002387	Biological process	immune response in gut-associated lymphoid tissue
GO_1905564	Biological process	positive regulation of vascular endothelial cell proliferation
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0050904	Biological process	diapedesis
GO_1990771	Biological process	clathrin-dependent extracellular exosome endocytosis
GO_0043113	Biological process	receptor clustering
GO_1903238	Biological process	positive regulation of leukocyte tethering or rolling
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0050901	Biological process	leukocyte tethering or rolling
GO_0045906	Biological process	negative regulation of vasoconstriction
GO_1990138	Biological process	neuron projection extension
GO_0003366	Biological process	cell-matrix adhesion involved in ameboidal cell migration
GO_2000406	Biological process	positive regulation of T cell migration
GO_0098609	Biological process	cell-cell adhesion
GO_1904646	Biological process	cellular response to amyloid-beta
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0030183	Biological process	B cell differentiation
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0008305	Cellular component	integrin complex
GO_0070062	Cellular component	extracellular exosome
GO_0043025	Cellular component	neuronal cell body
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0030426	Cellular component	growth cone
GO_0034669	Cellular component	integrin alpha4-beta7 complex
GO_0034668	Cellular component	integrin alpha4-beta1 complex
GO_0015026	Molecular function	coreceptor activity
GO_0019960	Molecular function	C-X3-C chemokine binding
GO_0001968	Molecular function	fibronectin binding
GO_0005178	Molecular function	integrin binding
GO_1990405	Molecular function	protein antigen binding
GO_0046872	Molecular function	metal ion binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGA4
Protein name	Integrin a4-subunit Integrin a4 subunit Alpha-4 integrin Integrin subunit alpha 4 ITGA4 protein Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Synonyms	CD49D
Description	FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction . .
Accessions	A0A023IPH2 P13612 E7EP60 ENST00000397033.7 [P13612-1] A0A023IP86 ENST00000233573.6 A0A023IPI3 Q68EM9 A0A023IP90 A0A023IPA9 A0A023IPH8 A0A023IP88 A0A023IQJ5 A0A023IQA6 Q6PJE7 A0A023IPA8 Q13682 A0A023IQK0 A0A023IQJ3 ENST00000339307.8 [P13612-2]

ITGA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review